271 research outputs found
Health service outpatient experience questionnarie: factor validity and reliability of a patient- centered outcome measure for outpatient settings in Italy
3PURPOSE:
The patient-centered approach to health care does not seem to be sufficiently developed in the Italian context, and is still characterized by the biomedical model. In addition, there is a lack of validated outcome measures to assess outpatient experience as an aspect common to a variety of settings. The current study aimed to evaluate the factorial validity, reliability, and invariance across sex of the Health Services OutPatient Experience (HSOPE) questionnaire, a short ten-item measure of patient-centeredness for Italian adult outpatients. The rationale for unidimensionality of the measure was that it could cover global patient experience as a process common to patients with a variety of diseases and irrespective of the phase of treatment course.
PATIENTS AND METHODS:
The HSOPE was compiled by 1,532 adult outpatients (51% females, mean age 59.22 years, standard deviation 16.26) receiving care in ten facilities at the Santa Maria alle Scotte University Hospital of Siena, Italy. The sample represented all the age cohorts. Twelve percent were young adults, 57% were adults, and 32% were older adults. Exploratory and confirmatory factor analyses were conducted to evaluate factor structure. Reliability was evaluated as internal consistency using Cronbach's α. Factor invariance was assessed through multigroup analyses.
RESULTS:
Both exploratory and confirmatory analyses suggested a clearly defined unidimensional structure of the measure, with all the ten items having salient loadings on a single factor. Internal consistency was excellent (α=0.95). Indices of model fit supported a single-factor structure for both male and female outpatient groups. Young adult outpatients had significantly lower scores on perceived patient-centeredness relative to older adults. No significant difference emerged on patient-centeredness between male and female outpatients.
CONCLUSION:
The HSOPE questionnaire seemed to be a tool with high acceptability and excellent psychometric properties to measure patient-centeredness as a unidimensional construct. Limitations and implications for future research are discussed.openopenColuccia, Anna; Ferretti, Fabio; Pozza, AndreaColuccia, Anna; Ferretti, Fabio; Pozza, Andre
Borderline, avoidant, sadistic personality traits and emotion dysregulation predict different pathological skin picking subtypes in a community sample
Smoke, alcohol and drug addiction and male fertility
In recent decades, the decline in human fertility has become increasingly more worrying: while therapeutic interventions might help, they are vexing for the couple and often burdened with high failure rates and costs. Prevention is the most successful approach to fertility disorders in males and females alike. We performed a literature review on three of the most common unhealthy habits - tobacco, alcohol and drug addiction - and their reported effects on male fertility. Tobacco smoking is remarkably common in most first-world countries; despite a progressive decline in the US, recent reports suggest a prevalence of more than 30% in subjects of reproductive age - a disturbing perspective, given the well-known ill-effects on reproductive and sexual function as well as general health. Alcohol consumption is often considered socially acceptable, but its negative effects on gonadal function have been consistently reported in the last 30 years. Several studies have reported a variety of negative effects on male fertility following drug abuse - a worrying phenomenon, as illicit drug consumption is on the rise, most notably in younger subjects. While evidence in these regards is still far from solid, mostly as a result of several confounding factors, it is safe to assume that cessation of tobacco smoking, alcohol consumption and recreational drug addiction might represent the best course of action for any couple trying to achieve pregnancy
Depression and Anxiety in Pathways of Medically Assisted Reproduction: The Role of Infertility Stress Dimensions
Sexual masochism disorder with asphyxiophilia: a deadly yet underrecognized disease
DSM-5 distinguishes between paraphilias and paraphilic disorders. Paraphilias are defined as atypical, yet not necessarily disordered, sexual practices. Paraphilic disorders are instead diseases, which include distress, impairment in functioning, or entail risk of harm one's self or others. Hence, DSM-5 new approach to paraphilias demedicalizes and destigmatizes unusual sexual behaviors, provided they are not distressing or detrimental to self or others. Asphyxiophilia, a dangerous and potentially deadly form of sexual masochism involving sexual arousal by oxygen deprivation, are clearly described as disorders. Although autoerotic asphyxia has been associated with estimated mortality rates ranging from 250 to 1000 deaths per year in the United States, in Italy, knowledge on this condition is very poor. Episodes of death caused by autoerotic asphyxia seem to be underestimated because it often can be confounded with suicide cases, particularly in the Italian context where family members of the victim often try to disguise autoerotic behaviors of the victims. The current paper provides a review on sexual masochism disorder with asphyxiophilia and discusses one specific case as an example to examine those conditions that may or may not influence the likelihood that death from autoerotic asphyxia be erroneously reported as suicide or accidental injury
The role of disgust propensity and sensitivity on sexual excitation and inhibition in Obsessive-Compulsive Disorder
Brazilian truckers’ strike and particulate matter (PM10) concentration: Temporal trend and time series models
As altas emissões de material particulado (MP) do tráfego de veĂculos impactam a qualidade do ar em áreas urbanas. Em 2018, uma greve de caminhoneiros interrompeu alguns serviços no Brasil, levando Ă falta de combustĂvel em várias cidades, o que reduziu significativamente o fluxo de veĂculos. Este estudo avaliou a qualidade do ar durante essa greve, em duas cidades (Limeira e Campinas) no Sudeste do Brasil. A concentração de MP10 foi analisada nos perĂodos antes da greve (BTS — 1Âş a 22 de maio 2018), durante a greve (DTS — 23 a 30 de maio de 2018) e depois dela (ATS — 31 de maio de 2018 a 30 de junho de 2018), usando o mĂ©todo Theil-Sen e o modelo ARIMAX. Durante a greve ocorreu redução na concentração mĂ©dia diária de MP10 nas duas cidades. Considerando-se o horário de pico diário do fluxo veicular (18h), a concentração de MP10 foi 20% maior no perĂodo BTS do que no DTS, para ambas as cidades. Em comparação, o perĂodo ATS apresentou concentrações de 17% (Limeira) e 7% (Campinas) maiores, quando comparado com o DTS. As variações foram estatisticamente significativas com base nos modelos de sĂ©ries temporais, e foram avaliadas as influĂŞncias da velocidade do vento, da chuva no dia da amostragem e na vĂ©spera da amostragem e nos fins de semana. TambĂ©m foi possĂvel verificar a contribuição da greve na concentração de MP10 nas duas cidades. Em Limeira, o tráfego de caminhões teve maior influĂŞncia na concentração de MP10, enquanto em Campinas essa contribuição foi similar entre caminhões e veĂculos leves. Com base na variação da concentração de MP10, observou-se a influĂŞncia de mudanças na dinâmica de emissĂŁo veicular, que Ă© uma das principais fontes emissoras nas regiões analisadas. Os resultados mostram que a restrição do tráfego veicular teve impacto imediato na melhoria da qualidade do ar e, entĂŁo, sĂŁo sugeridos investimentos pĂşblicos em outros tipos de transporte e polĂticas de controle de tráfego.High particulate matter (PM) emissions from vehicular traffic impact air quality in urban areas. In 2018, a truckers’ strike interrupted some of the services in Brazil, leading to a fuel outage in several cities that significantly reduced the flow of vehicles. This study evaluated air quality during the strike in two cities (Limeira and Campinas) in Southeastern Brazil. PM10 concentration was analyzed in the periods before (BTS — 05/01/2018 to 05/22/2018), during (DTS — 05/23/2018 to 05/30/2018), and after (ATS — 05/31/2018 to 06/30/2018) the strike using the Theil-Sen method and the Autoregressive Integrated Moving Average model with Exogenous Variables (ARIMAX). A reduction in the PM daily mean concentration in both cities occurred during the strike. Considering the daily peak time of vehicular flow (6:00 p.m.), the PM10 concentration was 20% higher in the BTS period compared to the DTS period for both cities. In comparison, the ATS period showed concentrations 17% (Limeira) and 7% (Campinas) higher when compared with the DTS period. The variations were statistically significant based on the time series models, and the influences of wind speed, rainfall on the sampling day and the day before sampling, and weekends were also evaluated. It was also possible to verify the contribution of the truckers’ strike to the PM10 concentration in the two cities evaluated. In Limeira, truck traffic had a greater influence on the concentration of PM10, while in Campinas, the contribution of trucks was like that of light vehicles. Based on the variation of the PM10 concentration, the influence of changes in vehicle emission dynamics, one of the main sources of emission in the regions studied, was observed. The results indicate that restricting vehicular traffic had an immediate impact on improving air quality. Therefore, public investment in other types of transport and traffic control policies are suggested
A prospective study on contrast-enhanced magnetic resonance imaging of testicular lesions: distinctive features of Leydig cell tumours
OBJECTIVES:
Up to 20 % of incidentally found testicular lesions are benign Leydig cell tumours (LCTs). This study evaluates the role of contrast-enhanced magnetic resonance imaging (MRI) in the identification of LCTs in a large prospective cohort study.
MATERIALS AND METHODS:
We enrolled 44 consecutive patients with at least one solid non-palpable testicular lesion who underwent scrotal MRI. Margins of the lesions, signal intensity and pattern of wash-in and wash-out were analysed by two radiologists. The frequency distribution of malignant and benign MRI features in the different groups was compared by using the chi-squared or Fisher's exact test. Sensitivity, specificity, positive and negative predictive value, and diagnostic accuracy were calculated.
RESULTS:
The sensitivity of scrotal MRI to diagnose LCTs was 89.47 % with 95.65 % specificity; sensitivity for malignant lesions was 95.65 % with 80.95 % specificity. A markedly hypointense signal on T2-WI, rapid and marked wash-in followed by a prolonged washout were distinctive features significantly associated with LCTs. Malignant lesions were significantly associated with blurred margins, weak hypointense signal on T2-WI ,and weak and progressive wash-in. The overall diagnostic accuracy was 93 %.
CONCLUSIONS:
LCTs have distinctive contrast-enhanced MRI features that allow the differential diagnosis of incidental testicular lesions.
KEY POINTS:
• MRI is able to characterize testicular lesions suggesting a specific diagnosis. • Rapid and marked wash-in is a common feature of Leydig cell tumours. • Markedly hypointense T2-WI signal is significantly correlated with benign lesions. • Blurred margins and weak hypointense T2-WI signal are correlated with malignant tumours. • Weak and progressive wash-in features are present in 85 % of seminomatous lesions
The impacts of replacing air bubbles with microspheres for the clarification of algae from low cell-density culture
Dissolved Air Flotation (DAF) is a well-known coagulation–flotation system applied at large scale for microalgae harvesting. Compared to conventional harvesting technologies DAF allows high cell recovery at lower energy demand. By replacing microbubbles with microspheres, the innovative Ballasted Dissolved Air Flotation (BDAF) technique has been reported to achieve the same algae cell removal efficiency, while saving up to 80% of the energy required for the conventional DAF unit. Using three different algae cultures (Scenedesmus obliquus, Chlorella vulgaris and Arthrospira maxima), the present work investigated the practical, economic and environmental advantages of the BDAF system compared to the DAF system. 99% cells separation was achieved with both systems, nevertheless, the BDAF technology allowed up to 95% coagulant reduction depending on the algae species and the pH conditions adopted. In terms of floc structure and strength, the inclusion of microspheres in the algae floc generated a looser aggregate, showing a more compact structure within single cell alga, than large and filamentous cells. Overall, BDAF appeared to be a more reliable and sustainable harvesting system than DAF, as it allowed equal cells recovery reducing energy inputs, coagulant demand and carbon emissions
Clinical presentation, management and follow-up of 83 patients with Leydig cell tumors of the testis: a prospective case-cohort study
LCTs are more frequent than generally believed, are associated with male infertility, cryptorchidism and gynecomastia, and should be treated conservatively (in compliant patients) with active surveillance, which appears to be a safe alternative to surgical enucleation. WHAT IS KNOWN ALREADY Increasing referrals for testicular imaging have led to an increase in findings of LCTs. The features and natural history of these tumors remain largely unknown, as the available studies are small and heterogeneous. LCTs were previously treated aggressively and follow-up data are lacking. STUDY DESIGN, SIZE, DURATION A case-cohort study of consecutive patients diagnosed with LCTs over a 10-year period was prospectively enrolled from 2009 to 2018 and compared to matched cohorts of patients with seminomas or no testicular lesions screened in the same timeframe. PARTICIPANTS/MATERIALS, SETTING, METHODS Of the 9949 inpatients and outpatients referred for scrotal ultrasound, a total of 83 men with LCTs were included. Enrolled subjects underwent medical history and clinical examination and were asked to undergo routine blood tests, hormone investigations (FSH, LH, total testosterone, estradiol, inhibin B, sex hormone-binding globulin (SHBG), prolactin), and semen analysis. Patients who consented also underwent contrast-enhanced ultrasound, elastography, gadolinium-enhanced scrotal magnetic resonance imaging, and hCG stimulation test (5000 IU i.m.) with serum total testosterone and estradiol measured at 0, 24, 48, and 72 hours. MAIN RESULTS AND THE ROLE OF CHANCE In total, 83 patients diagnosed with LCTs were compared against 90 patients diagnosed with seminoma and 2683 patients without testicular lesions (NoL). LCTs were diagnosed by enucleation (48.2%), orchiectomy (13.3%), or clinical surveillance (38.5%). Testicular volume, sperm concentration, and morphology were lower (P = 0.001, P = 0.001, and P < 0.001, respectively) in patients with LCTs than in the NoL group. FSH, LH, and SHBG were higher and the testosterone/LH ratio was lower in LCTs than in the NoL group (P < 0.001). The LCT group showed higher SHBG (P = 0.018), lower sperm concentration (P = 0.029), and lower motility (P = 0.049) than the seminoma group. Risk factors for LCTs were cryptorchidism (χ2 = 28.27, P < 0.001), gynecomastia (χ2 = 54.22, P < 0.001), and low testicular volume (χ2 = 11.13, P = 0.001). Five cases were recurrences or bilateral lesions; none developed metastases during follow-up (median, 66 months). LIMITATIONS, REASONS FOR CAUTION This study has some limitations. First, hCG and second-line diagnostic investigations were not available for all tumor patients. Second, ours is a referral center for infertility, thus a selection bias may have altered the baseline features of the LCT population. However, given that the comparison cohorts were also from the same center and had been managed with a similar protocol, we do not expect a significant effect. WIDER IMPLICATIONS OF THE FINDINGS LCTs are strongly associated with male infertility, cryptorchidism, and gynecomastia, supporting the hypothesis that testicular dysgenesis syndrome plays a role in their development. Patients with LCTs are at a greater risk of endocrine and spermatogenesis abnormalities even when the tumor is resected, and thus require long-term follow-up and prompt efforts to preserve fertility after diagnosis. LCTs have a good oncological prognosis when recognized early, as tissue-sparing enucleation is curative and should replace orchiectomy. Conservative surgery and, in compliant patients, active surveillance through clinical and radiological follow-up are safe options, but require monitoring of testicular failure and recurrence
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