Three- to five-minute motivational counseling reduces perceived stress in adults with acute myocardial infarction: a pilot study

Introducción. A pesar de la evidencia creciente del impacto del estrés sobre lasalud cardiovascular, la traducción de este conocimiento en prácticas clínicasefectivas es limitada. El objetivo de este estudio es determinar la efectividad deuna intervención motivacional sobre el estrés percibido de adultos internadospor infarto agudo de miocardio (IAM).Métodos. Se incluyeron a pacientes internados por IAM, con estrés autorreferido,aleatorizados a una intervención motivacional breve o a tratamiento estándar.La intervención se realizó durante la hospitalización índice y por consultoriosexternos. La escala de estrés percibido (PSS) fue utilizada para evaluar elestrés de los pacientes en el mes previo.Resultados. Se incluyeron a 22 pacientes, en su mayoría hombres (77,3%) demediana edad (55 [49-80] años). El cambio en la puntuación mediana de la PSSentre la hospitalización índice y el mes posterior al egreso hospitalario fue signicativamente diferente en los pacientes aleatorizados al grupo intervenciónrespecto al grupo control (–11 vs 3 puntos; p=0,0001). La intervención se asociócon una reducción signicativa en la puntuación mediana de la PSS, luegode ajustar por género y edad (β=–13,3; p<0,001).Conclusiones. Una intervención motivacional breve en adultos internados porIAM podría reducir el estrés percibido.Introduction. Though there is growing evidence of the impact of stress on cardiovascular health, the translation of this knowledge into effective clinical practice is limited. The goal of this study is to determine the effectiveness of a motivational intervention on the perceived stress of adults admitted for acute myocardial infarction (AMI). Methods: Patients admitted for AMI, with self-reported stress, were included and randomized to a brief motivational intervention or to standard treatment. The intervention was performed during the index admission and during outpatient follow-up. The perceived stress scale (PSS) was used to evaluate patients’ stress in the previous month. Results: This study included 22 patients, mostly middle-aged (55 [49-80] yearold) men (77.3%). The change in the median PSS score between the index admission and the month after discharge was signi cantly different between patients randomized to the intervention group and to the control group (–11 vs 3 points; p=0.0001). The intervention was also signi canty associated with a reduction in the median score of the PSS, after adjusting for gender and age (β=– 13.3; p<0.001). Conclusions:A brief motivational intervention in adults admitted for AMI could reduce perceived stress.Fil: Tartaglione, Fiorella. Sanatorio de la Trinidad Mitre; ArgentinaFil: Politi, Teresa. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; ArgentinaFil: Polit, Raúl. Sanatorio de la Trinidad Mitre; ArgentinaFil: Bortman, Guillermo. Sanatorio de la Trinidad Mitre; Argentin

A preclinical mice model of multiple sclerosis based on the toxin-induced double-site demyelination of callosal and cerebellar fibers

Abstract Background Multiple sclerosis (MS) is an irreversible progressive CNS pathology characterized by the loss of myelin (i.e. demyelination). The lack of myelin is followed by a progressive neurodegeneration triggering symptoms as diverse as fatigue, motor, locomotor and sensory impairments and/or bladder, cardiac and respiratory dysfunction. Even though there are more than fourteen approved treatments for reducing MS progression, there are still no cure for the disease. Thus, MS research is a very active field and therefore we count with different experimental animal models for studying mechanisms of demyelination and myelin repair, however, we still lack a preclinical MS model assembling demyelination mechanisms with relevant clinical-like signs. Results Here, by inducing the simultaneous demyelination of both callosal and cerebellar white matter fibers by the double-site injection of lysolecithin (LPC), we were able to reproduce CNS demyelination, astrocyte recruitment and increases levels of proinflammatory cytokines levels along with motor, locomotor and urinary impairment, as well as cardiac and respiratory dysfunction, in the same animal model. Single site LPC-injections either in corpus callosum or cerebellum only, fails in to reproduce such a complete range of MS-like signs. Conclusion We here report that the double-site LPC injections treatment evoke a complex MS-like mice model. We hope that this experimental approach will help to deepen our knowledge about the mechanisms of demyelinated diseases such as MS