Calculation of the Voronoi boundary for lens-shaped particles and spherocylinders

We have recently developed a mean-field theory to estimate the packing fraction of non-spherical particles [A. Baule et al., Nature Commun. (2013)]. The central quantity in this framework is the Voronoi excluded volume, which generalizes the standard hard-core excluded volume appearing in Onsager's theory. The Voronoi excluded volume is defined from an exclusion condition for the Voronoi boundary between two particles, which is usually not tractable analytically. Here, we show how the technical difficulties in calculating the Voronoi boundary can be overcome for lens-shaped particles and spherocylinders, two standard prolate and oblate shapes with rotational symmetry. By decomposing these shapes into unions and intersections of spheres analytical expressions can be obtained.Comment: 19 pages, 8 figure

Shielding analysis in the design phase of the new Emergency Operation Facility for Tihange Nuclear Power Plant

In the framework of the design studies for a new Emergency Operation Facility (EOF) for Tihange NPP, radiation protection analyses are needed to comply with effective dose rate criteria. In this aim, the shielding performed by, at the one hand, external walls and roof of the building and, on the other hand, internal walls, has been sized by means of MicroShield calculations. This paper explains how the calculations for external walls, doors, roof, floor and internal walls are made. The assumptions on the source terms and on the source geometry as well as the way the shielding is determined and the results of the sizing are presented

EuReCa ONE—27 Nations, ONE Europe, ONE Registry A prospective one month analysis of out-of-hospital cardiac arrest outcomes in 27 countries in Europe

AbstractIntroductionThe aim of the EuReCa ONE study was to determine the incidence, process, and outcome for out of hospital cardiac arrest (OHCA) throughout Europe.MethodsThis was an international, prospective, multi-centre one-month study. Patients who suffered an OHCA during October 2014 who were attended and/or treated by an Emergency Medical Service (EMS) were eligible for inclusion in the study. Data were extracted from national, regional or local registries.ResultsData on 10,682 confirmed OHCAs from 248 regions in 27 countries, covering an estimated population of 174 million. In 7146 (66%) cases, CPR was started by a bystander or by the EMS. The incidence of CPR attempts ranged from 19.0 to 104.0 per 100,000 population per year. 1735 had ROSC on arrival at hospital (25.2%), Overall, 662/6414 (10.3%) in all cases with CPR attempted survived for at least 30 days or to hospital discharge.ConclusionThe results of EuReCa ONE highlight that OHCA is still a major public health problem accounting for a substantial number of deaths in Europe.EuReCa ONE very clearly demonstrates marked differences in the processes for data collection and reported outcomes following OHCA all over Europe. Using these data and analyses, different countries, regions, systems, and concepts can benchmark themselves and may learn from each other to further improve survival following one of our major health care events

Shielding analysis in the design phase of the new Emergency Operation Facility for Tihange Nuclear Power Plant

In the framework of the design studies for a new Emergency Operation Facility (EOF) for Tihange NPP, radiation protection analyses are needed to comply with effective dose rate criteria. In this aim, the shielding performed by, at the one hand, external walls and roof of the building and, on the other hand, internal walls, has been sized by means of MicroShield calculations. This paper explains how the calculations for external walls, doors, roof, floor and internal walls are made. The assumptions on the source terms and on the source geometry as well as the way the shielding is determined and the results of the sizing are presented

Shielding analysis in the design phase of the new Emergency Operation Facility for Tihange Nuclear Power Plant

In the framework of the design studies for a new Emergency Operation Facility (EOF) for Tihange NPP, radiation protection analyses are needed to comply with effective dose rate criteria. In this aim, the shielding performed by, at the one hand, external walls and roof of the building and, on the other hand, internal walls, has been sized by means of MicroShield calculations. This paper explains how the calculations for external walls, doors, roof, floor and internal walls are made. The assumptions on the source terms and on the source geometry as well as the way the shielding is determined and the results of the sizing are presented

Amélioration des connaissances géologiques de l'aquifère de la craie (Nord de la France) par imagerie TRE à des fins hydrogéologiques

International audienceThis study is part of a large multidisciplinary project aiming at characterize the geometry of the Chalk aquifer and its structures (faults, fracturing…), in two well fields in the South of Lille metropolis (Northern France), for hydrogeology purposes, especially drinking water production. We focus on two main results obtained through Electrical Resistivity Tomography (ERT) imaging. First, we define a petrophysical-linked electrical signature of the Chalk that allows us to image the hydrogeological stratification of the aquifer. Then, we refine the geological settings of the largest and the most exploited (in terms of water resource) well field which is also the most affected by water quality problems. We identify a fracturing corridor inside the unaltered Chalk and we precise the geometry of the overlying Tertiary formations (Louvil Clays). The refinement of the geological structures enhances our understanding of the Chalk hydrosystem functioning that represents a key issue to guarantee the sustainable management of a water resource

Early Astrocytic Dysfunction Is Associated with Mistuned Synapses as well as Anxiety and Depressive-Like Behavior in the AppNL-F Mouse Model of Alzheimer's Disease

Background: Alzheimer’s disease (AD) is the most common neurodegenerative disease. Unfortunately, efficient and affordable treatments are still lacking for this neurodegenerative disorder, it is therefore urgent to identify new pharmacological targets. Astrocytes are playing a crucial role in the tuning of synaptic transmission and several studies have pointed out severe astrocyte reactivity in AD. Reactive astrocytes show altered physiology and function, suggesting they could have a role in the early pathophysiology of AD. Objective: We aimed to characterize early synaptic impairments in the AppNL-F knock-in mouse model of AD, especially to understand the contribution of astrocytes to early brain dysfunctions. Methods: The AppNL-F mouse model carries two disease-causing mutations inserted in the amyloid precursor protein gene. This strain does not start to develop amyloid-β plaques until 9 months of age. Thanks to electrophysiology, we investigated synaptic function, at both neuronal and astrocytic levels, in 6-month-old animals and correlate the synaptic activity with emotional behavior. Results: Electrophysiological recordings in the hippocampus revealed an overall synaptic mistuning at a pre-plaque stage of the pathology, associated to an intact social memory but a stronger depressive-like behavior. Astrocytes displayed a reactive-like morphology and a higher tonic GABA current compared to control mice. Interestingly, we here show that the synaptic impairments in hippocampal slices are partially corrected by a pre-treatment with the monoamine oxidase B blocker deprenyl or the fast-acting antidepressant ketamine (5 mg/kg). Conclusions: We propose that reactive astrocytes can induce synaptic mistuning early in AD, before plaques deposition, and that these changes are associated with emotional symptoms

Early Astrocytic Dysfunction Is Associated with Mistuned Synapses as well as Anxiety and Depressive-Like Behavior in the AppNL-F Mouse Model of Alzheimer's Disease

Background: Alzheimer’s disease (AD) is the most common neurodegenerative disease. Unfortunately, efficient and affordable treatments are still lacking for this neurodegenerative disorder, it is therefore urgent to identify new pharmacological targets. Astrocytes are playing a crucial role in the tuning of synaptic transmission and several studies have pointed out severe astrocyte reactivity in AD. Reactive astrocytes show altered physiology and function, suggesting they could have a role in the early pathophysiology of AD. Objective: We aimed to characterize early synaptic impairments in the AppNL-F knock-in mouse model of AD, especially to understand the contribution of astrocytes to early brain dysfunctions. Methods: The AppNL-F mouse model carries two disease-causing mutations inserted in the amyloid precursor protein gene. This strain does not start to develop amyloid-β plaques until 9 months of age. Thanks to electrophysiology, we investigated synaptic function, at both neuronal and astrocytic levels, in 6-month-old animals and correlate the synaptic activity with emotional behavior. Results: Electrophysiological recordings in the hippocampus revealed an overall synaptic mistuning at a pre-plaque stage of the pathology, associated to an intact social memory but a stronger depressive-like behavior. Astrocytes displayed a reactive-like morphology and a higher tonic GABA current compared to control mice. Interestingly, we here show that the synaptic impairments in hippocampal slices are partially corrected by a pre-treatment with the monoamine oxidase B blocker deprenyl or the fast-acting antidepressant ketamine (5 mg/kg). Conclusions: We propose that reactive astrocytes can induce synaptic mistuning early in AD, before plaques deposition, and that these changes are associated with emotional symptoms

Comment améliorer la connaissance géologique de l'aquifère de la craie à des fins hydrogéologiques ? Approche géophysique multiméthode focalisante appliquée aux champs captants du sud de Lille

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