Cost-effectiveness plane.

<p>Monte Carlo simulation results on cost-effectiveness plane for the expanded newborn screening showing interval estimates for cost, outcome and incremental cost-effectiveness ratio. The figure shows the horizontal I-bar representing the 95% uncertainty interval on life-year gained, the vertical I-bar representing the 95% uncertainty interval on incremental cost, and the wedge represent the 95% uncertainty interval on the ICER. THB = Thai baht; ICER = incremental cost effectiveness ratio.</p

Simplified-decision-tree.

<p>Comparing the strategies of expanding the newborn screening programme with the pre-expanded newborn screening programme. MS/MS = Tandem mass spectrometry; PKU = phenylketonuria; M = Markov model.</p

Markov model.

<p>Health states transition of selected IEM. (A) represents PKU, IVA, MSUD and MCD; (B) represents MMA; and (C) represents PA. PKU = phenylketonuria; IVA = isovaleric acidemia; MMA = methylmalonic acidemia; PA = propionic acidemia; MSUD = maple syrup urine disease; MCD = multiple carboxylase deficiency.</p

Health utility weight of IEM patients.

<p>PKU = phenylketonuria; IVA = isovaleric acidemia; MMA = methylmalonic acidemia; PA = propionic acidemia; MSUD = maple syrup urine disease; MCD = multiple carboxylase deficiency</p><p>Health utility weight of IEM patients.</p

One-way sensitivity analysis.

<p>Tornado graph showing results of one-way sensitivity analysis derived from probabilistic method. These figures indicating parameters which have the largest effect on incremental cost effectiveness ratio or ICER (THB per QALY gained) when they are varied individually. IPD = cost of inpatient care; OPD = cost of outpatient care.</p

Means and standard error (SE) of cost parameters presented in 2013 Thai Baht.

<p>^aCalculated at patient weight 1 kilogram.</p><p>NSCO = Neonatal Screening Operation Centre; PKU = phenylketonuria; IVA = isovaleric acidemia; MMA = methylmalonic acidemia; PA = propionic acidemia; MSUD = maple syrup urine disease; MCD = multiple carboxylase deficiency</p><p>1 I$ = 17.79 THB.</p

Budget Trend.

<p>The trend of the budget required for the screening programme compared with the current situation over ten years. THB = Thai baht.</p

Acceptability curve.

<p>The graph shows the probabilities of each strategy being cost-effective at a given ceiling ratio. The dashed lines represent the willingness to pay thresholds for the adoption of health interventions in Thailand.</p

Mean and standard error (SE) of transitional probabilities used in the model.

<p>^a See <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0134782#pone.0134782.s001" target="_blank">S1 Table</a> for death from other causes.</p><p>PKU = phenylketonuria; IVA = isovaleric acidemia; MMA = methylmalonic acidemia; PA = propionic acidemia; MSUD = maple syrup urine disease; MCD = multiple carboxylase deficiency; RR = Relative risk of early-diagnosed patients compared with clinical diagnosed patients</p><p>Mean and standard error (SE) of transitional probabilities used in the model.</p