On the effectiveness of the activities of russian universities in the field of research and education export under sanctions

The article studies statistical data in the field of education export and research activities of Russian universities subordinate to the Ministry of Science and Higher Education of the Russian Federation (hereinafter – the Ministry of Education and Science of Russia) and examines the impact of sanctions of “unfriendly countries” on the educational export programs effectiveness in Russian universities and effectiveness of research activities of organizations subordinate to the Ministry. In 2022 a hypothesis has been put forward that there is no significant impact of the sanctions of “unfriendly countries” on the effectiveness of research activities and educational export programs in Russian universities (in the short term), provided that the existing mechanisms of university science state management are functioning. New data collected in 2023 based on the analysis results of the reports of universities subordinate to the Ministry of Education and Science of Russia made it possible to verify the Hypothesis. As a study result, it was shown that, subject to the functioning of the existing mechanisms of the higher education system state regulation, the scientific and educational activities of Russian universities in the field of international cooperation are not only little vulnerable to sanctions from “unfriendly countries”, but also have the potential for development. The authors emphasize that the effectiveness of educational activities of Russian universities subordinated to the Ministry of Education and Science of Russia in the field of international cooperation is higher than scientific and technical

The optical identifcation of events with poorly defined locations: The case of the Fermi GBM GRB140801A

We report the early discovery of the optical afterglow of gamma-ray burst (GRB) 140801A in the 137 deg$^2$ 3-$\sigma$ error-box of the Fermi Gamma-ray Burst Monitor (GBM). MASTER is the only observatory that automatically react to all Fermi alerts. GRB 140801A is one of the few GRBs whose optical counterpart was discovered solely from its GBM localization. The optical afterglow of GRB 140801A was found by MASTER Global Robotic Net 53 sec after receiving the alert, making it the fastest optical detection of a GRB from a GBM error-box. Spectroscopy obtained with the 10.4-m Gran Telescopio Canarias and the 6-m BTA of SAO RAS reveals a redshift of $z=1.32$. We performed optical and near-infrared photometry of GRB 140801A using different telescopes with apertures ranging from 0.4-m to 10.4-m. GRB 140801A is a typical burst in many ways. The rest-frame bolometric isotropic energy release and peak energy of the burst is $E_\mathrm{iso} = 5.54_{-0.24}^{+0.26} \times 10^{52}$ erg and $E_\mathrm{p, rest}\simeq280$ keV, respectively, which is consistent with the Amati relation. The absence of a jet break in the optical light curve provides a lower limit on the half-opening angle of the jet $\theta=6.1$ deg. The observed $E_\mathrm{peak}$ is consistent with the limit derived from the Ghirlanda relation. The joint Fermi GBM and Konus-Wind analysis shows that GRB 140801A could belong to the class of intermediate duration. The rapid detection of the optical counterpart of GRB 140801A is especially important regarding the upcoming experiments with large coordinate error-box areas.Comment: in press MNRAS, 201

Узкополосная фототерапия и препарат натриевой соли синтетического дипептида гамма-D-глутамил-D-триптофана в качестве комбинированного метода лечения псориаза: комплексная и сравнительная оценка

The paper presents the results of a comparative study of various immunosuppressive treatment methods of medium severity vulgar psoriasis (PASI from 10 to 20). The parameters used were PASI indices, p53 apoptosis marker expression indices, and expression indices of T-regulatory cell marker Foxp3. The study involved 96 patients, from 18 to 60 years old, divided by randomization into three groups. Patients in the 1st group (n = 32) received narrow-band phototherapy according to a 4-day regimen. We used the Waldmann UV-7002K instrument and F79/120W-TL01 lamps generating radiation with a maximum emission at a wavelength of 311 nm. We started with a dose of 0.05–0.1 J/cm2, subsequently increased by 0.05–0.1 J/cm2 for each procedure, in the absence of erythema. In total, patients received 12–15 procedures, with a course dose of 4.7–7.65 J/cm2. In the 2nd group (n = 32), patients were treated with the sodium salt of the synthetic gamma-D-glutamyl-D tryptophan dipeptide. Patients of the 3rd group (n = 32) underwent combination therapy, which included both methods described above. As a result of treatment, the greatest decrease in the PASI index, as well as the level of expression of the marker of Foxp3 T-regulatory cells, was observed among patients who received the combined regimen. The data obtained indicate the high therapeutic efficacy of narrow-band phototherapy in combination with the sodium salt of the synthetic gamma-D glutamyl-D tryptophan synthetic dipeptide. It was also noted that the immunohistochemical marker p53, reflecting the cellular renewal of psoriatic papule keratinocytes, is an informative molecular-cellular indicator of the effectiveness of narrow-band phototherapy.В работе представлены результаты сравнительного исследования различных иммуносупрессивных методов лечения вульгарного псориаза среднетяжёлой степени (PASI от 10 до 20). В качестве оцениваемых параметров использовали индекс PASI, уровни экспрессии маркера апоптоза р53 и экспрессии маркера Т-регуляторных клеток Foxp3. В исследование были включены 96 пациентов в возрасте от 18 до 60 лет, разделённые методом рандомизации на три группы. Пациенты в 1-й группе (n=32) получали узкополосную фототерапию по 4-дневной схеме. Использовали прибор «Waldmann UV-7002K» и лампы F79/120W-TL01, генерирующие излучение с максимальной эмиссией на длине волны 311 нм. Начинали с дозы 0,05 – 0,1 Дж/см2, повышая в последующем на 0,05 – 0,1 Дж/см2 каждую процедуру, при отсутствии эритемы. Всего пациенты получали от 12 до 15 процедур с курсовой дозой облучения 4,7 –7,65 Дж/см2. Во 2-й группе (n=32) пациентам проводили терапию натриевой солью синтетического дипептида гамма-D-глутамил-D-триптофана. Пациентам 3-й группы (n=32) проводили комбинированную терапию, включающую в себя сочетание двух вышеописанных методик. В результате лечения наибольшее снижение индекса PASI, а также уровня экспрессии маркера Т-регуляторных клеток Foxp3 наблюдали среди пациентов, получивших комбинированную схему. Полученные данные свидетельствуют о высо- кой терапевтической эффективности узкополосной фототерапии в комбинации с препаратом натриевой соли синтетического дипептида гамма- D-глутамил-D-триптофана. Также было отмечено, что иммуногистохимический маркер р53, отражающий клеточное обновление кератиноцитов псориатической папулы, является информативным молекулярно-клеточным показателем эффективности узкополосной фототерапии

National cultural autonomy and linguistic rights in Central and Eastern Europe

The theory and practice of national cultural autonomy (NCA) are examined from the perspective of national minorities’ linguistic rights in four countries of Central and Eastern Europe (CEE): Hungary, Estonia, Serbia and Russia. The idea of NCA dates back to the end of the nineteenth century and is based on the principle of ethnic communities’ autonomy—within a multi-ethnic state—to manage their own linguistic and cultural affairs. The notion of NCA was rediscovered in the 1990s and incorporated into the law and practice of the said four countries. Using a comparative approach, the chapter reflects upon NCA’s potential contribution in advancing the linguistic rights of national minorities in CEE. It concludes that, while the actual autonomy afforded to minority institutions in CEE is often restricted, NCA may serve as a platform to articulate concerns of great salience to national minorities, encompassing minority participation and multilingual education

Determination of fission barrier height of Fr 210 and Ra 210 via neutron measurement

Fission barrier heights of short-lived nuclei away from line of β stability are not known reliably. Low-energy fission of Fr210 and Ra210, produced by (d,p) and (d,n) transfer reaction on the re-accelerated unstable beam Fr209 was investigated at HIE-ISOLDE. Four Timepix3 pixel detectors were installed on the body of the ACTAR TPC demonstrator chamber. Polyethylene converters were used for the detection of fast neutrons. Since no significant background was observed, it was possible to measure the spatial distribution of emitted neutrons reflecting the fission excitation function. Subsequent simulations employing the results of the talys code and available data on fission fragment distributions allowed to estimate directly the value of the fission barrier height for the neutron-deficient nucleus Fr210. This first direct measurement confirmed the reduction of the fission barrier compared to available theoretical calculations by 15-30%

Ранние оптические наблюдения семи гамма-всплесков в сравнении с их гамма-рентгеновскими характеристиками на глобальной сети телескопов-роботов МГУ МАСТЕР

Seven gamma-ray bursts – GRB 130907A, GRB 140311B, GRB 140129B, GRB 160227A, GRB 120404A, GRB 110801A, and GRB 120811C were observed by the MSU MASTER (Mobile Astronomical System of TElescope Robots) Global Network. Full automation of the observations provided for obtaining unique data on the properties of early optical radiation accompanying gamma-ray bursts. The data are compared in the optical (MASTER), X-ray (SWIFT X-ray Telescope, XRT) and gamma (SWIFT Burst Alert Telescope, BAT) ranges. Based on the data obtained, two groups are identified, and their radiation mechanisms are revealed. The effect of gamma-ray bursts on the biosphere of the Earth is determined, and the estimates and the scale of such an effect are considered.В статье представлены результаты наблюдений семи гамма-всплесков – GRB 130907A, GRB 140311B, GRB 140129B, GRB 160227A, GRB 120404A, GRB 110801A, GRB 120811C, полученные на телескопах-роботах глобальной сети МГУ «МАСТЕР». Полная автоматизация наблюдений позволила получить уникальные данные о свойствах раннего оптического излучения, сопровождавшего гамма-всплески. Выполнено сравнение данных в оптическом (МАСТЕР), рентгеновском (SWIFTX-rayTelescope (XRT)) и гамма (SWIFTBurstAlertTelescope (BAT)) диапазонах. На основании полученных данных выделены две группы, для которых определен механизм излучения. Также определено воздействие гамма-всплесков на биосферу Земли и рассмотрены оценки и масштаб такого влияния

ЭПЛАН (МАЗЬ, РАСТВОР) – НОВЫЙ ПРЕПАРАТ ДЛЯ МЕСТНОГО ЛЕЧЕНИЯ ИНФЕКЦИИ КОЖИ И МЯГКИХ ТКАНЕЙ В МНОГОПРОФИЛЬНОМ СТАЦИОНАРЕ

The paper presents the results of a multicenter postmarketing clinical laboratory study of Eplan ointment and eplan solution for the topical treatment of skin and soft tissue infections in outpatient, inpatient, and field settings. The results of the study in 793 patients with skin and soft tissue infections of different locations and genesis demonstrate the high clinical efficacy of the medicaments along with their easy-to-use formulation and economic availability. В статье представлены результаты постмаркетингового многоцентрового клинико-лабораторного исследования препаратов Эплан мазь и Эплан раствор, предназначенных для местного лечения инфекции кожи и мягких тканей (ИКМТ) в амбулаторных, стационарных и военно-полевых условиях. Результаты проведенного исследования у 793 больных с ИКМТ различной локализации и генеза демонстрируют высокую клиническую эффективность препаратов наряду с их удобной лекарственной формой и экономической доступностью.

Using functions from fuzzy classes of k-valued logic for decision making based on the results of rating evaluation

IIn this paper we present an approach based on logic functions with fuzzy conditions for constructing a decision support system for rating evaluation of objects. This approach provides an effective and efficient way for separating rating marks into clusters, associated with a control effect directed at a successful functionality of objects in future