Exploring the Direct Influence of the Organizational Change Process on Organizational Performance

Organizational change can significantly impact organizational performance, but this impact can be different depending on the nature and purpose of the change and how it is managed. The paper proposes a model for evaluating the effects of the organizational change process on organizational performance, staff retention, and organizational abandonment. The empirical study in which the model is tested was carried out among 294 employees from Romanian organizations who answered the questionnaire questions. Structural equation modeling was used to process the data and obtain the results. Effective change management and employee involvement in the change process can contribute to the success of organizational change and the development of a positive organizational culture, leading to increased organizational performance, high employee retention, and the organizational dropout rate minimization. In addition, organizations should also consider open and transparent communication with employees, as well as providing support in developing the skills and competencies of employees so that they can adapt to organizational changes and contribute to the organization's success

Cannabidiol, from Past to Present: a Review

The cannabis plant contains the naturally occurring substance cannabidiol, also known as CBD. As opposed to its more widely known relative, tetrahydrocannabinol (THC), cannabidiol (CBD), does not possess any psychoactive or euphoria-inducing properties, and is widely regarded as harmless and nonaddictive. Due to its alleged medicinal advantages, which are thought to include pain relief, anxiety reduction, epilepsy management and anti-inflammatory characteristics, CBD has attracted a lot of attention in recent years, in both human and veterinary medicine. The different kinds of CBD products available include oils, tinctures, capsules, lotions, and even edibles in the form of cookies and candy. In the field of veterinary medicine, the use of CBD has become more and more prevalent in recent years, and a formulation of treats for dogs and cats containing varying quantities of cannabidiol have been put on the market. Despite growing in popularity, CBD's legal status is still a little hazy in many nations, and more study is required to fully comprehend both its advantages and disadvantages. This article aims to review CBD’s history, mechanisms of action, potential therapeutic roles as well as adverse effects that have been encountered thus far in clinical studies

The Effects of Cannabidiol on Canine Epilepsy and Arthritis – a Case Study

Cannabidiol oil (CBD) has gained notoriety in recent years due to its effectiveness as an adjuvant therapy in many pathologies.The purpose of this study is to evaluate the effects of CBD in the management of pain and the associated pathologies of epilepsy and arthritis, on a single subject, a female Labrador, 12.5 years old at the beginning of the study. The therapeutic protocol used was the administration of CBD oil, sublingually, in doses of 2.25 mg/kg/day. Hematology and biochemistry were performed at 3, 6 and 12 months. Radiology was performed before the study began and after 6 months.After the first month, a decrease in the number and severity of epilepsy crises was observed. Beginning with the first 2 weeks of CBD oil administration, the patient was already experiencing an improvement in her mobility along with general pain remittance and the amelioration of her 3rd degree lameness, quantified by the Colorado Pain Scale. After 5 months of CBD administration, with no seizures recorded, phenytoin therapy was ceased. After 8 months, phenobarbital was also excluded from the therapeutic protocol, thus making CBD an independent the rapeutic molecule. CBD appears to be a useful molecule in managing both pain and epilepsy

The Study of Nutraceutical Effects of the Whey Zonar and of Lyophilized Concentrate Obtained from Zonar in C26 Colon Carcinoma Grafted Subcutaneously in Balb/C Mice

This paper investigates the nutraceutical properties of the whey Zonar and of lyophilized concentrate obtained from Zonar in C26 tumor bearing BALB/C mice. The experiment was conducted on 30 female mice, divided into 6 groups (n=5). Groups 4, 5 and 6 were injected subcutaneously with 1*106 C26 carcinoma cells. Groups 2,3, 5 and 6 received a diet based on Zonar products. The evolution of body mass and tumor volume was assessed weekly. At the end of the 21-day study, blood samples for hematological, biochemical and oxidative stress analysis were drawn and tumor tissue samples were collected for histopathological examination. After 21 days, a significant in vivo reduction of the tumor volume in groups 5 and 6 was recorded. The biochemical analysis showed Zonar's protective muscular effects, due to decreases of the creatine-kinase level in groups 5 and 6. Further investigations revealed an increased level of glutathione in all groups which received Zonar, eliciting its antioxidant potential. Histopathologically, increased necrotic areas highlighted the anti-tumoral effect of the synergism between Zonar and the lyophilized concentrate. The results of this experiment implies that whey Zonar & the lyophilized whey prevents tumor cachexia, as well as other cancer associated adverse effects

Nerve compression due to benign tumors or ganglion cysts in the upper limb – case series

Tumor nerve compressions in the upper limb are relatively rare, usually involving ganglion cysts and benign tumors. We present a case series of five patients with peripheral nerve compression in the upper limb due to tumor or cystic masses- ulnar nerve compression in the Guyon’s tunnel due to a ganglion cyst, large median nerve schwannoma compressing anterior interosseous nerve and median nerve, voluminous lipoma compressing median nerve in the proximal forearm, superficial branch of radial nerve compression by a synovial cyst and elbow region lipoma compressing radial nerve. In the beginning, those benign lesions are asymptomatic but, as they continue to grow adjacent to a peripheral nerve clinical manifestations appear progressively as compressive neuropathies. After a preoperative imagistic analysis, tumor resection with careful dissection, in order to preserve the neurovascular structures, is the elective surgical procedure in order to obtain an optimal functional recovery

2015/16 seasonal vaccine effectiveness against hospitalisation with influenza a(H1N1)pdm09 and B among elderly people in Europe: Results from the I-MOVE+ project

We conducted a multicentre test-negative caseâ\u80\u93control study in 27 hospitals of 11 European countries to measure 2015/16 influenza vaccine effectiveness (IVE) against hospitalised influenza A(H1N1)pdm09 and B among people aged â\u89¥ 65 years. Patients swabbed within 7 days after onset of symptoms compatible with severe acute respiratory infection were included. Information on demographics, vaccination and underlying conditions was collected. Using logistic regression, we measured IVE adjusted for potential confounders. We included 355 influenza A(H1N1)pdm09 cases, 110 influenza B cases, and 1,274 controls. Adjusted IVE against influenza A(H1N1)pdm09 was 42% (95% confidence interval (CI): 22 to 57). It was 59% (95% CI: 23 to 78), 48% (95% CI: 5 to 71), 43% (95% CI: 8 to 65) and 39% (95% CI: 7 to 60) in patients with diabetes mellitus, cancer, lung and heart disease, respectively. Adjusted IVE against influenza B was 52% (95% CI: 24 to 70). It was 62% (95% CI: 5 to 85), 60% (95% CI: 18 to 80) and 36% (95% CI: -23 to 67) in patients with diabetes mellitus, lung and heart disease, respectively. 2015/16 IVE estimates against hospitalised influenza in elderly people was moderate against influenza A(H1N1)pdm09 and B, including among those with diabetes mellitus, cancer, lung or heart diseases

Man feeling tired and “lousy” five days following myocardial infarction

A 70 year-old male presents to his cardiologist’s office with complaints of feeling fatigued and “lousy”. His past medical history is significant for HTN and HL, but until a recent hospitalization, he was non-compliant with his outpatient medical regimen. Of note, he also has a history of heavy alcohol consumption and a 30 pack-year smoking history. The patient reports that he was recently discharged after acute myocardial infarction (AMI) from an outside hospital. At that time, he underwent a diagnostic cardiac catheterization, but no intervention was performed secondary to 100% RCA stenosis and technical difficulties. He was sent home on clopidogrel, aspirin, metoprolol, lisinopril and simvastatin. He currently appears tired and anxious, however he has no symptoms of chest pain, dyspnea, orthopnea, diaphoresis, or lightheadedness; he does report that his primary symptoms leading him to admission was chest pain and shortness of breath

55 year old woman with pneumonia

A 55 year old Caucasian female smoker, with past medical history significant for hypertension and peptic ulcer disease presented to the emergency department with a four day complaint of malaise, fever, and myalgias. She was seen by her primary care physician who started her on amoxicillin clavulanate for possible strep throat infection. Her family reported a productive cough with green sputum, pleuritic chest pain, nausea, vomiting and diarrhea for one week. They also felt she was getting more confused over the past several hours