Simulering af DOC og DON i indsatsområde "Søndersø" på Fyn: Endelig rapport for Arbejdspakke 6 i projektet "Regional Grundvandsbeskyttelse ved hjælp af optimerede Økologiske Dyrkningssystemer"

Der er gennemført en beregning af udvaskning af nitrat, ammonium, DOC og DON for en konventionel og en økologisk situation i et indsatsområde ved “Søndersø” på Fyn. Beregningerne er udført med DAISY-modellen, indeholdende et nyudviklet DOC/DON-modul og MIKE SHE-modellen. Modelopsætningen, der dækker et noget større område end selve indsatsområdet, baserer sig på den eksisterende arealanvendelse og landbrugssituation for en del af området, og ekstrapoleret i den nordvestlige del. Ekstrapolationen dækker kun en lille del af det faktiske indsatsområde. Modelopsætningerne bygger på tidligere modelleringsstudier i samme område. Koncentrationerne af DOC og DON er stort set ens i de to scenarier på grund af, at den styrende faktor er jordens organiske pulje. På grund af større forekomst af græsmarker i økologisk landbrug ville man forvente en opbygning af den organiske pulje, men DAISY-modellen synes at undervurdere denne faktor. Forskellen i DOC/DON-produktion mellem konventionelt og økologisk jordbrug forventes derfor også at være undervurderet. For at beskrive DOC/DON-dynamikken i grundvandet, er den udvaskede mængde opdelt i forskellige puljer, med forskellige C/N-forhold og nedbrydningstid. Mængden af uorganisk nitrat udvasket fra rodzonen er væsentligt lavere i indsatsområdet efter omlægning til økologisk brug, nemlig 29 kg N/ha i forhold til 70 kg N/ha i gennemsnit før omlægningen. Effekten af omlægningen er noget forsinket. Nitratkoncentrationen til dræn falder fra 13.2 kg nitrat-N/ha (2003-2012) i det konventionelle scenarie til 9.5 kg nitrat-N/ha i det økologiske scenarie, opgjort som gennemsnit for de første 10 år af omlægningen (samme klimaserie og periode). For koncentrationerne i det øverste grundvandsmagasin bliver koncentrationsændringerne først rigtigt synlige mod slutningen af simuleringsperioden, men ikke i alle beregningspunkter. I 2013 er forskellen mellem den gennemsnitlige nitratkoncentration i det konventionelle og økologiske scenarie 9 procent (af koncentrationen for det konventionelle scenarie med redoxzone og DOC-nedbrydning implementeret), men det skylles at kun en lille del af det øverste magasin har en alder på 0-10 år. Fortsættes beregningerne derfor i yderligere 30 år, vil den lavere udvaskning i det økologiske scenarie også slå væsentligt kraftigere igennem på grundvandskoncentrationerne. Men man kan altså ikke forvente en umiddelbar effekt af en dyrkningsomlægning på en nitrattruet grundvandsindvinding. Omkring 52 % af nitraten, der forlader rodzonen i indsatsområdet, reduceres i redoxzonen. Da dette gælder for begge scenarier, er der i de pågældende områder ingen effekt af omlægning. DOC-betinget denitrifikation har fjernet yderligere ca 6 % af nitraten i det konventionelle scenarie. Da den nedvaskede DOC-mængde er lille i beregningerne, kan dette tal være undervurderet, især i det økologiske scenarie. På den anden side er det antaget, at alt DOC-nedbrydning medvirker til denitrifikation, hvilket er en overvurdering. Forskellen mellem denne beregning og det økologiske scenarie er kun yderligere 4 procent i 2013 (konservativ transport og konventionelt scenarie = 100 %). I denne rapport er gjort en række simple antagelser om nedbrydning, nitrifikation, denitrifikation og sorption i grundvandszonen. Antagelserne fører til en udvikling i DOC og DON, der nogenlunde svarer til generelle observationer vedrørende koncentrationer og C/N-forhold, men der foreligger ikke måledata eller detailundersøgelser, der kan anvendes til en mere detaljeret parameterisering og procesforståelse. For at opnå en bedre forståelse af betydningen af DOC-produktion på denitrifikation, ikke mindst i økologisk produktion, kræves derfor yderligere undersøgelser

Short Bowel Patients Treated for Two Years with Glucagon-Like Peptide 2 (GLP-2): Compliance, Safety, and Effects on Quality of Life

Background and aims. Glucagon-like peptide 2 (GLP-2) has been shown to improve intestinal absorption in short bowel syndrome (SBS) patients in a short-term study. This study describes safety, compliance, and changes in quality of life in 11 SBS patients at baseline, week 13, 26, and 52 during two years of subcutaneous GLP-2 treatment, 400 microgram TID, intermitted by an 8-week washout period. Methods. Safety and compliance was evaluated during the admissions. The Sickness Impact Profile (SIP), Short Form 36 (SF 36), and Inflammatory Bowel Disease Questionnaire (IBDQ) evaluated quality of life. Results. The predominant adverse event was transient abdominal discomfort in 5 of 11 patients, but in 2, both suffering from Crohns disease, it progressed to abdominal pain and led to discontinuation of GLP-2 treatment. One had a fibrostenotic lesion electively resected at the jejuno-ascendo-anastomosis. The investigator excluded a patient due to unreliable feedback. Stoma nipple enlargement was seen in all 9 jejunostomy patients. Reported GLP-2 compliance was excellent (>93%). GLP-2 improved the overall quality of life VAS-score (4.1 ± 2.8 cm versus 6.0 ± 2.4 cm, P < .01), the overall SIP score (10.3 ± 8.9% versus 6.2 ± 9.5%, P < .001), the mental component of the SF-36 (45 ± 13% versus 53 ± 11%, P < .05), and the overall IBDQ score (5.1 ± 0.9 versus 5.4 ± 0.9, P < .007) in the 8 patients completing the study. Conclusions. Long-term treatment with GLP-2 is feasible in SBS patients, although caution must be exercised in patients with a history of abdominal pain. Although conclusions cannot be made in a noncontrolled trial, the high reported compliance might reflect a high treatment satisfaction, where the clinical benefits of GLP-2 may outweigh the discomforts of injections

Short Bowel Patients Treated for Two Years with Glucagon-Like Peptide 2: Effects on Intestinal Morphology and Absorption, Renal Function, Bone and Body Composition, and Muscle Function

Background and aims. In a short-term study, Glucagon-like peptide 2 (GLP-2) has been shown to improve intestinal absorption in short bowel syndrome (SBS) patients. This study describes longitudinal changes in relation to GLP-2 treatment for two years. Methods. GLP-2, 400 micrograms, s.c.,TID, were offered, to eleven SBS patients keeping parenteral support constant. 72-hour nutritional balance studies were performed at baseline, weeks 13, 26, 52 during two years intermitted by an 8-week washout period. In addition, mucosal morphometrics, renal function (by creatinine clearance), body composition and bone mineral density (by DEXA), biochemical markers of bone turnover (by s-CTX and osteocalcin, PTH and vitamin D), and muscle function (NMR, lungfunction, exercise test) were measured. Results. GLP-2 compliance was >93%. Three of eleven patients did not complete the study. In the remaining 8 patients, GLP-2 significantly reduced the fecal wet weight from approximately 3.0 to approximately 2.0 kg/day. This was accompanied by a decline in the oral wet weight intake, maintaining intestinal wet weight absorption and urinary weight constant. Renal function improved. No significant changes were demonstrated in energy intake or absorption, and GLP-2 did not significantly affect mucosal morphology, body composition, bone mineral density or muscle function. Conclusions. GLP-2 treatment reduces fecal weight by approximately 1000 g/d and enables SBS patients to maintain their intestinal fluid and electrolyte absorption at lower oral intakes. This was accompanied by a 28% improvement in creatinine clearance

Influence of oxygen ordering kinetics on Raman and optical response in YBa_2Cu_3O_{6.4}

Kinetics of the optical and Raman response in YBa_2Cu_3O_{6.4} were studied during room temperature annealing following heat treatment. The superconducting T_c, dc resistivity, and low-energy optical conductivity recover slowly, implying a long relaxation time for the carrier density. Short relaxation times are observed for the B_{1g} Raman scattering -- magnetic, continuum, and phonon -- and the charge transfer band. Monte Carlo simulations suggest that these two relaxation rates are related to two length scales corresponding to local oxygen ordering (fast) and long chain and twin formation (slow).Comment: REVTeX, 3 pages + 4 PostScript (compressed) figure

A multiple length scale description of the mechanism of elastomer stretching

Conventionally, the stretching of rubber is modeled exclusively by rotations of segments of the embedded polymer chains; i.e. changes in entropy.</p

Development status of a Laue lens project for gamma-ray astronomy

We report the status of the HAXTEL project, devoted to perform a design study and the development of a Laue lens prototype. After a summary of the major results of the design study, the approach adopted to develop a Demonstration Model of a Laue lens is discussed, the set up described, and some results presented.Comment: 11 pages, 11 figures, 2007 SPIE Conference on Optics for EUV, X-Ray, and Gamma-Ray Astronomy II

Impact of rs361072 in the Phosphoinositide 3-Kinase p110β Gene on Whole-Body Glucose Metabolism and Subunit Protein Expression in Skeletal Muscle

OBJECTIVE-Phosphoinositide 3-kinase (PI3K) is a major effector in insulin signaling. rs361072, located in the promoter of the gene (PIK3CB) for the p110 beta subunit, has previously been found to be associated with homeostasis model assessment for insulin resistance (HOMA-IR) in obese subjects. The aim was to investigate the influence of rs361072 on in vivo glucose metabolism, skeletal muscle PI3K subunit protein levels, and type 2 diabetes. RESEARCH DESIGN AND METHODS-The functional role of rs361072 was studied in 196 Danish healthy adult twins. Peripheral and hepatic insulin sensitivity was assessed by a euglycemic-hyperinsulinemic clamp. Basal and insulin-stimulated biopsies were taken from the vastus lateralis muscle, and tissue p110 beta and p85 alpha proteins were measured by Western blotting. The genetic association with type 2 diabetes and quantitative metabolic traits was investigated in 9,316 Danes with glucose tolerance ranging from normal to overt type 2 diabetes. RESULTS-While hepatic insulin resistance was similar in the fasting state, carriers of the minor G allele had lower hepatic glucose output (per-allele effect: 16%, P-add = 0.004) during high physiological insulin infusion. rs361072 did not associate with insulin-stimulated peripheral glucose disposal despite a decreased muscle p85 alpha:p110 beta protein ratio (P-add = 0.03) in G allele carriers. No association with HOMA-IR or type 2 diabetes (odds ratio 1.07, P = 0.5) was identified, and obesity did not interact with rs361072 on these traits. CONCLUSIONS-Our study suggests that the minor G allele of PIK3CB rs361072 associates with decreased muscle p85 alpha:p110 beta ratio and lower hepatic glucose production at high plasma insulin levels. However, no impact on type 2 diabetes prevalence was found. Diabetes 59:1108-1112, 201

Semi-Static Hedging Based on a Generalized Reflection Principle on a Multi Dimensional Brownian Motion

On a multi-assets Black-Scholes economy, we introduce a class of barrier options. In this model we apply a generalized reflection principle in a context of the finite reflection group acting on a Euclidean space to give a valuation formula and the semi-static hedge.Comment: Asia-Pacific Financial Markets, online firs