21 research outputs found
834 Sequential regional hyperthermia (RH) and conformal radiotherapy (RT) in treating patients with locally advanced prostate cancer: Preliminary results in 96 patients
307 PSA DECLINING TIME (PSAHI) AS A PROGNOSTIC FACTOR IN METASTATIC HORMONE REFRACTORY PROSTATE CANCER (MHRPC) PATIENTS UNDERGOING DOCETAXEL (TAXOTERE) CHEMOTHERAPY
HORMONE REFRACTORY METASTATIC PROSTATE CANCER: DOES PSA HALVING TIME DURING DOCETAXEL TREATMENT HAVE A PROGNOSTIC ROLE?
Primari lymphoma of the kidney. Report of a case and update of the literature.
OBJECTIVES: To report on a case of primary renal lymphoma (PRL) and update the
literature concerning this topic.
MATERIALS AND METHODS: A 48-year-old woman underwent surgery for the presumed
diagnosis of renal cell carcinoma with bilateral adrenal metastases.
RESULTS: The neoplasm was assessed as primary renal non-Hodgkin high grade
lymphoma, diffuse large B-cell type. Then the patient underwent polychemotherapy
according to the VACOP-B protocol. Unfortunately, 5 weeks later the patient was
lost since missing chemotherapy and follow-up.
CONCLUSIONS: PRL is a distinct pathological and clinical entity which is
extremely rare and highly aggressive since disseminating rapidly from its origin.
The disease usually affects adults with an average age of 60 years and slight
male preponderance; however it has also been reported in childhood. Etiology
factors for PRL are unknown. Several histogenetic theories of the disease have
been postulated since the kidney does not normally contain lymphoid tissue.
Investigators reported many classes of non-Hodgkin lymphoma which include large,
small, intermediate and mixed cell types with high, intermediate or low grade
histologies. The neoplastic lymphoid cells may express both B and T immunoblastic
phenotypes, primary renal Hodgkin lymphoma has also been reported. The disease
may present with progressive renal failure of either oliguric or non oliguric
type. Imaging studies in diagnosing and staging primary renal lymphomas include
ultrasound examination (US) and computed tomography (CT); there are also some
reports of magnetic resonance imaging (MRI). Total body bone scan and bone marrow
biopsy will complete disease clinical staging. Renal biopsy is important in
assessing the diagnosis of PRL as well as of acute renal failure for bilateral
lymphomatous infiltration of the kidneys. Up to now, there are no standard
treatment modalities for this entity since the small number of cases reported.
Multidrug chemotherapy is mandatory for high grade lymphoma and when the disease
is diagnosed preoperatively. High dose chemotherapy in the future may offer a
curative approach in primary bilateral renal disease and without end-stage renal
disease. Survival is extremely poor since 75% of patients die less than 1 year
after operation. Prognosis may be improved by early detection of disease and by
performing systemic chemotherapy