EFFICACY OF ULTRASOUND WITH MAITLAND MOBILIZATION OVER SHORT WAVE DIATHERMY WITH MAITLAND MOBILIZATION IN IMPROVING THE FUNCTIONAL PERFORMANCE OF PATIENTS WITH PERIARTHRITIS SHOULDER

Objective: To investigate the effectiveness of ultrasound with Maitland mobilization over Short wave diathermy with Maitland mobilization in improving the functional performance of patients with Periarthritis of shoulder Design: A simple randomized controlled clinical trail Setting: The study was conducted in the department of physiotherapy in Ganga Hospital Coimbatore (India), Vinayaka Mission Hospital Salem (India). Subjects: 30 patients were selected randomly from the population using simple random sampling procedure (Lottery Method) and were divided into two equal groups. Intervention : The experimental group (n=15) were given Ultrasound with Maitland mobilization with 1 MHz in frequency, continuous mode and 1.5 W/cm 2 of intensity with 5cm 2 sized transducer for 10 minutes of treatment duration .The control group (n=15) were given Short wave diathermy with Maitland mobilization for period of 15 min with contra planar technique. Outcome measures: The functional performance was measured using Shoulder Pain and Disability Index (SPADI) scale. Results: In Group-A (Experimental Group ) and Group-B (Control Group), all data was expressed as mean ± , SD and was statistically analysed using paired 't' test and independent 't' test to determine the statistical difference among the parameters at 0.5% level of significance. Statistical data of SPADI showed that, Group-A is significantly different from Group-B with p<0.05; i.e 95% of significance. Conclusion: The post ultrasound Maitland mobilization is found more effective and beneficial than post SWD Maitland mobilization on shoulder functions in periarthritis. KEYWORDS: Maitland mobilizations, Short wave diathermy, Ultrasound, Periarthritis, Glides. Quick Response cod

LC–HRMS determination of piperine on rat dried blood spots: A pharmacokinetic study

A liquid chromatography–high resolution mass spectrometry (LC–HRMS) method was developed and validated for the determination of piperine (PPR) on dried blood spots (DBS). DBS samples were prepared by spiking the whole blood with analyte to produce 30 µL of blood spots on specimen collection cards. Chromatographic separation was achieved on an Atlantis dC18 column using acetonitrile and water (0.1% formic acid) (85:15, v/v) as mobile phase in an isocratic mode of elution at a flow rate of 0.75 mL/min. MS detection was carried out in electrospray positive ion mode for the target ions and monitored at m/z 286.1465 for PPR and 272.1303 for the internal standard (IS). The developed method exhibited a linear dynamic range over 0.01–2000 ng/mL for PPR on DBS. The overall extraction recovery of PPR from DBS was 92.5%. Influence of hematocrit and spot volume on DBS was also evaluated and found to be well within the acceptable limits. The method was successfully applied to pharmacokinetic studies of PPR in rats

The first but not the second thrombospondin type 1 repeat of ADAMTS5 functions as an angiogenesis inhibitor

10.1016/j.bbrc.2008.04.047Biochemical and Biophysical Research Communications3712215-219BBRC

Isthmin is a novel secreted angiogenesis inhibitor that inhibits tumour growth in mice

10.1111/j.1582-4934.2009.00961.xJournal of Cellular and Molecular Medicine152359-37