441 research outputs found
Reentrance of disorder in the anisotropic shuriken Ising model
For a material to order upon cooling is common sense. What is more seldom is
for disorder to reappear at lower temperature, which is known as reentrant
behavior. Such resurgence of disorder has been observed in a variety of
systems, ranging from Rochelle salts to nematic phases in liquid crystals.
Frustration is often a key ingredient for reentrance mechanisms. Here we shall
study a frustrated model, namely the anisotropic shuriken lattice, which offers
a natural setting to explore an extension of the notion of reentrance between
magnetic disordered phases. By tuning the anisotropy of the lattice, we open a
window in the phase diagram where magnetic disorder prevails down to zero
temperature. In this region, the competition between multiple disordered ground
states gives rise to a double crossover where both the low- and
high-temperature regimes are less correlated than the intervening classical
spin liquid. This reentrance of disorder is characterized by an entropy
plateau, a multi-step Curie law crossover and a rather complex diffuse
scattering in the static structure factor. Those results are confirmed by
complementary numerical and analytical methods: Monte Carlo simulations,
Husimi-tree calculations and an exact decoration-iteration transformation.Comment: 16 pages, 13 figure
Curie-law crossover in spin liquids
The Curie-Weiss law is widely used to estimate the strength of frustration in
frustrated magnets. However, the Curie-Weiss law was originally derived as an
estimate of magnetic correlations close to a mean-field phase transition, which
-- by definition -- is absent in spin liquids. Instead, the susceptibility of
spin liquids is known to undergo a Curie-law crossover between two magnetically
disordered regimes. Here, we study the generic aspect of the Curie-law
crossover by comparing a variety of frustrated spin models in two and three
dimensions, using both classical Monte Carlo simulations and analytical Husimi
tree calculations. Husimi tree calculations fit remarkably well the simulations
for all temperatures and almost all lattices. We also propose a Husimi Ansatz
for the reduced susceptibility , to be used in complement to the
traditional Curie-Weiss fit in order to estimate the Curie-Weiss temperature
. Applications to materials are discussed.Comment: 26 pages, 15 figure
The efficacy of halofantrine in the treatment of acute malaria in nonimmune travelers
A multicenter prospective trial was performed to investigate the efficacy and the tolerability of halofantrine in nonimmune patients with malaria imported from areas with drug-resistant falciparum parasites (mainly Africa). Forty-five of the 74 subjects were treated with a one-day regimen (3 x 500 mg) of halofantrine, and the other 29 received the same regimen with an additional treatment on day 7. In the second group, a 100% efficacy rate was demonstrated, but in the group receiving the one-day regimen, four recrudescences were observed in patients with falciparum malaria. Only five mild adverse reactions were seen, which disappeared spontaneously after the end of the treatment. We conclude that halofantrine is highly effective in curing malaria in nonimmune subjects. The treatment scheme for such persons should include an additional treatment on day 7 for nonimmune individuals. This drug was well tolerated in our patients, indicating that halofantrine will be useful in the treatment of multidrug-resistant malaria in nonimmune persons
Electrostatic extraction of cold molecules from a cryogenic reservoir
We present a method which delivers a continuous, high-density beam of slow
and internally cold polar molecules. In our source, warm molecules are first
cooled by collisions with a cryogenic helium buffer gas. Cold molecules are
then extracted by means of an electrostatic quadrupole guide. For ND the
source produces fluxes up to molecules/s with
peak densities up to molecules/cm. For
HCO the population of rovibrational states is monitored by depletion
spectroscopy, resulting in single-state populations up to .Comment: 4 pages, 4 figures, changes to the text, updated figures and
reference
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Testing Quantile Forecast Optimality
Quantile forecasts made across multiple horizons have become an important output of many financial institutions, central banks and international organizations. This article proposes misspecification tests for such quantile forecasts that assess optimality over a set of multiple forecast horizons and/or quantiles. The tests build on multiple Mincer-Zarnowitz quantile regressions cast in a moment equality framework. Our main test is for the null hypothesis of autocalibration, a concept which assesses optimality with respect to the information contained in the forecasts themselves. We provide an extension that allows to test for optimality with respect to larger information sets and a multivariate extension. Importantly, our tests do not just inform about general violations of optimality, but may also provide useful insights into specific forms of sub-optimality. A simulation study investigates the finite sample performance of our tests, and two empirical applications to financial returns and U.S. macroeconomic series illustrate that our tests can yield interesting insights into quantile forecast sub-optimality and its causes
Socially-mediated arousal and contagion within domestic chick broods
Emotional contagion – an underpinning valenced feature of empathy – is made up of simpler, potentially dissociable social processes which can include socially-mediated arousal and behavioural/physiological contagion. Previous studies of emotional contagion have often conflated these processes rather than examining their independent contribution to empathic response. We measured socially-mediated arousal and contagion in 9-week old domestic chicks (n = 19 broods), who were unrelated but raised together from hatching. Pairs of observer chicks were exposed to two conditions in a counterbalanced order: air puff to conspecifics (AP) (during which an air puff was applied to three conspecifics at 30 s intervals) and control with noise of air puff (C) (during which the air puff was directed away from the apparatus at 30 s intervals). Behaviour and surface eye temperature of subjects and observers were measured throughout a 10-min pre-treatment and 10-min treatment period. Subjects and observers responded to AP with increased freezing, and reduced preening and ground pecking. Subjects and observers also showed reduced surface eye temperature - indicative of stress-induced hyperthermia. Subject-Observer behaviour was highly correlated within broods during both C and AP conditions, but with higher overall synchrony during AP. We demonstrate the co-occurrence of socially-mediated behavioural and physiological arousal and contagion; component features of emotional contagion
Chemoenzymatic Probes for Detecting and Imaging Fucose-α(1-2)-galactose Glycan Biomarkers
The disaccharide motif fucose-α(1-2)-galactose (Fucα(1-2)Gal) is involved in many important physiological processes, such as learning and memory, inflammation, asthma, and tumorigenesis. However, the size and structural complexity of Fucα(1-2)Gal-containing glycans have posed a significant challenge to their detection. We report a new chemoenzymatic strategy for the rapid, sensitive detection of Fucα(1-2)Gal glycans. We demonstrate that the approach is highly selective for the Fucα(1-2)Gal motif, detects a variety of complex glycans and glycoproteins, and can be used to profile the relative abundance of the motif on live cells, discriminating malignant from normal cells. This approach represents a new potential strategy for biomarker detection and expands the technologies available for understanding the roles of this important class of carbohydrates in physiology and disease
Is there a role of statins in the prevention of aortic biological prostheses degeneration
It has been recently observed that statins might slow the progression of aortic stenosis or sclerosis. Preliminary reports suggested a similar positive effect in reducing the degeneration of aortic valve bioprostheses even though this hypothesis should be further proven and supported by new data. In this review the present evidences of the possible effects of statins in this field are discussed
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