Synthesis, physico-chemical characterization and biological activity of 2-aminobenzimidazole complexes with different metal ions

Complexes of 2-aminobenzimidazole (L) with nitrates of cobalt(II) nickel(II), copper (II), zinc(II) and silver(I) were synthesized. The molar ratio metal:ligand in the reaction of the complex formation was 1:2. It should be noticed, that the reaction of all the metal salts yielded bis(ligand) complexes of the general formula M(L)2(NO3)2 × nH2O (M=Co, Ni Cu, Zn or Ag; n=0, 1, 2 or 6). The complexes were characterized by elemental analysis of the metal, molar conductivity, magnetic susceptibility measurements and IR spectra. Co(II), Ni(II) and Cu(II) complexes behave as non-electrolytes, whilst Zn(II) and Ag(I) are 1:1 electrolytes. Cu(II) complex has a square-planar stereochemistry, Ag(I) complex is linear, whilst the Co(II), Ni(II) and Zn(II) complexes have a tetrahedral configuration. In all the complexes ligand is coordinated by participation of the pyridine nitrogen of the benzimidazole ring. The antimicrobial activity of the ligand and its complexes against Pseudomonas aeruginosa, Bacillus sp. Staphylococcus aureus and Saccharomyces cerevisiae was investigated. The effect of metal on the ligand antimicrobial activity is discussed

Antibacterial evaluation of some benzimidazole derivatives and their zinc(II) complexes

Zinc(II) chloride was reacted with some 1-benzylbenzimidazole derivatives (L) to give complexes of the formula ZnL2Cl2. All the ligands and their zinc(II) complexes were evaluated for their in vitro antibacterial activity against Pseudomonas aeruginosa, Bacillus cereus, Staphylococcus aureus and Sarcina lutea. Themajority of the investigated compounds displayed in vitro antimicrobial activity against very persistent microorganisms. It was found that all the tested compounds were more active against gram-positive than gram-negative bacteria. The minimum inhibitory concentration (MIC) was determined for all ligands and their complexes. The effect of the structure of the ligands and complexes on the antimicrobial activity is discussed. The complexes were found to be more toxic than the ligands

Antibacterial activity of cobalt(II) complexes with some benzimidazole derivatives

The antibacterial activities of cobalt(II) complexes with two series of benzimidazoles were evaluated in vitro against three Gram-positive bacterial strains (Bacillus cereus, Staphylococcus aureus, and Sarcina lutea) and one Gram-negative isolate (Pseudomonas aeruginosa). The minimum inhibitory concentration was determined for all the complexes. The majority of the investtigated complexes displayed in vitro inhibitory activity against very persistent bacteria. They were found to be more active against Gram-positive than Gram-negative bacteria. It may be concluded that the antibacterial activity of the compounds is related to the cell wall structure of the tested bacteria. Comparing the inhibitory activities of the tested complexes, it was found that the 1-substituted-2-aminobenzimidazole derivatives were more active than complexes of 1-substituted-2-amino-5,6-dimethylbenzimidazoles. The effect of chemical structure on the antibacterial activity is discussed

JSCS–3794 Original scientific paper

Antibacterial activity of cobalt(II) complexes with some benzimidazole derivative

Fizičko-hemijska karakterizacija i antibakterijska aktivnost bakar(II), cink(II) i nikal(II) kompleksa sa 2-metilbenzimidazolom

Chlorides and nitrates of copper(II), zinc(II) and nickel(II) react with 2-methylbenzimidazole to give complexes of the type [MX2(H2O))n(L).nH20 or [MX2(H2O)n(L)n]-nEtOH(M=Cu, Zn or Ni; X=Cl or NO3; L-=2-methylbenzimidazole; n=O, 1,2 or 3). The complexes were synthesized and characterized by elemental analysis, molar conductivity, magnetic susceptibility measurements and IR spectra. These studies suggest that the complexes of zinc and nickel possess a tetrahedral stereochemistry, while those of copper have square-planar geometries. The antibacterial activity of the 2-methylbenzimidazole and its complexes was evaluated against Escherichia coli and Bacillus sp.Hloridi i nitrati bakra(II), i nikla (II) i nikla(II) reaguju sa 2-metilbenzimidazolom dajući komplekse tipa [MX2,(H2O)n(L)n].nH2O ili [MX2,(H2O)n(L)n].nEtOH(M=Su, Zn ili Ni; X=Cl ili NO3; L=2 metilbenzimidazol; n=0, 1 ,2 ili 3). Kompleksi su sintetisani i okarakterisani elementarnom analizom, magnetnim i konduktometrijskim merenjima i IR spektrima. Za komplekse cinka (II) i nikla(II) prstpostavljena je tetraedarska struktura, dok je kompleksu bakra (II) pripisana kvadratno-planarna geometrija. Ispitana je antibakterijska aktivnost 2-metil-benzimidazola i njegovih kompleksa na bakterije Escherichia coli i Bacillus sp

Chemometric estimation of the retention behavior of selected estradiol derivatives

Quantitative structure-retention relationship (QSRR) analysis has been performed in order to correlate the retention of selected estradiol derivatives with their calculated molecular lipophilicity. The lipophilicity descriptors were derived computationally and most important were selected. Linear regression (LR) Wad used for model establishing. Statistical quality of the generated models was determined by standard statistical and crossvalidation statistical parameters. Statistically significant and physically meaningful models were obtained. The prediction results are very well correlated with the experimentally observed data. Given predictive ability of the established models indicates that they could be used for predicting the chromatographic behavior of the similar molecules in normal-phase high-performance thin-layer chromatography. [Projekat Ministarstva nauke Republike Srbije, br. 172012, br. 172014 i br. 31055