Prefigurative politics between ethical practice and absent promise

'Prefigurative politics' has become a popular term for social movements' ethos of unity between means and ends, but its conceptual genealogy has escaped attention. This article disentangles two components: an ethical revolutionary practice, chiefly indebted to the anarchist tradition, which fights domination while directly constructing alternatives; and prefiguration as a recursive temporal framing, unknowingly drawn from Christianity, in which a future radiates backwards on its past. Tracing prefiguration from the Church Fathers to politicised re-surfacings in the Diggers and the New Left, I associate it with Koselleck's 'process of reassurance' in a pre-ordained historical path. Contrasted to recursive prefiguration are the generative temporal framings couching defences of means-ends unity in the anarchist tradition. These emphasised the path dependency of revolutionary social transformation and the ethical underpinnings of anti-authoritarian politics. Misplaced recursive terminology, I argue, today conveniently distracts from the generative framing of means-ends unity, as the promise of revolution is replaced by that of environmental and industrial collapse. Instead of prefiguration, I suggest conceiving of means-ends unity in terms of Bloch's 'concrete utopia', and associating it with 'anxious' and 'catastrophic' forms of hope

Maize genetics Committee on Outreach, Diversity, Inclusion, and Education (CODIE) 2020-2021 update.

Virtual meeting

Targeting the hypoxic fraction of tumours using hypoxia activated prodrugs

The presence of a microenvironment within most tumours containing regions of low oxygen tension or hypoxia has profound biological and therapeutic implications. Tumour hypoxia is known to promote the development of an aggressive phenotype, resistance to both chemotherapy and radiotherapy and is strongly associated with poor clinical outcome. Paradoxically, it is recognised as a high priority target and one therapeutic strategies designed to eradicate hypoxic cells in tumours are a group of compounds known collectively as hypoxia activated prodrugs (HAPs) or bioreductive drugs. These drugs are inactive prodrugs that require enzymatic activation (typically by 1 or 2 electron oxidoreductases) to generate cytotoxic species with selectivity for hypoxic cells being determined by (i) the ability of oxygen to either reverse or inhibit the activation process and (ii) the presence of elevated expression of oxidoreductases in tumours. The concepts underpinning HAP development were established over 40 years ago and have been refined over the years to produce a new generation of HAPs that are under preclinical and clinical development. The purpose of this article is to describe current progress in the development of HAPs focusing on the mechanisms of action, preclinical properties and clinical progress of leading examples

Iron and zinc absorption in human subjects from a mixed meal of extruded and nonextruded wheat bran and flour

The effect of extrusion cooking of a bran-flour mixture on iron and zinc retention was measured in normal adults. The stable isotopes 58Fe (1.253 mg) and 67Zn (5.13 mg) were administered with 40 g nonextruded or extruded cereal with milk and isotopic retention was measured from fecal excretion over the next 4-7 d by neutron-activation analysis (Fe) and fast-atom-bombardment mass spectrometry (Zn). 58Fe retention was 15.1 +/- 2.4% (means +/- SEM) with the nonextruded meal and 16.5 +/- 2.7% with the extruded meal. 67Zn retention was 18.9 +/- 1.7% with the nonextruded meal and 18.3 +/- 1.5% with the extruded meal. Extrusion cooking had no effect on 58Fe or 67Zn retention

Work-based learning at higher education level: value, practice and critique

Since the 1980s there has been significant growth in the engagement of higher education with workforce development, with among other things the emergence of a distinct if varied area of provision commonly referred to as work-based learning. Recent examination of practice and literature indicates a growing sophistication in the way that work-based learning is being theorised and facilitated in higher education, with its gradual emergence as a distinct field of practice and study supported by relevant pedagogies and concepts of curriculum. Tensions continue to exist between the demands and opportunities provided by the workplace and the need to develop capable practice, support personal development and maintain academic validity; however, universities are beginning to engage with these issues at a deeper level than that suggested by simple notions of employer engagement and skills development, and the evidence indicates that well-designed work-based programmes are both effective and robust