Contact-induced charge contributions to non-local spin transport measurements in Co/MgO/graphene devices

Recently, it has been shown that oxide barriers in graphene-based non-local spin-valve structures can be the bottleneck for spin transport. The barriers may cause spin dephasing during or right after electrical spin injection which limit spin transport parameters such as the spin lifetime of the whole device. An important task is to evaluate the quality of the oxide barriers of both spin injection and detection contacts in a fabricated device. To address this issue, we discuss the influence of spatially inhomogeneous oxide barriers and especially conducting pinholes within the barrier on the background signal in non-local measurements of graphene/MgO/Co spin-valve devices. By both simulations and reference measurements on devices with non-ferromagnetic electrodes, we demonstrate that the background signal can be caused by inhomogeneous current flow through the oxide barriers. As a main result, we demonstrate the existence of charge accumulation next to the actual spin accumulation signal in non-local voltage measurements, which can be explained by a redistribution of charge carriers by a perpendicular magnetic field similar to the classical Hall effect. Furthermore, we present systematic studies on the phase of the low frequency non-local ac voltage signal which is measured in non-local spin measurements when applying ac lock-in techniques. This phase has so far widely been neglected in the analysis of non-local spin transport. We demonstrate that this phase is another hallmark of the homogeneity of the MgO spin injection and detection barriers. We link backgate dependent changes of the phase to the interplay between the capacitance of the oxide barrier to the quantum capacitance of graphene.Comment: 19 pages, 7 figure

Evaluation of the radionuclide tracer test conducted at the project Gnome Underground Nuclear Test Site, New Mexico

A radionuclide tracer test was conducted in 1963 by the U.S. Geological Survey at the Project Gnome underground nuclear test site, approximately 40 km southeast of Carlsbad, New Mexico. The tracer study was carried out under the auspices of the U.S. Atomic Energy Commission (AEC) to study the transport behavior of radionuclides in fractured rock aquifers. The Culebra Dolomite was chosen for the test because it was considered to be a reasonable analogue of the fractured carbonate aquifer at the Nevada Test Site (NTS), the principal location of U.S. underground nuclear tests. Project Gnome was one of a small number of underground nuclear tests conducted by the AEC at sites distant from the NTS. The Gnome device was detonated on December 10, 1961 in an evaporate unit at a depth of 360 m below ground surface. Recently, the U.S. Department of Energy (DOE) implemented an environmental restoration program to characterize, remediate, and close these offsite nuclear test areas. An early step in this process is performance of a preliminary risk analysis of the hazard posed by each site. The Desert Research Institute has performed preliminary hydrologic risk evaluations for the groundwater transport pathway at Gnome. That evaluation included the radioactive tracer test as a possible source because the test introduced radionuclides directly into the Culebra Dolomite, which is the only aquifer at the site. This report presents a preliminary evaluation of the radionuclide tracer test as a source for radionuclide migration in the Culebra Dolomite. The results of this study will assist in planning site characterization activities and refining estimates of the radionuclide source for comprehensive models of groundwater transport st the Gnome site

Influence of rest on players’ performance and physiological responses during basketball play

Pre-match warm-ups are standard in many sports but the focus has excluded the substitute players. The aim of this research was to investigate the result of inactivity on physiological and performance responses in substitute basketball players during competition. Two basketball players from the second tier of the State League of Queensland, Australia volunteered for this study and were assessed for performance (countermovement jump—CMJ) and physiological (core temperature via ingestible pill; skin temperature at the arm, chest, calf and thigh; heart rate—HR) responses prior to and following a 20-min warm-up, and during the first half of a competitive basketball match (2 × 20-min real time quarters). Warm up resulted in increases in CMJ (~7%), HR (~100 bpm) and core (~0.8 °C) and skin (~1.0 °C) temperatures. Following the warm up and during inactivity, substitute players exhibited a decrease in all responses including CMJ (~13%), HR (~100 bpm), and core (~0.5 °C) and skin (~2.0 °C) temperatures. Rest resulted in reductions in key performance and physiological responses during a competitive match that poses a risk for match strategies. Coaches should consider implementing a warm up to enhance core/skin temperature for substitute players immediately before they engage with competition to optimise player performance

Assessing Recharge and Geological Model Uncertainty at the Climax Mine Area of the Nevada Test Site

Hydrologic analyses are commonly based on a single conceptual-mathematical model. Yet hydrologic environments are open and complex, rendering them prone to multiple interpretations and mathematical descriptions. Considering conceptual model uncertainty is a critical process in hydrologic uncertainty assessment. This study assesses recharge and geologic model uncertainty for the Climax mine area of the Nevada Test Site, Nevada. Five alternative recharge models have been independently developed for Nevada and the Death Valley area of California. These models are (1) the Maxey-Eakin model, (2 and 3) a distributed parameter watershed model with and without a runon-runoff component, and (4 and 5) a chloride mass-balance model with two zero-recharge masks, one for alluvium and one for both alluvium and elevation. Similarly, five geological models have been developed based on different interpretations of available geologic information. One of them was developed by the U.S. Geological Survey for the Death Valley Regional Flow System (DVRFS) model; the other four were developed by Bechtel Nevada for the Yucca Flat Corrective Action Unit (CAU). The Climax mine area is in the northern part of the Yucca Flat CAU, which is within the DVRFS. A total of 25 conceptual models are thus formulated based on the five recharge and five geologic models. The objective of our work is to evaluate the conceptual model uncertainty, and quantify its propagation through the groundwater modeling process. A model averaging method is applied that formally incorporates prior information and field measurements into our evaluation. The DVRFS model developed by the U.S. Geological Survey is used as the modeling framework, into which the 25 models are incorporated. Conceptual model uncertainty is first evaluated through expert elicitation based on prior information possessed by two expert panels. Their perceptions of model plausibility are quantified as prior model probabilities, which are then updated by the site measurements of head and flux through inverse modeling. Posterior model probabilities of the models are then evaluated after the updating process, and used as weights in the summation of each model's mean predictions and associated predictive uncertainty. Deterministic simulation results using calibrated parameters are examined to investigate different model predictions of each alternative model. Parametric uncertainty of each model is assessed using Monte Carlo simulation, and the uncertainty is compared for each model to evaluate uncertainty bounds. Finally, the uncertainty bounds of model averaging, incorporating both parametric and conceptual model uncertainty, are evaluated and compared with those of individual models. It is shown that model averaging provides larger uncertainty bounds, indicating that more uncertainty is incorporated, rendering model predictions more scientifically defensible

Using Uncertainty to Guide Characterization, Closure and Long-term Management of an Underground Nuclear Test Site

No feasible remediation technology has been identified for nuclear test cavities such that site management and institutional controls must be relied on to minimize the possibility of public exposure to these legacies of the Cold War. The most common exposure pathway of concern is migration of radionuclides with groundwater. Prediction of flow and transport behavior in the sparsely observed subsurface environment is inherently uncertain, but developing effective management strategies demands such predictions. An agreement between the U.S. Department of Energy (DOE) and the State of Nevada provides a framework for addressing uncertainty in site management decisions. The central element of the framework is calculation of a predictive contaminant boundary at a specified confidence interval. This boundary is defined as a three-dimensional region encompassing all groundwater that contains radionuclides at concentrations higher than Safe Drinking Water Act limits at any time through a 1,000-year period, at a 95-percent confidence interval. In the process of predicting this boundary at the Shoal underground nuclear test site in rural Nevada, some interesting challenges were encountered. A stochastic groundwater flow and transport model was developed for the site using historic site data and information from four characterization wells drilled in 1996. Though the predicted mean transport plume was located within the existing site land boundary, uncertainty in the predictions was very large such that the 95-percent confidence interval extended beyond the site boundary. This level of uncertainty was unacceptable to DOE, prompting additional site characterization with the goal of reducing the uncertainty in contaminant migration predictions. The numerical groundwater flow model was used to identify the optimum data collection activities for uncertainty reduction. This Data Decision Analysis guided drilling and testing of additional wells. Significant revision occurred to the groundwater model as a result of the new data. The revised model was deemed acceptable by both DOE and the State of Nevada, and has been used to determine the contaminant boundary for the site, the calculation of which required choices regarding risk or concentration metrics and whether to focus on the uncertainty of where the contaminants might be or where the groundwater is free of contaminants. The model was also used to develop an optimum monitoring system, the installation of which provided another opportunity to reduce uncertainty as data were collected for model validation. The short-term validation process, and long-term monitoring, provide data that can feed back into the stochastic flow and transport model to cull poorly performing model realizations and reduce uncertainty in the model predictions

Skill and added value of the MiKlip regional decadal prediction system for temperature over Europe

In recent years, several decadal prediction systems have been developed to provide multi-year predictions of the climate for the next 5–10 years. On the global scale, high decadal predictability has been identified for the North Atlantic sector, often extending over Europe. The first full regional hindcast ensemble, derived from dynamical downscaling, was produced within the German MiKlip project (‘decadal predictions’). The ensemble features annual starting dates from 1960 to 2017, with 10 decadal hindcasts per starting year. The global component of the prediction system uses the MPI-ESM-LR and the downscaling is performed with the regional climate model COSMO-CLM (CCLM). The present study focusses on a range of aspects dealing with the skill and added value of regional decadal temperature predictions over Europe. The results substantiate the added value of the regional hindcasts compared to the forcing global model as well as to un-initialized simulations. The results show that the hindcasts are skilful both for annual and seasonal means, and that the scores are comparable for different observational reference data sets. The predictive skill increases from earlier to more recent start-years. A recalibration of the simulation data generally improves the skill further, which can also be transferred to more user-relevant variables and extreme values like daily maximum temperatures and heating degree-days. These results provide evidence of the potential for the regional climate predictions to provide valuable climate information on the Abstract Formulae display:MathJax Logo? In recent years, several decadal prediction systems have been developed to provide multi-year predictions of the climate for the next 5–10 years. On the global scale, high decadal predictability has been identified for the North Atlantic sector, often extending over Europe. The first full regional hindcast ensemble, derived from dynamical downscaling, was produced within the German MiKlip project (‘decadal predictions’). The ensemble features annual starting dates from 1960 to 2017, with 10 decadal hindcasts per starting year. The global component of the prediction system uses the MPI-ESM-LR and the downscaling is performed with the regional climate model COSMO-CLM (CCLM). The present study focusses on a range of aspects dealing with the skill and added value of regional decadal temperature predictions over Europe. The results substantiate the added value of the regional hindcasts compared to the forcing global model as well as to un-initialized simulations. The results show that the hindcasts are skilful both for annual and seasonal means, and that the scores are comparable for different observational reference data sets. The predictive skill increases from earlier to more recent start-years. A recalibration of the simulation data generally improves the skill further, which can also be transferred to more user-relevant variables and extreme values like daily maximum temperatures and heating degree-days. These results provide evidence of the potential for the regional climate predictions to provide valuable climate information on the decadal time-scale to users

Comparative effectiveness of levetiracetam, valproate and carbamazepine among elderly patients with newly diagnosed epilepsy: subgroup analysis of the randomized, unblinded KOMET study

BACKGROUND: Few clinical trials have evaluated the efficacy and tolerability of antiepileptic drugs (AEDs) as initial monotherapy for elderly patients. METHODS: This post-hoc subgroup analysis of data from an unblinded, randomized, 52-week superiority study (KOMET) compared the effectiveness of levetiracetam (LEV) with extended-release sodium valproate (VPA-ER) and controlled-release carbamazepine (CBZ-CR) as monotherapy in patients aged 60 years with newly diagnosed epilepsy. The physician chose VPA or CBZ as preferred standard treatment; patients were randomized to standard AEDs or LEV. The primary endpoint was time to treatment withdrawal. Results are exploratory, since KOMET was not powered for a subgroup analysis by age. RESULTS: Patients (n = 308) were randomized to LEV (n = 48) or VPA-ER (n = 53) in the VPE-ER stratum or to LEV (n = 104) or CBZ-CR (n = 103) in the CBZ-CR stratum. Mean age was 69.6 years, range 60.2-89.9 years (intention-to-treat population n = 307). Time to treatment withdrawal hazard ratio [HR] (95 % confidence interval [CI]) for LEV vs. standard AEDs was 0.44 (0.28-0.67); LEV vs. VPA-ER: 0.46 (0.16-1.33); LEV vs. CBZ-CR: 0.45 (0.28-0.72). Twelve-month withdrawal rates were: LEV vs. standard AEDs, 20.4 vs. 38.7 %; LEV vs. VPA-ER, 10.4 vs. 23.1 %; LEV vs. CBZ-CR, 25.0 vs. 46.6 %. Time to first seizure was similar between LEV and standard AEDs (HR: 0.92, 95 % CI: 0.63-1.35), LEV and VPA-ER (0.77, 0.38-1.56), and LEV and CBZ-CR (1.02, 0.64-1.63). Adverse events were reported by 76.2, 67.3, and 82.5 % of patients for LEV, VPA-ER, and CBZ-CR, respectively. Discontinuation rates due to AEs were 11.3, 10.2, and 35.0 % for LEV, VPA-ER, and CBZ-CR, respectively.CONCLUSIONS: Time to treatment withdrawal was longer with LEV compared with standard AEDs. This finding was driven primarly by the result in the CBZ-CR stratum, which in turn was likely due to the more favorable tolerability profile of LEV. Results of this post-hoc analysis suggest that LEV(VLID)195291

Magnetism and domain formation in SU(3)-symmetric multi-species Fermi mixtures

We study the phase diagram of an SU(3)-symmetric mixture of three-component ultracold fermions with attractive interactions in an optical lattice, including the additional effect on the mixture of an effective three-body constraint induced by three-body losses. We address the properties of the system in $D \geq 2$ by using dynamical mean-field theory and variational Monte Carlo techniques. The phase diagram of the model shows a strong interplay between magnetism and superfluidity. In the absence of the three-body constraint (no losses), the system undergoes a phase transition from a color superfluid phase to a trionic phase, which shows additional particle density modulations at half-filling. Away from the particle-hole symmetric point the color superfluid phase is always spontaneously magnetized, leading to the formation of different color superfluid domains in systems where the total number of particles of each species is conserved. This can be seen as the SU(3) symmetric realization of a more general tendency to phase-separation in three-component Fermi mixtures. The three-body constraint strongly disfavors the trionic phase, stabilizing a (fully magnetized) color superfluid also at strong coupling. With increasing temperature we observe a transition to a non-magnetized SU(3) Fermi liquid phase.Comment: 36 pages, 17 figures; Corrected typo

A taste of the deep-sea: The roles of gustatory and tactile searching behaviour in the grenadier fish <i>Coryphaenoides armatus</i>

The deep-sea grenadier fishes (Coryphaenoides spp.) are among the dominant predators and scavengers in the ocean basins that cover much of Earth's surface. Baited camera experiments were used to study the behaviour of these fishes. Despite the apparent advantages of rapidly consuming food, grenadiers attracted to bait spend a large proportion of their time in prolonged periods of non-feeding activity. Video analysis revealed that fish often adopted a head-down swimming attitude (mean of 21.3 degrees between the fish and seafloor), with swimming velocity negatively related to attitude. The fish also swam around and along vertical and horizontal structures of the lander with their head immediately adjacent to the structure. We initially hypothesised that this behaviour was associated with the use of the short chin barbel in foraging. Barbel histology showed numerous taste buds in the skin, and a barbel nerve with about 20,000 axons in adult fish. A tracing experiment in one undamaged animal revealed the termination fields of the barbel neurons in the trigeminal and rhombencephalic regions, indicating both a mechanoreceptory and a gustatory role for the barbel. Our conclusion was that olfactory foraging becomes ineffective at close ranges and is followed by a search phase using tactile and gustatory sensing by the barbel. The development of this sensory method probably co-evolved alongside behavioural changes in swimming mechanics to allow postural stability at low swimming speeds

Development and use of lentiviral vectors pseudotyped with influenza B haemagglutinins: application to vaccine immunogenicity, mAb potency and sero-surveillance studies

Influenza B viruses cause respiratory disease epidemics in human populations and are included in seasonal influenza vaccines. Serological methods are employed to evaluate vaccine immunogenicity prior to licensure. However, the haemagglutination inhibition assay, which represents the gold standard for assessing the immunogenicity of influenza vaccines, has been shown to be relatively insensitive for the detection of antibodies against influenza B viruses. Furthermore, this assay, and the serial radial haemolysis assay are not able to detect stalk-directed cross-reactive antibodies. For these reasons there is a need to develop new assays that can overcome these limitations. The use of replication-defective viruses, such as lentiviral vectors pseudotyped with influenza A haemagglutinins, in microneutralization assays is a safe and sensitive alternative to study antibody responses elicited by natural infection or vaccination. We have produced Influenza B haemagglutinin-pseudotypes using plasmid-directed transfection. To activate influenza B haemagglutinin, we have explored the use of proteases by adding relevant encoding plasmids to the transfection mixture. When tested for their ability to transduce target cells, the newly produced influenza B pseudotypes exhibit tropism for different cell lines. Subsequently the pseudotypes were evaluated as surrogate antigens in microneutralization assays using reference sera, monoclonal antibodies, human sera collected during a vaccine immunogenicity study and surveillance sera from seals. The influenza B pseudotype virus neutralization assay was found to effectively detect neutralizing and cross-reactive responses despite lack of significant correlation with the haemagglutinin inhibition assay