Value and utility in a historical perspective

Since value and utility are the highest profile abstractions that underlie an epoch’s intellectual climate and ethical principles, their evolution reflects the transformation of socioeconomic conditions and institutions. The “Classical Phase” flourished during the first global system, laissez-faire/metal money/zero multilateralism (GS1); the second, “Subjective/Utilitarian” phase marked the long transition to the current epoch of “Modern Subjectivism/General Equilibrium,” tied to the second and extant global system, mixed economy/minimum reserve banking/weak multilateralism (GS2). History has witnessed the material de-essentialization of value and substantialization of utility. But now the two concepts face a thorough transvaluation as the world’s combined demographic and economic expansion encounters ecological/physical limitations. An extended macrohistoric implosion may lead to a third form of global self-organization: two-level economy/maximum bank reserve money/strong multilateralism (GS3). If history unfolds along the suggested path, not only economics, but also thinking about economics would change. It would be considered an evolving hermeneutic of the human condition expressed through global-system-specific texts. The implied critical alteration, with the recognition of the entropy law’s importance as its focal point, matches the prediction of Swiss thinker Jean Gebser (1905-1973) about the impending mutation of human consciousness into its integral/arational structure. Such extrapolations form the context in which the fourth historical phase of value and utility is hypothesized, leading to the material re-essentialization of value and de-substantialization of utility

Activation of \u3cem\u3eTomato Bushy Stunt Virus\u3c/em\u3e RNA-Dependent RNA Polymerase by Cellular Heat Shock Protein 70 Is Enhanced by Phospholipids \u3cem\u3eIn Vitro\u3c/em\u3e

Similar to other positive-strand RNA viruses, tombusviruses are replicated by the membrane-bound viral replicase complex (VRC). The VRC consists of the p92 virus-coded RNA-dependent RNA polymerase (RdRp), the viral p33 RNA chaperone, and several co-opted host proteins. In order to become a functional RdRp after its translation, the p92 replication protein should be incorporated into the VRC, followed by its activation. We have previously shown in a cell-free yeast extract-based assay that the activation of the Tomato bushy stunt virus (TBSV) RdRp requires a soluble host factor(s). In this article, we identify the cellular heat shock protein 70 (Hsp70) as the co-opted host factor required for the activation of an N-terminally truncated recombinant TBSV RdRp. In addition, small-molecule-based blocking of Hsp70 function inhibits RNA synthesis by the tombusvirus RdRp in vitro. Furthermore, we show that neutral phospholipids, namely, phosphatidylethanolamine (PE) and phosphatidylcholine (PC), enhance RdRp activation in vitro. In contrast, phosphatidylglycerol (PG) shows a strong and dominant inhibitory effect on in vitro RdRp activation. We also demonstrate that PE and PC stimulate RdRp-viral plus-strand RNA [(+)RNA] interaction, while PG inhibits the binding of the viral RNA to the RdRp. Based on the stimulatory versus inhibitory roles of various phospholipids in tombusvirus RdRp activation, we propose that the lipid composition of targeted subcellular membranes might be utilized by tombusviruses to regulate new VRC assembly during the course of infection. IMPORTANCE: The virus-coded RNA-dependent RNA polymerase (RdRp), which is responsible for synthesizing the viral RNA progeny in infected cells of several positive-strand RNA viruses, is initially inactive. This strategy is likely to avoid viral RNA synthesis in the cytosol that would rapidly lead to induction of RNA-triggered cellular antiviral responses. During the assembly of the membrane-bound replicase complex, the viral RdRp becomes activated through an incompletely understood process that makes the RdRp capable of RNA synthesis. By using TBSV RdRp, we show that the co-opted cellular Hsp70 chaperone and neutral phospholipids facilitate RdRp activation in vitro. In contrast, phosphatidylglycerol (PG) has a dominant inhibitory effect on in vitro RdRp activation and RdRp-viral RNA interaction, suggesting that the membranous microdomain surrounding the RdRp greatly affects its ability for RNA synthesis. Thus, the activation of the viral RdRp likely depends on multiple host components in infected cells

What’s wrong with the world? Rationality! A critique of economic anthropology in the spirit of Jean Gebser

Jean Gebser (1905-1973) was a multidisciplinary thinker whose ideas about human consciousness and the future inspire the following five vantage points for the heterodox critique of contemporary economic anthropology: (1) Characteristic attributes of consciousness and those of the environment surrounding the individual are equivalent, eliminating the possibility of single-minded, seamless, rational control, especially during macrohistoric phase transitions; (2) Diaphaneity as a mode of deep and comprehensive understanding (an approach that excludes latching on to any selectively focused explanation) will be needed to deal effectively with emerging global resource and environmental problems; (3) Costs in the form of irreversibly accumulating inaccessible energy shadow our evolving civilization, which our cultural conditioning portrays as pure progress; (4) Rationality, as the most laudable motivation for individuals, business firms and nations, has led to an unfounded techno-fetish; and, for various reasons, it fuels accelerated movement toward collective self-destruction; (5) Signs of chaos (not the harmless and controllable kind found in standard economic literature) corroborate the notion that we have entered a new period of macrohistoric phase transition as interpreted by the thermodynamic comprehension of universal history

What’s wrong with the world? Rationality! A critique of economic anthropology in the spirit of Jean Gebser

Jean Gebser (1905-1973) was a multidisciplinary thinker whose ideas about human consciousness and the future inspire the following five vantage points for the heterodox critique of contemporary economic anthropology: (1) Characteristic attributes of consciousness and those of the environment surrounding the individual are equivalent, eliminating the possibility of single-minded, seamless, rational control, especially during macrohistoric phase transitions; (2) Diaphaneity as a mode of deep and comprehensive understanding (an approach that excludes latching on to any selectively focused explanation) will be needed to deal effectively with emerging global resource and environmental problems; (3) Costs in the form of irreversibly accumulating inaccessible energy shadows our evolving civilization, which our cultural conditioning portrays as pure progress; (4) Rationality, as the most laudable motivation for individuals, business firms and nations, has led to an unfounded techno-fetish; and, for various reasons, it fuels accelerated movement toward collective self-destruction; (5) Signs of chaos (not the harmless and controllable kind found in standard economic literature) corroborate the notion that we have entered a new period of macrohistoric phase transition as interpreted by the thermodynamic comprehension of universal history

Thermodynamic Isolation and the New World Order

The general stream of economic thinking is thoroughly a-physical and a-historic. This direction is becoming increasingly absurd as the nexus between the human biomass and its ecological constraints ripens. Economics will eventually have to absorb apodictically that regardless of scientific-technical development and the intensity of entrepreneurial drive, the aggregate, long-run supply of telluric substance-borne free energy is on a path of declining elasticity. To hasten recognition, it would be helpful to consider the Earth an isolated, rather than a closed thermodynamic system. From the perspective of its evolutionary potential, the world is indeed Under the Dome. This paper argues that (a) the emergence of classical capitalism in the 19th century answered the need for global-scale self-organization; (b) this scheme, interrupted by World War I, was replaced after World War II; (c) the implied transformation has been accompanied by a nonarbitrary, causally determined, irreversible socialization of intranational and international economic relations; (d) contemporary civilization is moving toward a new form of self-organization that would recognize limits to demographic-economic expansion. What will it take to go from the current hostile disgust with the dystopia of tightened modes of multilateral governance to people around the world on their knees begging for a planetary guild? It will take nothing less than a mutation in consciousness, as outlined in the oeuvre of Jean Gebser (1905-1973)

Thermodynamic Isolation and the New World Order

The general stream of economic thinking is thoroughly a-physical and a-historic. This direction is becoming increasingly absurd as the nexus between the human biomass and its ecological constraints ripens. Economics will eventually have to absorb apodictically that regardless of scientific-technical development and the intensity of entrepreneurial drive, the aggregate, long-run supply of telluric substance-borne free energy is on a path of declining elasticity. To hasten recognition, it would be helpful to consider the Earth an isolated, rather than a closed thermodynamic system. From the perspective of its evolutionary potential, the world is indeed Under the Dome. This paper argues that (a) the emergence of classical capitalism in the 19th century answered the need for global-scale self-organization; (b) this scheme, interrupted by World War I, was replaced after World War II; (c) the implied transformation has been accompanied by a nonarbitrary, causally determined, irreversible socialization of intranational and international economic relations; (d) contemporary civilization is moving toward a new form of self-organization that would recognize limits to demographic-economic expansion. What will it take to go from the current hostile disgust with the dystopia of tightened modes of multilateral governance to people around the world on their knees begging for a planetary guild? It will take nothing less than a mutation in consciousness, as outlined in the oeuvre of Jean Gebser (1905-1973)

What’s wrong with the world? Rationality! A critique of economic anthropology in the spirit of Jean Gebser

Jean Gebser (1905-1973) was a multidisciplinary thinker whose ideas about human consciousness and the future inspire the following five vantage points for the heterodox critique of contemporary economic anthropology: (1) Characteristic attributes of consciousness and those of the environment surrounding the individual are equivalent, eliminating the possibility of single-minded, seamless, rational control, especially during macrohistoric phase transitions; (2) Diaphaneity as a mode of deep and comprehensive understanding will be needed to deal effectively with emerging global resource and environmental problems; (3) Costs in the form of irreversibly accumulating inaccessible energy shadows economic expansion, which our cultural conditioning portrays as pure progress; (4) Rationality, as the most laudable motivation for individuals, business firms and nations, has led to an unfounded techno-fetish; and, for various reasons, it fuels accelerated movement toward collective self-destruction; (5) Signs of chaos (not the harmless and controllable kind found in standard economic literature) corroborate the notion that we have entered a new period of macrohistoric phase transition as interpreted by the thermodynamic comprehension of universal history

Cell-Free and Cell-Based Approaches to Explore the Roles of Host Membranes and Lipids in the Formation of Viral Replication Compartment Induced by Tombusviruses

Plant positive strand RNA viruses are intracellular infectious agents that take advantage of cellular lipids and membranes to support replication and protect viral RNA from degradation by host antiviral responses. In this review, we discuss how Tomato bushy stunt virus (TBSV) co-opts lipid transfer proteins and modulates lipid metabolism and transport to facilitate the assembly of the membrane-bound viral replicase complexes within intricate replication compartments. Identification and characterization of the proviral roles of specific lipids and proteins involved in lipid metabolism based on results from yeast (Saccharomyces cerevisiae) model host and cell-free approaches are discussed. The review also highlights the advantage of using liposomes with chemically defined composition to identify specific lipids required for TBSV replication. Remarkably, all the known steps in TBSV replication are dependent on cellular lipids and co-opted membranes

Noncanonical Role for the Host Vps4 AAA+ ATPase ESCRT Protein in the Formation of Tomato Bushy Stunt Virus Replicase

Assembling of the membrane-bound viral replicase complexes (VRCs) consisting of viral- and host-encoded proteins is a key step during the replication of positive-stranded RNA viruses in the infected cells. Previous genome-wide screens with Tomato bushy stunt tombusvirus (TBSV) in a yeast model host have revealed the involvement of eleven cellular ESCRT (endosomal sorting complexes required for transport) proteins in viral replication. The ESCRT proteins are involved in endosomal sorting of cellular membrane proteins by forming multiprotein complexes, deforming membranes away from the cytosol and, ultimately, pinching off vesicles into the lumen of the endosomes. In this paper, we show an unexpected key role for the conserved Vps4p AAA+ ATPase, whose canonical function is to disassemble the ESCRT complexes and recycle them from the membranes back to the cytosol. We find that the tombusvirus p33 replication protein interacts with Vps4p and three ESCRT-III proteins. Interestingly, Vps4p is recruited to become a permanent component of the VRCs as shown by co-purification assays and immuno-EM. Vps4p is co-localized with the viral dsRNA and contacts the viral (+)RNA in the intracellular membrane. Deletion of Vps4p in yeast leads to the formation of crescent-like membrane structures instead of the characteristic spherule and vesicle-like structures. The in vitro assembled tombusvirus replicase based on cell-free extracts (CFE) from vps4Δ yeast is highly nuclease sensitive, in contrast with the nuclease insensitive replicase in wt CFE. These data suggest that the role of Vps4p and the ESCRT machinery is to aid building the membrane-bound VRCs, which become nuclease-insensitive to avoid the recognition by the host antiviral surveillance system and the destruction of the viral RNA. Other (+)RNA viruses of plants and animals might also subvert Vps4p and the ESCRT machinery for formation of VRCs, which require membrane deformation and spherule formation