Stigmatisation and self-stigmatisation of patients with mental disorders committed suicide attempts

This study aims to determine clinical characteristics of stigmatisation and self-stigmatisation of patients who committed suicide attempts on the basis of "mental illness" and "suicide

Physical restraint in the provision of medical care in somatic hospital: ethics and law

The ethics and legality of the use of physical restraint (PR) in the case of patients with acute mental disorders in general practice are discusse

Genes involved in the regulation of vascular homeostasis determine renal survival rate in patients with chronic glomerulonephritis

In this study, we analyzed association of genes of vascular homeostasis with hypertension and renal survival of CGN patients. The study sample included 238 patients with CGN and 304 healthy subjects of population control. Ten polymorphisms of ten genes of vascular homeostasis were genotyped through polymerase chain reaction (PCR), restriction fragment length polymorphism (RFLP) analysis and TaqMan assays. Association of the genotypes with renal survival was analyzed by the Kaplan-Meier estimato

Genes of tumor necrosis factors and their receptors and the primary open angle glaucoma in the population of Central Russia

To examine the association of genetic polymorphisms (-308)G/A TNFα, (+250)A/G Ltα, (+36)A/G TNFR1, (+1663) A/G TNFR2 with the development of primary open angle glaucoma (POAG) among people in Central Russi

Bioinformatic Analysis of the Liability to the Hyperplastic Processes of the Uterus

This paper presents the results of bioinformatic analysis of five molecular genetic markers of 947 women with uterine hyperplasia and 988 women of the control grou

Altered erythrocyte membrane protein composition mirrors pleiotropic effects of hypertension susceptibility genes and disease pathogenesis

The study was designed to assess the effects of polymorphisms in genes associated with essential hypertension on the variation of erythrocyte membrane proteins (EMPs) in hypertensive patientsyesBelgorod State National Research Universit

Joint effect of glutathione S-transferase genotypes and cigarette smoking on idiopathic male infertility

Inconsistent results of association studies investigated the role of glutathione S-transferase genes in idiopathic male infertility may be explained by ethnical differences in gene-gene and gene-environment interactions. In this study, we investigated a joint contribution of GSTM1, GSTT1 and GSTP1 gene polymorphisms and cigarette smoking to the risk of idiopathic infertility in Russian menyesBelgorod State National Research Universit

A comprehensive contribution of genes for aryl hydrocarbon receptor signaling pathway to hypertension susceptibility

The present study was designed to investigate whether genetic polymorphisms of the aryl hydrocarbon receptor (AHR) signaling pathway are involved in the molecular basis of essential hypertension (EH

Synergism between the N-acetyltransferase 2 gene and oxidant exposure increases the risk of idiopathic male infertility

N-acetyltransferase (NAT2) is a phase-II xenobiotic-metabolizing enzyme participating in the detoxification of toxic arylamines, aromatic amines and hydrazines. The present study was designed to investigate whether two common single-nucleotide polymorphisms (SNP) of the NAT2 gene (481C>T, rs1799929; 590G>A, rs1799930) are associated with susceptibility to idiopathic male infertility and to assess if the risk is modified by oxidant and antioxidant exposures. A total 430 DNA samples (203 infertile patients and 227 fertile men) were genotyped for the polymorphisms by PCR and restriction fragment length polymorphism. No association was found between the NAT2 polymorphisms and idiopathic male infertilit

Genetic determinants of endometriosis and uterine myoma combinatin

The objective of the research was a bioinformatic study of the involvement of candidate genes in the formation of a combination of endometriosis with uterine myoma in wome