Chaotic masking of information signals using generator based on the Liu system

Lyapunov exponent spectrum for a chaotic Liu system was calculated in this work. The possibility to set the synchronization between generators based on the system under investigation was shown. A communication system was experimentally realized using chaotic generators

A Study of Synchronization Processes of Nonlinear Systems in the Difference Space of Phase Variables

The analysis of trajectories in the phase space of the systems of ordinary differential equations has been made. Classification of phase trajectories has been developed.Synchronization in Rössler systems, coupled by the scheme “main–controlled” system, has been studied. In the controlled system, variables in the right –hand side are replaced by functions of time, which are solutions to the main system.The analysis of processes in nonlinear systems was made by means of replacement with the help of synchronization matrix and transfer to the linearized system of variables equal to the difference of phase variables of the main and controlled systems. As a result of this analysis, there have been set the values of the synchronization matrix elements in which there occur different types of synchronization: complete, phase and topological. It is shown that even in the absence of communication between Rössler systems in the difference space of phase variables of the main and controlled systems with nonlinear dynamics, there occurs topological synchronization and there is formed an attractor with low spatial complexity that is an open trajectory of limited values. The criterion for the absence of synchronization of nonlinear systems is the unlimited growth of the difference of phase variable

СУБМІКРОННІ ТА НАНОРОЗМІРНІ СТРУКТУРИ ЕЛЕКТРОНІКИ

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Comparative effectiveness and safety of anticoagulants for the treatment of heparin‐induced thrombocytopenia

BACKGROUND The effectiveness and safety of non-heparin anticoagulants for the treatment of heparin-induced thrombocytopenia (HIT) are not fully established, and the optimal treatment strategy is unknown. In a systematic review and meta-analysis, we aimed to determine precise rates of platelet recovery, new or progressive thromboembolism (TE), major bleeding, and death for all non-heparin anticoagulants and to study potential sources of variability. METHODS Following a detailed protocol (PROSPERO: CRD42020219027), EMBASE and Medline were searched for all studies reporting clinical outcomes of patients treated with non-heparin anticoagulants (argatroban, danaparoid, fondaparinux, direct oral anticoagulants [DOAC], bivalirudin, and other hirudins) for acute HIT. Proportions of patients with the outcomes of interest were pooled using a random-effects model for each drug. The influence of the patient population, the diagnostic test used, the study design, and the type of article was assessed. RESULTS Out of 3194 articles screened, 92 studies with 119 treatment groups describing 4698 patients were included. The pooled rates of platelet recovery ranged from 74% (bivalirudin) to 99% (fondaparinux), TE from 1% (fondaparinux) to 7% (danaparoid), major bleeding from 1% (DOAC) to 14% (bivalirudin), and death from 7% (fondaparinux) to 19% (bivalirudin). Confidence intervals were mostly overlapping, and results were not influenced by patient population, diagnostic test used, study design, or type of article. DISCUSSION Effectiveness and safety outcomes were similar among various anticoagulants, and significant factors affecting these outcomes were not identified. These findings support fondaparinux and DOACs as viable alternatives to conventional anticoagulants for treatment of acute HIT in clinical practice