DNA repair gene polymorphisms and genetic predisposition to cutaneous melanoma

The incidence of cutaneous melanoma is rising rapidly in a number of countries. The key environmental risk factor is exposure to the ultraviolet (UV) component in sunlight. The nucleotide excision repair (NER) pathway deals with the main forms of UV-induced DNA damage. We have investigated the hypothesis that polymorphisms in NER genes constitute genetic susceptibility factors for melanoma. However, not all melanomas arise on sun-exposed sites and so we investigated the hypothesis that genes involved in other pathways for the repair of oxidative DNA damage may also be involved in susceptibility to melanoma. Scotland, with its high incidence of melanoma and stable homogeneous population, was ideal for this case-control study, involving 596 Scottish melanoma patients and 441 population-based controls. Significant associations were found for the NER genes ERCC1 and XPF, with the strongest associations for melanoma cases aged 50 and under [ERCC1 odds ratio (OR) 1.59, P = 0.008; XPF OR 1.69, P = 0.003]. Although an XPD haplotype was associated with melanoma, it did not contain the variant 751 Gln allele, which has been associated with melanoma in some previous studies. No associations were found for the base excision repair and DNA damage response genes investigated. An association was also found for a polymorphism in the promoter of the vitamin D receptor gene, VDR (OR 1.88, P = 0.005). The products of the two NER genes, ERCC1 and XPF, where associations with melanoma were found, act together in a rate-limiting step in the repair pathwa

The development of a new multi-faceted model of social wellbeing: does income level make a difference?

Recent research has suggested that income, while playing a part in quality of life, may have only a limited impact on a multi-faceted concept such as social wellbeing. Using data from an Australian household survey (Living in Queensland Survey), a composite Wellbeing Index was created that covered objective circumstances, with known associations to wellbeing, evaluated from the individual’s subjective viewpoint. The importance attributed to each dimension added to the robustness of the measure. The measure was then used to explore the impact of income on wellbeing using various specifications of income. The results indicate that while income is a statistically significant predictor, its effect on wellbeing is small compared with other socio-demographic variables such as health, marital status, employment status and age. The study contributes to the contemporary debate on social wellbeing and adds new evidence to a body of research that has been mainly based on European and American data