Dataset Body weight variation is not an independent factor in the determination of functional hypothalamic amenorrhea in Anorexia Nervosa

Dataset of the paper Body weight variation is not an independent factor in the determination of functional hypothalamic amenorrhea in Anorexia Nervos

From avatars to body swapping: The use of virtual reality for assessing and treating body-size distortion in individuals with anorexia

In the last 30 years, virtual reality (VR) has offered innovative solutions for assessing and treating body representation disturbances in anorexia nervosa (AN). The most recent and innovative trend is the exploitation of the so-called VR-based body swapping illusion. The aim of this case study was to report the use of this VR protocol within a multidisciplinary treatment of AN. A patient with a Diagnostic and Statistical Manual-5 diagnosis of AN underwent an intensive multidisciplinary outpatient treatment. Three sessions of a VR-based body swapping illusion (i.e., the experimental induction of being the owner of a virtual body as a result of a visuotactile stimulation) were delivered within the treatment protocol (i.e., beginning of the treatment; end of one cycle of the treatment; 1 year of follow-up). We report the results obtained, discussing how the VR full body illusion was both able to effectively monitor changes of multisensory bodily integration and to act as a driver for these changes

Interoceptive axes dissociation in Anorexia nervosa: A single case study with Follow Up Post-Recovery assessment

Anorexia nervosa (AN) is a disorder characterized by alterations in body perception. Recent literature suggested that AN can also impair the processing of stimuli from inside the body (i.e., interoceptive) however, very few studies performed a complete interoceptive assessment exploring the evolution of the interoceptive dimensions before and after the subject's recovery. To address this gap in knowledge, this study presented the case of Diana, a 25 years old woman affected by AN. At hospital admission, Diana performed a complete interoceptive assessment for accuracy (IAc), metacognitive awareness (IAw), sensibility (IAs), and interoceptive buffer saturation (IBs) - a new index that behaviourally evaluated the amount of interoceptive processing. Measures were repeated at the end of an outpatients rehabilitative hospital program, after Diana's recovery. Results were confronted with a control (N = 4) of healthy female subjects. Analyses indicated severe deficits in accuracy, buffer saturation, and sensibility compared to control group. Conversely, metacognitive awareness was pathologically enhanced. After the rehabilitative hospital program, Diana's clinical condition was largely improved and this reflected back on the interoceptive patterns that appeared restored, with no difference in interoceptive accuracy and metacognition compared to the control group. In conclusion, results indicated a very specific dissociation between interoceptive axes in AN with pervasive deficits in perception and processing that were accompanied by a pathologically enhanced confidence in the wrong perceptions. This case study reported an interesting and unique clinical pattern with a severe dissociation between interoceptive perceptions that nonetheless appeared restored after the subject's recovery, highlighting the role of interoceptive assessment in the clinical evolution of AN

User Experience and usability of a new virtual reality set-up to treat eating disorders: a pilot study

Virtual Reality (VR) has progressively emerged as an effective tool for wellbeing and health in clinical populations. VR effectiveness has been tested before in Anorexia Nervosa (AN) with full-body illusion. It consists in the embodiment of patients with AN into a different virtual body to modify their long-term memory of the body as a crucial factor for the onset and maintenance of this disorder. We extended this protocol using the autobiographical recall emotion-induction technique, in which patients recall an emotional episode of their life related to their body. In this pilot study, we aimed to test the usability and User Experience (UX) of this VR-based protocol. Five Italian women with AN were embodied in a virtual body resembling their perceived body size from an ego- and an allocentric perspective while remembering episodes of their life related to their body. High levels of embodiment were reported while embodied in a virtual body resembling their real perceived body size for ownership (p<0.0001), agency (p=0.04), and self-location (p=0.023). Negative affective state increase after session 2 (p=0.012), and positive affective state increase after session 4 (p=0.006) (PANAS). However, further iteration of the VR system is needed to improve the user experience and usability of the system

Two-phases innovative treatment for anorexia nervosa: The potential of virtual reality body-swap

It is known that experiencing body as one’s own depend on the integration of different bodily signals (i.e., proprioceptive, tactile, visual, vestibular inputs). In the current study, a group of female participants suffering from Anorexia Nervosa (N=23) viewed within a first-person perspective a virtual body with a skinny belly substituting their own physical body in two experimental conditions (i.e., synchronous vs. asynchronous visual-tactile stimulation). This allowed us to investigate whether illusionary ownership over a virtual body would result in differences in body representation (as measured by asking participants to estimate their body size) before and after a multidisciplinary treatment provided in a center of excellence. Before treatment, there was a significant distortion in body representation, especially as concerns the estimation of the circumference of the abdomen and the hips. After the treatment, the most interesting result is a decrease in the body-size distortions in abdomen. This innovative approach, if further investigated, may be useful for anorectic patients for specifically improving body representation disturbances

Fonni’s dog: morphological and genetic characteristics for a breed standard definition

Italy is home to several populations of native dogs that reside only in certain demographic regions. Such dog populations have not been under tight selection by humans and, as such, have never been officially recognised as breeds. One such population is the ‘Cane Fonnese’ or Fonni’s Dog, which features uniform morphologic and behavioural traits that reproduce across generations, thus qualifying Fonni’s Dog as a true breed eligible for recognition by national or international breed registries. The Fonni’s Dog population examined in the present work is native to Sardinia, where they are used as property or livestock guardian dogs. As such, they are greatly appreciated by the local populace. We have carried out morphological evaluations on 200 Fonni’s Dogs with the aim of developing a standard breed definition upon which the foundation of the Fonni’s Dog breed can be based. We have also reported genetic data of the Fonni’s Dog compared to four other established breeds sampled from the same geographic area

Exemestane is superior to megestrol acetate after tamoxifen failure in postmenopausal women with advanced breast cancer: results of a phase III randomized double-blind trial

PURPOSE: This phase III, double-blind, randomized, multicenter study evaluated the efficacy, pharmacodynamics, and safety of the oral aromatase inactivator exemestane (EXE) versus megestrol acetate (MA) in postmenopausal women with progressive advanced breast cancer who experienced failure of tamoxifen. PATIENTS AND METHODS: A total of 769 patients were randomized to EXE 25 mg/d (n = 366) or MA (n = 403) 40 mg four times daily. Tumor response, duration of tumor control, tumor-related signs and symptoms (TRSS), quality of life (QOL), survival, and tolerability were evaluated. RESULTS: Overall objective response (OR) rates were higher in patients treated with EXE than in those treated with MA (15.0% v 12.4%); a similar trend was noted in patients with visceral metastases (13.5% v 10.5%). Median survival time was significantly longer with EXE (median not reached) than with MA (123.4 weeks; P = .039), as were the median duration of overall success (OR or stable disease ≥ 24 weeks; 60.1 v 49.1 weeks; P = .025), time to tumor progression (20.3 v 16.6 weeks; P = .037), and time to treatment failure (16.3 v 15.7 weeks; P = .042). Compared with MA, there were similar or greater improvements in pain, TRSS, and QOL with EXE. Both drugs were well tolerated. Grade 3 or 4 weight changes were more common with MA (17.1% v 7.6%; P = .001). CONCLUSION: EXE prolongs survival time, time to tumor progression, and time to treatment failure compared with MA and offers a well-tolerated treatment option for postmenopausal women with progressive advanced breast cancer who experienced failure of tamoxifen. </jats:p