The cosmic snap parameter in f(R) gravity

We derive the expression for the snap parameter in f(R) gravity. We use the Palatini variational principle to obtain the field equations and regard the Einstein conformal frame as physical. We predict the present-day value of the snap parameter for the particular case f(R)=R-const/R, which is the simplest f(R) model explaining the current acceleration of the universe.Comment: 9 pages; published versio

Four-fermion interaction from torsion as dark energy

The observed small, positive cosmological constant may originate from a four-fermion interaction generated by the spin-torsion coupling in the Einstein-Cartan-Sciama-Kibble gravity if the fermions are condensing. In particular, such a condensation occurs for quark fields during the quark-gluon/hadron phase transition in the early Universe. We study how the torsion-induced four-fermion interaction is affected by adding two terms to the Dirac Lagrangian density: the parity-violating pseudoscalar density dual to the curvature tensor and a spinor-bilinear scalar density which measures the nonminimal coupling of fermions to torsion.Comment: 6 pages; published versio

Interacting dark energy in f(R)f(R) gravity

The field equations in $f(R)$ gravity derived from the Palatini variational principle and formulated in the Einstein conformal frame yield a cosmological term which varies with time. Moreover, they break the conservation of the energy--momentum tensor for matter, generating the interaction between matter and dark energy. Unlike phenomenological models of interacting dark energy, $f(R)$ gravity derives such an interaction from a covariant Lagrangian which is a function of a relativistically invariant quantity (the curvature scalar $R$). We derive the expressions for the quantities describing this interaction in terms of an arbitrary function $f(R)$, and examine how the simplest phenomenological models of a variable cosmological constant are related to $f(R)$ gravity. Particularly, we show that $\Lambda c^2=H^2(1-2q)$ for a flat, homogeneous and isotropic, pressureless universe. For the Lagrangian of form $R-1/R$, which is the simplest way of introducing current cosmic acceleration in $f(R)$ gravity, the predicted matter--dark energy interaction rate changes significantly in time, and its current value is relatively weak (on the order of 1% of $H_0$), in agreement with astronomical observations.Comment: 8 pages; published versio

A novel method for gene-specific enhancement of protein translation by targeting 5’UTRs of selected tumor suppressors

Background Translational control is a mechanism of protein synthesis regulation emerging as an important target for new therapeutics. Naturally occurring microRNAs and synthetic small inhibitory RNAs (siRNAs) are the most recognized regulatory molecules acting via RNA interference. Surprisingly, recent studies have shown that interfering RNAs may also activate gene transcription via the newly discovered phenomenon of small RNA-induced gene activation (RNAa). Thus far, the small activating RNAs (saRNAs) have only been demonstrated as promoter-specific transcriptional activators. Findings We demonstrate that oligonucleotide-based trans-acting factors can also specifically enhance gene expression at the level of protein translation by acting at sequence-specific targets within the messenger RNA 5’-untranslated region (5’UTR). We designed a set of short synthetic oligonucleotides (dGoligos), specifically targeting alternatively spliced 5’UTRs in transcripts expressed from the THRB and CDKN2A suppressor genes. The in vitro translation efficiency of reporter constructs containing alternative TRβ1 5’UTRs was increased by up to more than 55-fold following exposure to specific dGoligos. Moreover, we found that the most folded 5’UTR has higher translational regulatory potential when compared to the weakly folded TRβ1 variant. This suggests such a strategy may be especially applied to enhance translation from relatively inactive transcripts containing long 5’UTRs of complex structure. Significance This report represents the first method for gene-specific translation enhancement using selective trans-acting factors designed to target specific 5’UTR cis-acting elements. This simple strategy may be developed further to complement other available methods for gene expression regulation including gene silencing. The dGoligo-mediated translation-enhancing approach has the potential to be transferred to increase the translation efficiency of any suitable target gene and may have future application in gene therapy strategies to enhance expression of proteins including tumor suppressors

The present universe in the Einstein frame, metric-affine R+1/R gravity

We study the present, flat isotropic universe in 1/R-modified gravity. We use the Palatini (metric-affine) variational principle and the Einstein (metric-compatible connected) conformal frame. We show that the energy density scaling deviates from the usual scaling for nonrelativistic matter, and the largest deviation occurs in the present epoch. We find that the current deceleration parameter derived from the apparent matter density parameter is consistent with observations. There is also a small overlap between the predicted and observed values for the redshift derivative of the deceleration parameter. The predicted redshift of the deceleration-to-acceleration transition agrees with that in the \Lambda-CDM model but it is larger than the value estimated from SNIa observations.Comment: 11 pages; published versio

Torsion, an alternative to dark matter?

We confront Einstein-Cartan's theory with the Hubble diagram. An affirmative answer to the question in the title is compatible with today's supernovae data.Comment: 14 pp, 3 figures. Version 2 matches the version published in Gen. Rel. Grav., references added. Version 3 corrects a factor 3 in Cartan's equations to become

Big bounce from spin and torsion

The Einstein-Cartan-Sciama-Kibble theory of gravity naturally extends general relativity to account for the intrinsic spin of matter. Spacetime torsion, generated by spin of Dirac fields, induces gravitational repulsion in fermionic matter at extremely high densities and prevents the formation of singularities. Accordingly, the big bang is replaced by a bounce that occurred when the energy density $\epsilon\propto gT^4$ was on the order of $n^2/m_\textrm{Pl}^2$ (in natural units), where $n\propto gT^3$ is the fermion number density and $g$ is the number of thermal degrees of freedom. If the early Universe contained only the known standard-model particles ($g\approx 100$), then the energy density at the big bounce was about 15 times larger than the Planck energy. The minimum scale factor of the Universe (at the bounce) was about $10^{32}$ times smaller than its present value, giving \approx 50 \mum. If more fermions existed in the early Universe, then the spin-torsion coupling causes a bounce at a lower energy and larger scale factor. Recent observations of high-energy photons from gamma-ray bursts indicate that spacetime may behave classically even at scales below the Planck length, supporting the classical spin-torsion mechanism of the big bounce. Such a classical bounce prevents the matter in the contracting Universe from reaching the conditions at which a quantum bounce could possibly occur.Comment: 6 pages; published versio

Acceleration of the universe in the Einstein frame of a metric-affine f(R) gravity

We show that inflation and current cosmic acceleration can be generated by a metric-affine f(R) gravity formulated in the Einstein conformal frame, if the gravitational Lagrangian L(R) contains both positive and negative powers of the curvature scalar R. In this frame, we give the equations for the expansion of the homogeneous and isotropic matter-dominated universe in the case L(R)=R+{R^3}/{\beta^2}-{\alpha^2}/{3R}, where \alpha and \beta are constants. We also show that gravitational effects of matter in such a universe at very late stages of its expansion are weakened by a factor that tends to 3/4, and the energy density of matter \epsilon scales the same way as in the \Lambda-CDM model only when \kappa*\epsilon<<\alpha.Comment: 12 pages; published versio

Measurements, Models, Systems and Design

531 s.

On the nonsymmetric purely affine gravity

We review the vacuum purely affine gravity with the nonsymmetric connection and metric. We also examine dynamical effects of the second Ricci tensor and covariant second-rank tensors constructed from the torsion tensor in the gravitational Lagrangian.Comment: 15 pages; published versio