Impact of Vitamins and Minerals Enriched Flora in the Management of Calciphytoliths: A Special Focus on Vitamin E

Calciphytoliths (calcium oxalate calculi) have a great influence on human health and are a disease with a high likelihood of recurrence at a rate of more than 10% within a year. Plant flavonoids, saponins, and tannins are reported to be Litholytic by inhibiting calcium oxalate crystals or by their calcium channel blocking activity. Vitamins and minerals containing flora completely prevent deposition of oxalate by preventing pre-oxidation injury and restoring renal tissue antioxidants. So vitamin therapy also might protect against oxalate calculi deposition in the human kidneys. The present chapter discusses the impact of vitamins especially vitamin E, calcium, and low oxalate-containing plants for the management of various urinary or kidney disorders

In vitro antimitotic activity and in silico study of some 6-fluoro-triazolo-benzothiazole analogues

In this work, nine 6-fluoro-triazolo-benzothiazole derivatives were prepared and evaluated for in vitro antimitotic activity. In addition, in silico study was also done using tubulin protein (PDB: 6QQN) by molecular docking method. Results revealed that TZ2 and TZ9 were the most active compounds with antimitotic action opposing the standard drug, aspirin. Results of molecular docking exhibited the inhibitory potential of triazolo-benzothiazole against tubulin protein. The mitotic study indicates the efficacy of triazolo-benzothiazole analogues in inhibiting the proliferation of cancer cells either by promoting microtubule formation or affecting microtubules, thereby preventing microtubule breakdown

Medicinal Significance and Complications of Vitamin E

Vitamin E is a lipid-soluble substance that is the main component of the body’s defense system against free radicals. It performs a range of important functions in the body as a result of its antioxidant action. Cancer, aging, and other diseases and ailments have all been related to oxidation. It has been shown that vitamin E protects against rheumatoid arthritis and cataracts. Additionally, vitamin E can help to prevent the production of prostaglandins like thromboxane, which encourage platelet clustering and hyper aggregation, which can lead to atherosclerosis. The present literature review examines the roles and functions of vitamin E in human health, different disorders, and the consequences of vitamin E deficiency. The tocopherol family of vitamers is the focus of the review’s main points. In this review article, the part and actions of vitamin E are talked about, as well as the things that affect how well vitamin E treatment works. When given at the right time and for the right amount of time, Vitamin E should help people with oxidative stress caused by free radicals