4,534 research outputs found
Preferential Services and Investment Agreements in Asia: Implications for Switzerland, in: Sur la voie du bilatéralisme: enjeux et conséquences (volume 1) (Etudes mandatées par le Secrétariat d'Etat à l'économie SECO), pp. 183-333
Regulation and Function of FTO mRNA Expression in Human Skeletal Muscle and Subcutaneous Adipose Tissue
OBJECTIVE-Common variants in FTO (the fat mass- and obesity-associated gene) associate with obesity and type 2 diabetes. The regulation and biological function of FTO mRNA expression in target tissue is unknown. We investigated the genetic and nongenetic regulation of FTO mRNA in skeletal muscle and adipose tissue and their influence on in vivo glucose and fat metabolism. RESEARCH DESIGN AND METHODS-The FTO rs9939609 polymorphism was genotyped in two twin cohorts: 1) 298 elderly twins aged 62-83 years with glucose tolerance ranging from normal to type 2 diabetes and 2) 196 young (25-32 years) and elderly (58-66 years) nondiabetic twins examined by a hyperinsulinemic-euglycemic clamp including indirect calorimetry. FTO mRNA expression was determined in subcutaneous adipose tissue (n = 226) and skeletal muscle biopsies (n = 158). RESULTS-Heritability of FTO expression in both tissues was low, and FTO expression was not influenced by FTO rs9939609 genotype. FTO mRNA expression in skeletal muscle was regulated by age and sex, whereas age and BMI were predictors of adipose tissue FTO mRNA expression. FTO mRNA expression in adipose tissue was associated with an atherogenic lipid profile. In skeletal muscle, FTO mRNA expression was negatively associated to fat and positively to glucose oxidation rates as well as positively correlated with expression of genes involved in oxidative phosphorylation including PGC1 alpha. CONCLUSIONS-The heritability of FTO expression in adipose tissue and skeletal muscle is low and not influenced by obesity-associated FTO genotype. The age-dependent decline in FTO expression is associated with peripheral defects of glucose and fat metabolism. Diabetes 58:2402-2408, 200
Atomic quantum superposition state generation via optical probing
We analyze the performance of a protocol to prepare an atomic ensemble in a
superposition of two macroscopically distinguishable states. The protocol
relies on conditional measurements performed on a light field, which interacts
with the atoms inside an optical cavity prior to detection, and we investigate
cavity enhanced probing with continuous beams of both coherent and squeezed
light. The stochastic master equations used in the analysis are expressed in
terms of the Hamiltonian of the probed system and the interaction between the
probed system and the probe field and are thus quite generally applicable.Comment: 10 pages, 9 figure
Manipulating the torsion of molecules by strong laser pulses
A proof-of-principle experiment is reported, where torsional motion of a
molecule, consisting of a pair of phenyl rings, is induced by strong laser
pulses. A nanosecond laser pulse spatially aligns the carbon-carbon bond axis,
connecting the two phenyl rings, allowing a perpendicularly polarized, intense
femtosecond pulse to initiate torsional motion accompanied by an overall
rotation about the fixed axis. The induced motion is monitored by femtosecond
time-resolved Coulomb explosion imaging. Our theoretical analysis accounts for
and generalizes the experimental findings.Comment: 4 pages, 4 figures, submitted to PRL; Major revision of the
presentation of the material; Correction of ion labels in Fig. 2(a
Differential atom interferometry beyond the standard quantum limit
We analyze methods to go beyond the standard quantum limit for a class of
atomic interferometers, where the quantity of interest is the difference of
phase shifts obtained by two independent atomic ensembles. An example is given
by an atomic Sagnac interferometer, where for two ensembles propagating in
opposite directions in the interferometer this phase difference encodes the
angular velocity of the experimental setup. We discuss methods of squeezing
separately or jointly observables of the two atomic ensembles, and compare in
detail advantages and drawbacks of such schemes. In particular we show that the
method of joint squeezing may improve the variance by up to a factor of 2. We
take into account fluctuations of the number of atoms in both the preparation
and the measurement stage, and obtain bounds on the difference of the numbers
of atoms in the two ensembles, as well as on the detection efficiency, which
have to be fulfilled in order to surpass the standard quantum limit. Under
realistic conditions, the performance of both schemes can be improved
significantly by reading out the phase difference via a quantum non-demolition
(QND) measurement. Finally, we discuss a scheme using macroscopically entangled
ensembles.Comment: 10 pages, 5 figures; eq. (3) corrected and other minor change
Development status of a Laue lens project for gamma-ray astronomy
We report the status of the HAXTEL project, devoted to perform a design study
and the development of a Laue lens prototype. After a summary of the major
results of the design study, the approach adopted to develop a Demonstration
Model of a Laue lens is discussed, the set up described, and some results
presented.Comment: 11 pages, 11 figures, 2007 SPIE Conference on Optics for EUV, X-Ray,
and Gamma-Ray Astronomy II
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