Renal function markers and thyroid hormone status in undialyzed chronic kidney disease

Objective: The study was undertaken to quantify thyroid hormones in undialyzed chronic kidney disease patients’ verses controls and to study the correlation between renal function markers and thyroid hormones. Background: Chronic kidney disease (CKD) is associated with a higher prevalence of primary hypothyroidism (HT), but at the same studies on thyroid hormone status in uremic patients has reported conflicting results. Methods: Thyroid hormones and renal function parameters like serum urea, creatinine, creatinine clearance, total protein and albumin were estimated and correlations between thyroid hormones and renal function parameters were studied in 60 undialyzed chronic kidney disease patients’ verses 100 healthy controls. Results: We found both T3 and T4 were significantly reduced (p<0.0001 for T3 and 0.007 for T4) whereas TSH remains to be unchanged in patient group compared to controls. We also observed that urea and creatinine were negatively correlated whereas creatinine clearance was positively correlated with both T3 and T4 that has high statistical (two-tailed) significance at 0.01 level. But urea alone is negatively correlated with TSH that has statistical (two-tailed) significance at 0.05 level. Conclusion: From our data, we speculate that renal insufficiency may lead to thyroid hormone disturbances

Atherogenic risk in premature canities among college students India

Introduction: &nbsp;Appearance of gray hair before the age of 25 years in Asian population considered as premature canities. The degree of hair graying is a risk factor for coronary artery disease. Studies says that visible ageing sign reflects the poor cardiovascular health status irrespective of the chronological ageing. However datas on the role of premature canities is not well established and datas were sparse. Hence the aim of the present study is (i) to evaluate the atherogenic risk in premature canities and (ii) to understand the inter relationship of premature canities&nbsp; with history of diabetes and hypertension Materials and methods:&nbsp; This cross-sectional study was conducted from June 2021 to October 2021 among the college students studying at ACS Medical College &amp; Hospital, Chennai, India. Subjects with vitiligo, premature graying syndrome, Autoimmune thyroid disease or under treatment for any clinical conditions were excluded from this study. The Inclusion criteria were healthy volunteers of aged &lt; 25 years. The study was approved by the institutional ethics committee. After obtaining informed consent demographic parameters were collected in preformed proforma. Fasting blood samples were collected in plain tubes and analyzed for lipid profile, total protein, albumin, thyroid profile. Atherogenic Index of plasma (AIP) calculated.&nbsp