Can Cleveland Clinic Health System Be Trusted: Whether a Proposed Merger or Acquisition by Cleveland Clinic Health System Will Substantially Impair the Competitive Health Care Market in Northeast Ohio Resulting in a Violation of Federal Antitrust Statutes

This article analyzes the implications of the Clayton Antitrust Act (Clayton Act) and the Sherman Antitrust Act (Sherman Act) as they pertain to the Cleveland Clinic Health System (CCHS). Part One provides background analysis of these two statutes, and the application of those statutes to mergers in the health care industry. Part Two discusses the elements needed to prove the government\u27s prima facie case. This consists of a discussion of a relevant market, which includes the product and geographic markets. This section also contains a description and analysis of market concentration, measured by the Herfindahl-HIrschman Index (HHI). Part Three provides further background information on the CCHS hospital affiliates, and discusses CCHS\u27s recent acquisition activities. Part Four analyzes whether these recent activities amount to a violation of antitrust laws, warranting further investigation by the FTC. This section also provides a description and analysis of two possible defenses that CCHS may raise

A New Derivation of the CPT and Spin-Statistics Theorems in Non-Commutative Field Theories

We propose an alternative axiomatic description for non-commutative field theories (NCFT) based on some ideas by Soloviev to nonlocal quantum fields. The local commutativity axiom is replaced by the weaker condition that the fields commute at sufficiently large spatial separations, called asymptotic commutativity, formulated in terms of the theory of analytic functionals. The question of a possible violation of the CPT and Spin-Statistics theorems caused by nonlocality of the commutation relations $[\hat{x}_\mu,\hat{x}_\nu]=i\theta_{\mu\nu}$ is investigated. In spite of this inherent nonlocality, we show that the modification aforementioned is sufficient to ensure the validity of these theorems for NCFT. We restrict ourselves to the simplest model of a scalar field in the case of only space-space non-commutativity.Comment: The title is new, and the analysis in the manuscript has been made more precise. This revised version is to be published in J.Math.Phy

Early Response to the Plant Toxin Stenodactylin in Acute Myeloid Leukemia Cells Involves Inflammatory and Apoptotic Signaling

Stenodactylin, a highly toxic type 2 ribosome-inactivating protein purified from the caudex of Adenia stenodactyla Harms, is a potential anticancer drug candidate. Previous studies demonstrated that stenodactylin induces apoptosis and necroptosis in treated cells, involving the production of reactive oxygen species. We analyzed the effect of stenodactylin on Raji and Ramos (Human Burkitt’s lymphoma cells) and MOLM-13 (acute myeloid leukemia cells). Moreover, we focused on the early events in MOLM-13 cells that characterize the cellular response to the toxin by whole-genome microarray analysis of gene expression. Treatment with stenodactylin induced the depurination of 28S rRNA within 4 h and increased the phosphorylation of p38 and JNK. A time-dependent activation of caspase 1, 2, 8, 9, 3/7 was also observed. Genome-wide gene expression microarray analysis revealed early changes in the expression of genes involved in the regulation of cell death, inflammation and stress response. After 4 h, a significant increase of transcript level was detectable for ATF3, BTG2, DUSP1, EGR1, and JUN. Increased upstream JUN signaling was also confirmed at protein level. The early response to stenodactylin treatment involves inflammatory and apoptotic signaling compatible with the activation of multiple cell death pathways. Because of the above described properties toward acute myeloid leukemia cells, stenodactylin may be a promising candidate for the design of new immunoconjugates for experimental cancer treatment

Stable isotope analyses of feather amino acids identify penguin migration strategies at ocean basin scales

Author Posting. © The Author(s), 2017. This is the author's version of the work. It is posted here under a nonexclusive, irrevocable, paid-up, worldwide license granted to WHOI. It is made available for personal use, not for redistribution. The definitive version was published in Biology Letters 13 (2017): 20170241, doi:10.1098/rsbl.2017.0241.Identifying the at-sea distribution of wide ranging 20 marine predators is critical to understanding their ecology. Advances in electronic tracking devices and intrinsic biogeochemical markers have greatly improved our ability to track animal movements on ocean-wide scales. Here we show that, in combination with direct tracking, stable carbon isotope analysis of essential amino acids in tail feathers provides the ability to track the movement patterns of two, wide-ranging penguin species over ocean basin scales. In addition, we use this isotopic approach across multiple breeding colonies in the Scotia Arc to evaluate migration trends at a regional scale that would be logistically challenging using direct tracking alone.Funded by the National Marine Sanctuary Foundation (GLS tags), Ocean Life Institute (M.J.P, L.H., S.R.T), Darwin Initiative (T.H.), and SeaWorld Bush Gardens Conservation Fund (M.J.P, S.R.T)

Stable isotope analyses of feather amino acids identify penguin migration strategies at ocean basin scales

Identifying the at-sea distribution of wide-ranging marine predators is critical to understanding their ecology. Advances in electronic tracking devices and intrinsic biogeochemical markers have greatly improved our ability to track animal movements on ocean-wide scales. Here, we show that, in combination with direct tracking, stable carbon isotope analysis of essential amino acids in tail feathers provides the ability to track the movement patterns of two, wide-ranging penguin species over ocean basin scales. In addition, we use this isotopic approach across multiple breeding colonies in the Scotia Arc to evaluate migration trends at a regional scale that would be logistically challenging using direct tracking alone.Facultad de Ciencias Naturales y Muse

Towards a Universal Method for the Stable and Clean Functionalization of Inert Perfluoropolymer Nanoparticles : Exploiting Photopolymerizable Amphiphilic Diacetylenes

Highly fluorinated materials are being widely investigated due to a number of peculiar properties, which are potentially useful for various applications, including use as lubricants, anti-adhesive films, and substitutes for biological fluids for biomedical utilization. However, at present such potential is still poorly exploited. One of the major drawbacks that hampers the rapid development of nanoscale fluoro-hybrid devices is the remarkable inertness of perfluoropolymeric materials that lack reactive functionalities, as they do not offer any functional groups that can be employed to covalently anchor organic molecules on their surface. In this paper, a convenient method for the stable biofunctionalization of strongly unreactive perfluoropolymer nanoparticles (PnPs) is reported. PnPs are easily coated with newly synthesized asymmetric diacetylenic monomer compounds (ADMs), thanks to PnP's high propensity to interact with hydrophobic moieties. Once monomerically adsorbed onto PnPs, such suitably designed ADMs enable the formation of a robust polymeric shell around the perfluoroelastomer core via a clean UV-promoted localized photopolymerization. Given the peculiar optical characteristics of PnPs, the coating of the particles can be monitored step by step using light scattering, which also allows estimation of the fraction of reacted monomers by competitive adsorption with smaller particles. The potential of this method for the biofunctionalization of PnPs is demonstrated with representative proteins and carbohydrates. Among them, the extension to avidin-biotin technology may broaden the scope and applicability of this strategy to potentially a large number of molecules of biomedical interest. Making the unreactive reactive: A smart method for the biofunctionalization of strongly inert perfluoropolymer nanoparticles (PnPs) is presented, using a stable coating with novel diacetylenic compounds followed by clean UV photopolymerization to generate reactive functionalities on the PnP surface. This method further allows fine tuning of the amount of conjugated biomolecules, which can be sensitively and straightforwardly quantified

Supersymmetric Field-Theoretic Models on a Supermanifold

We propose the extension of some structural aspects that have successfully been applied in the development of the theory of quantum fields propagating on a general spacetime manifold so as to include superfield models on a supermanifold. We only deal with the limited class of supermanifolds which admit the existence of a smooth body manifold structure. Our considerations are based on the Catenacci-Reina-Teofillatto-Bryant approach to supermanifolds. In particular, we show that the class of supermanifolds constructed by Bonora-Pasti-Tonin satisfies the criterions which guarantee that a supermanifold admits a Hausdorff body manifold. This construction is the closest to the physicist's intuitive view of superspace as a manifold with some anticommuting coordinates, where the odd sector is topologically trivial. The paper also contains a new construction of superdistributions and useful results on the wavefront set of such objects. Moreover, a generalization of the spectral condition is formulated using the notion of the wavefront set of superdistributions, which is equivalent to the requirement that all of the component fields satisfy, on the body manifold, a microlocal spectral condition proposed by Brunetti-Fredenhagen-K\"ohler.Comment: Final version to appear in J.Math.Phy

Spatial and isotopic niche partitioning during winter in chinstrap and Adélie penguins from the South Shetland Islands

© The Author(s), 2015. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Ecosphere 6 (2015): art125, doi:10.1890/ES14-00287.1.Closely related species with similar ecological requirements should exhibit segregation along spatial, temporal, or trophic niche axes to limit the degree of competitive overlap. For migratory marine organisms like seabirds, assessing such overlap during the non-breeding period is difficult because of long-distance dispersal to potentially diffuse foraging habitats. Miniaturization of geolocation devices and advances in stable isotope analysis (SIA), however, provide a robust toolset to quantitatively track the movements and foraging niches of wide ranging marine animals throughout much of their annual cycle. We used light-based geolocation tags and analyzed stable carbon and nitrogen isotopes from tail feathers to simultaneously characterize winter movements, habitat utilization, and overlap of spatial and isotopic niches of migratory chinstrap (Pygoscelis antarctica) and Adélie (P. adeliae) penguins during the austral winter of 2012. Chinstrap penguins exhibited a higher diversity of movements and occupied portions of the Southern Ocean from 138° W to 30° W within a narrow latitudinal band centered on 60° S. In contrast, all tracked Adélie penguins exhibited smaller-scale movements into the Weddell Sea and then generally along a counter-clockwise path as winter advanced. Inter-specific overlap during the non-breeding season was low except during the months immediately adjacent to the summer breeding season. Intra-specific overlap by chinstraps from adjacent breeding colonies was higher throughout the winter. Spatial segregation appears to be the primary mechanism to maintain inter- and intra-specific niche separation during the non-breeding season for chinstrap and Adélie penguins. Despite low spatial overlap, however, the data do suggest that a narrow pelagic corridor in the southern Scotia Sea hosted both chinstrap and Adélie penguins for most months of the year. Shared occupancy and similar isotopic signatures of the penguins in that region suggests that the potential for inter-specific competition persists during the winter months. Finally, we note that SIA was able to discriminate eastward versus westward migrations in penguins, suggesting that SIA of tail feathers may provide useful information on population-level distribution patterns for future studies.Funds for the GLS tags were provided by the National Marine Sanctuary Foundation. Additional support for this project was provided by a Woods Hole Oceanographic Devonshire Scholarship as well as funding from the Ocean Life Institute and SeaWorld Bush Gardens Conservation Fund to MJP