Comparative study of collagen and gelatin coatings on titanium surfaces

The vast majority of studies in the bone tissue engineering field are focused on the surface modification of titanium scaffolds to obtain integration of the scaffold in the surrounding bone tissue. Our approach consisted in benefiting from the advantages of the cell-interaction capabilities of collagen and gelatin. The biopolymers were immobilised onto the Ti surface through different methods and the stability of the obtained coatings was determined. The obtained results reveal that covalent immobilisation of collagen and gelatin is required to obtain stable surface coatings

Suivi du greffage peptidique de biomatériaux par spectroscopie XPS

La biocompatibilité d'un matériel implantable est essentielle..

Suivi du greffage peptidique de biomatériaux par spectroscopie XPS

La biocompatibilité d'un matériel implantable est essentielle..

Surface treatment of biomaterials by gamma and swift heavy ions grafting

International audienc

Grafting of RGD peptides to cellulose to enhance human osteoprogenitor cells adhesion and proliferation

Despite the controversy about the ideal properties of bone replacement materials, it seems that the concept of tissue engineered constructs, materials pre-colonized with autologous bone cells before implantation gathers most of favorable opinions. Cellulosic materials possess osteoconductive properties but have no intrinsic osteoinductive capacity..

Impact of RGD Nanopatterns Grafted onto Titanium on Osteoblastic Cell Adhesion

This work reports on the synthesis of titanium bone implants functionalized with nanoparticles (NPs) containing Arg-Gly-Asp-Cys peptide (RGDC) and shows the adhesion behavior of cells seeded on these materials. RGDC peptides were first: conjugated to a norbornenyl-poly(ethylene oxide) macromonomer (Nb-PEO). Then, functional NPs with a size of similar to 300 nm and constituted of polynorbornene core surrounded by poly(ethylene oxide) shell were prepared by ring-opening metathesis polymerization in dispersed medium. The grafting density of these NPs on the titanium surface is up to 2 NPs.mu m(-2) (80 pmol of RGDC per cm(-2) of NP surface). Cell adhesion was evaluated using preosteoblast cells (MC3T3-E1). Results of cells cultured for 24 h showed that materials grafted with NPs functionalized with RGDC peptides enhance specific cell adhesion and can create filopodia-like among NP sites by stressing the cells