Less Is More: How Grantmakers Are Using Simple Financial Metrics

This article explores how the Financial Health Analysis Tool can bridge the gap between the capacity of grantmakers to conduct financial analysis and the need to incorporate financial considerations into both grantmaking and ongoing engagement with grantees. The tool presents four years of key financial indicators in graphs and charts that create a kind of dashboard of a nonprofit\u27s financial health over time. This small set of simple metrics highlights patterns and trends that can help grantmakers and nonprofits see how the financial management of an organization is advancing its mission and strategy. Using a series of interviews with a group of early users of the tool, this article looks at how these metrics are deployed in practice by grantmakers and illustrates three areas where they can be of particular utility: due diligence and evaluating grants; capacity building; and recognizing larger patterns and opportunities

Condiciones orgánicas y correlaciones de fuerza del movimiento estudiantil chileno.: Una aproximación desde la Confech (2011-2015)*

This paper aims at analyzing the organizational changes in the Confederation of Chilean Students (CONFECH) in the period 2011-2015 and the complexities of the process of institutionalization in the context of the government of Sebastián Piñera and the subsequent administration of Michelle Bachelet. It argues, in the main, that the processes of growth and fragmentation of space CONFECH have generated an increase in the cost of decision-making and collective coordination has become more complex political management capacity of the Executive Board

Modelo geométrico para construir la ecuación de segundo grado

En este artículo1 se presentan una serie de reflexiones acerca de un trabajo de investigación en el aula realizado en el Centro Distrital John F. Kennedy. El tema de matemáticas sobre el que se centró la investigación fue la construcción de la expresión algebraica de una ecuación de segundo grado aplicando el concepto de área de un rectángulo. Hemos dividido la presentación del trabajo en dos partes. En la primera, se da cuenta de un diagnóstico en el que se indagó acerca del estado de conocimiento de los estudiantes con respecto al tema y también sobre algunas de sus características socio-económicas. En la segunda, se presenta el análisis curricular realizado alrededor del tema y cuyo propósito era apoyar la realización del diseño de una actividad de aula de noventa minutos. En los procesos anteriores se tuvieron en cuenta algunas pautas de análisis didáctico tales como proponer un modelo sobre la estructura matemática del tema, indagar sobre el conocimiento previo de los estudiantes acerca de los prerrequisitos necesarios para abordar el tema y la forma como usualmente se ha enfocado la enseñanza del tema en nuestro contexto

L'espansione mondiale del cristianesimo nel secondo Novecento

Profilo della storia del cristianesimo e delle Chiese nel secondo Novecento fino alla fine della guerra fredda, con attenzione alle dinamiche generali e alle principali vicende dei diversi contesti macroregionali e un approfondimento sul ruolo delle donne nelle Chiese in età contemporanea. INDICE Dinamiche nel protestantesimo nel secondo Novecento - 375, Il cristianesimo tra oppressione, liberazione, giustizia sociale. Le Chiese in America Latina e nei Caraibi - 377, Le Chiese nell’America Settentrionale 386, Il cristianesimo in Africa 391, Le Chiese in India - 394, Le Chiese in Estremo Oriente e nel Sud-Est asiatico 395, Donne, cristianesimo e Chiese nel secondo Novecento - 399, Cambiamenti nel pontificato romano: il 1978 - 401, Alla fine della guerra fredda: il cristianesimo e le Chiese tra dinamiche globali e regionali – 404, Bibliografia ragionata - 40

BRAF and TERT mutations in papillary thyroid cancer patients of Latino ancestry.

Papillary thyroid cancer (PTC) is the second most commonly diagnosed malignancy in U.S. Latinas and in Colombian women. Studies in non-Latinos indicate that BRAF and TERT mutations are PTC prognostic markers. This study aimed to determine the prevalence and clinical associations of BRAF and TERT mutations in PTC Latino patients from Colombia. We analyzed mutations of BRAF (V600E) and TERT promoter (C228T, C250T) in tumor DNA from 141 patients (75 with classical variant PTC, CVPTC; 66 with follicular variant PTC, FVPTC) recruited through a multi-center study. Associations between mutations and clinical variables were evaluated with Fisher exact tests. Survival was evaluated with Kaplan-Meier plots. Double-mutant tumors (BRAF+/TERT+, n = 14 patients) were more common in CVPTC (P = 0.02). Relative to patients without mutations (n = 48), double mutations were more common in patients with large tumors (P = 0.03), lymph node metastasis (P = 0.01), extra-thyroid extension (P = 0.03), and advanced stage (P = 6.0 × 10-5). In older patients, TERT mutations were more frequent (mean age 51 years vs 45 years for wild type TERT, P = 0.04) and survival was lower (HR = 1.20; P = 0.017); however, given the small sample size, the decrease in survival was not statically significant between genotypes. Comparisons with published data in US whites revealed that Colombian patients had a higher prevalence of severe pathological features and of double-mutant tumors (10 vs 6%, P = 0.001). Mutations in both oncogenes show prognostic associations in Latinos from Colombia. Our study is important to advance Latino PTC precision medicine and replicates previous prognostic associations between BRAF and TERT in this population

Understanding prime ministerial leadership in the United Kingdom and Japan in the twenty-first century: introduction to a special issue

The introduction to this special issue begins by presenting a recent puzzle – the increasingly strong position of the Japanese prime minister, who has traditionally been regarded as weak, in contrast to the increasingly fragile position of the United Kingdom prime minister, who has traditionally been regarded as strong. To make sense of these developments, the introduction reviews existing academic perspectives related to prime ministerial leadership with a specific focus on the literature on the UK and Japanese prime ministers. It subdivides our understanding of prime ministerial leadership into three distinct but inter-related levels of analysis. First, the institutional setting, which concentrates attention upon prime ministers’ relations with the machinery of government and a range of institutions including the executive, legislature and judiciary, and relates to prime ministerial versus cabinet government debates, and the core-executive model. Second, the party context, which focuses on prime ministers as leaders of their political parties and debates surrounding party centralisation, internal party cohesion and leadership selection and ejection. Third, the role of agency within these above two settings and in relation to the broader public, which includes the personal skills and performative styles of individual prime ministers

Quantum Films Adsorbed on Graphite: Third and Fourth Helium Layers

Using a path-integral Monte Carlo method for simulating superfluid quantum films, we investigate helium layers adsorbed on a substrate consisting of graphite plus two solid helium layers. Our results for the promotion densities and the dependence of the superfluid density on coverage are in agreement with experiment. We can also explain certain features of the measured heat capacity as a function of temperature and coverage.Comment: 13 pages in the Phys. Rev. two-column format, 16 Figure

Smooth-muscle myosin mutations in hereditary non-polyposis colorectal cancer syndrome

We examined adenomas and cancers from hereditary non-polyposis colorectal cancer (HNPCC) syndrome patients for the presence of frameshift mutations in the smooth-muscle myosin gene, MYH11. Our results show that mutations in MYH11 occur more frequently in cancers than adenomas (P=0.008) and are dependent on microsatellite instability (MSI+)