Records of the Greenside Darter, Etheostoma Blennioides from the Susquehanna River Drainage in Pennsylvania

Author Institution: Department of Biological Sciences, York College of Pennsylvania; Department of Biology and Center for Environmental Studies, Virginia Polytechnic Institute and State University and Appalachian Environmental Laboratory, University of Maryland, Frostburg State College CampusA population of the greenside darter, Etheostoma blennioides Rafinesque, is recorded for the first time from the Susquehanna River drainage. Meristics are significantly different from populations in the adjacent Allegheny and upper Genesee drainages for dorsal rays and least caudal peduncle scales. Taxonomic comparison places it in the subspecies E. b. blennioides. The population is believed to have entered the Susquehanna drainage via stream capture from the Allegheny. Its presence until now has been undetected because emphasis on taxonomic-distributional research has centered in other geographic areas

Intimate Partner Violence Among Men and Women in South Carolina, 1998

Few studies provide population-based estimates of intimate partner violence (IPV) for men and women, especially at the state level. IPV may result in adverse health effects for victims and perpetrators (1-3). To estimate the lifetime incidence of IPV by type of violence (e.g., physical, sexual, and perceived emotional abuse) and to explore demographic correlates of reporting IPV among men and women, the South Carolina Department of Health and Environmental Control and the University of South Carolina conducted a population-based random-digit-dialed telephone survey of adults in the state. This report summarizes the results of the survey, which indicated that approximately 25% of women and 13% of men have experienced some type of IPV during their lifetime. Although women were significantly more likely to report physical and sexual IPV, men were as likely as women to report emotional abuse without concurrent physical or sexual IPV

Fibroblast growth factors 1 and 2 in cerebrospinal fluid are associated with HIV disease, methamphetamine use, and neurocognitive functioning.

BackgroundHuman immunodeficiency virus (HIV) and methamphetamine use commonly affect neurocognitive (NC) functioning. We evaluated the relationships between NC functioning and two fibroblast growth factors (FGFs) in volunteers who differed in HIV serostatus and methamphetamine dependence (MAD).MethodsA total of 100 volunteers were categorized into four groups based on HIV serostatus and MAD in the prior year. FGF-1 and FGF-2 were measured in cerebrospinal fluid by enzyme-linked immunosorbent assays along with two reference biomarkers (monocyte chemotactic protein [MCP]-1 and neopterin). Comprehensive NC testing was summarized by global and domain impairment ratings.ResultsSixty-three volunteers were HIV+ and 59 had a history of MAD. FGF-1, FGF-2, and both reference biomarkers differed by HIV and MAD status. For example, FGF-1 levels were lower in subjects who had either HIV or MAD than in HIV- and MAD- controls (P=0.003). Multivariable regression identified that global NC impairment was associated with an interaction between FGF-1 and FGF-2 (model R(2)=0.09, P=0.01): higher FGF-2 levels were only associated with neurocognitive impairment among subjects who had lower FGF-1 levels. Including other covariates in the model (including antidepressant use) strengthened the model (model R(2)=0.18, P=0.004) but did not weaken the association with FGF-1 and FGF-2. Lower FGF-1 levels were associated with impairment in five of seven cognitive domains, more than FGF-2, MCP-1, or neopterin.ConclusionThese findings provide in vivo support that HIV and MAD alter expression of FGFs, which may contribute to the NC abnormalities associated with these conditions. These cross-sectional findings cannot establish causality and the therapeutic benefits of recombinant FGF-1 need to be investigated

Tertiary halo and tertiary background in the low luminosity experimental insertion IR8 of the LHC

In our report we present the results for numerical simulation of tertiary halo and tertiary background in the LHC. We study the case of the proton losses in the betatron cleaning insertion IR7 with the subsequent tertiary halo generation in the downstream experimental insertion IR8. We analyze the formation of tertiary background in the experimental area of the IR8 and evaluate the performance of the machine-detector interface shielding with respect to this source of the background. The results obtained are compared with the previous estimates of the machine-induced background in the low luminosity insertions of the LHC, and the balance between different sources of the background is discussed

Intrusion of warm Bering/Chukchi waters onto the shelf in the western Beaufort Sea

Author Posting. © American Geophysical Union, 2009. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research 114 (2009): C00A11, doi:10.1029/2008JC004870.Wind-driven changes in the path of warm Bering/Chukchi waters carried by the Alaska Coastal Current (ACC) through Barrow Canyon during late summer are described from high-resolution hydrography, acoustic Doppler current profiler–measured currents, and satellite-measured sea surface temperature imagery acquired from mid-August to mid-September 2005–2007 near Barrow, Alaska. Numerical simulations are used to provide a multidecadal context for these observational data. Four generalized wind regimes and associated circulation states are identified. When winds are from the east or east-southeast, the ACC jet tends to be relatively strong and flows adjacent to the shelf break along the southern flank of Barrow Canyon. These easterly winds drive inner shelf currents northwestward along the Alaskan Beaufort coast where they oppose significant eastward intrusions of warm water from Barrow Canyon onto the shelf. Because these easterly winds promote sea level set down over the Beaufort shelf and upwelling along the Beaufort slope, the ACC jet necessarily becomes weaker, broader, and displaced seaward from the Beaufort shelf break upon exiting Barrow Canyon. Winds from the northeast promote separation of the ACC from the southern flank of Barrow Canyon and establish an up-canyon current along the southern flank that is fed in part by waters from the western Beaufort shelf. When winds are weak or from the southwest, warm Bering/Chukchi waters from Barrow Canyon intrude onto the western Beaufort shelf.This work was supported in 2005 and 2006 by NSF grants OPP-0436131 and OPP-0436166. In 2007, this work received support through Woods Hole Oceanographic Institution- NOAA Cooperative Institute for Climate and Ocean Research Cooperative Agreement NA17RJ1223 and University of Alaska Fairbanks-NOAA Cooperative Institute for Arctic Research Cooperative Agreement NA17RJ1224. Additional support was provided by the James M. and Ruth P. Clark Arctic Research Initiative Fund at the Woods Hole Oceanographic Institution

Homologous and heterologous desensitization of guanylyl cyclase-B signaling in GH3 somatolactotropes

The guanylyl cyclases, GC-A and GC-B, are selective receptors for atrial and C-type natriuretic peptides (ANP and CNP, respectively). In the anterior pituitary, CNP and GC-B are major regulators of cGMP production in gonadotropes and yet mouse models of disrupted CNP and GC-B indicate a potential role in growth hormone secretion. In the current study, we investigate the molecular and pharmacological properties of the CNP/GC-B system in somatotrope lineage cells. Primary rat pituitary and GH3 somatolactotropes expressed functional GC-A and GC-B receptors that had similar EC50 properties in terms of cGMP production. Interestingly, GC-B signaling underwent rapid homologous desensitization in a protein phosphatase 2A (PP2A)-dependent manner. Chronic exposure to either CNP or ANP caused a significant down-regulation of both GC-A- and GC-B-dependent cGMP accumulation in a ligand-specific manner. However, this down-regulation was not accompanied by alterations in the sub-cellular localization of these receptors. Heterologous desensitization of GC-B signaling occurred in GH3 cells following exposure to either sphingosine-1-phosphate or thyrotrophin-releasing hormone (TRH). This heterologous desensitization was protein kinase C (PKC)-dependent, as pre-treatment with GF109203X prevented the effect of TRH on CNP/GC-B signaling. Collectively, these data indicate common and distinct properties of particulate guanylyl cyclase receptors in somatotropes and reveal that independent mechanisms of homologous and heterologous desensitization occur involving either PP2A or PKC. Guanylyl cyclase receptors thus represent potential novel therapeutic targets for treating growth-hormone-associated disorders

Scholarship in Review 87(1)

Scholarship in Review was a magazine highlighting research and scholarly activities at Central Washington University, published by the Office of Graduate Studies and Research.https://digitalcommons.cwu.edu/scholarship_in_review/1003/thumbnail.jp

Sixteen years of Collaborative Learning through Active Sense-making in Physics (CLASP) at UC Davis

This paper describes our large reformed introductory physics course at UC Davis, which bioscience students have been taking since 1996. The central feature of this course is a focus on sense-making by the students during the five hours per week discussion/labs in which the students take part in activities emphasizing peer-peer discussions, argumentation, and presentations of ideas. The course differs in many fundamental ways from traditionally taught introductory physics courses. After discussing the unique features of CLASP and its implementation at UC Davis, various student outcome measures are presented showing increased performance by students who took the CLASP course compared to students who took a traditionally taught introductory physics course. Measures we use include upper-division GPAs, MCAT scores, FCI gains, and MPEX-II scores.Comment: Also submitted to American Journal of Physic

Evaluation of the NG-Test CARBA 5 lateral flow assay with an IMP-2-producing Morganella morganii and other Morganellaceae

An isolate of Morganella morganii (MMOR1) that tested susceptible to