A high intensity, high stability 3.5 MV Singletron™ accelerator

High Voltage Engineering has developed a high-current, light-ion 3.5 MV single-ended accelerator system to meet the stringent requirements on beam intensity and stability of the LUNA-MV project at Laboratori Nazionali del Gran Sasso (LNGS), L'Aquila, Italy. The accelerator has an all permanent magnet, 10 GHz ECR ion source to deliver intense beams of H (∼1 mA), He and C. The machine ensures energy stability below 10−5, terminal voltage ripple of 1.5 × 10−5 and uninterrupted operations time greater than 24 h as requested by LNGS. Various changes to the standard in-line Singletron accelerator were needed to satisfy these requirements. In this paper, we highlight design details about the accelerator and ECR source and present early performance results. © 2018 Elsevier B.V

Abstract 718: Reparative Macrophage Transplantation for Myocardial Repair: A Refinement of Bone Marrow Mononuclear Cell-Based Therapy

British Heart Foundation (Programme Grant RG/15/3/31236 and Project Grant PG/18/77/34100)Heart Research UK (Translational Research Grant; RG2618/12/13 and TRP06/15)Barts and The London School of Medicine and Dentistr

On-site fabrication of Bi-layered adhesive mesenchymal stromal cell-dressings for the treatment of heart failure.

Mesenchymal stromal/stem cell (MSC)-based therapy is a promising approach for the treatment of heart failure. However, current MSC-delivery methods result in poor donor cell engraftment, limiting the therapeutic efficacy. To address this issue, we introduce here a novel technique, epicardial placement of bi-layered, adhesive dressings incorporating MSCs (MSC-dressing), which can be easily fabricated from a fibrin sealant film and MSC suspension at the site of treatment. The inner layer of the MSC dressing, an MSC-fibrin complex, promptly and firmly adheres to the heart surface without sutures or extra glues. We revealed that fibrin improves the potential of integrated MSCs through amplifying their tissue-repair abilities and activating the Akt/PI3K self-protection pathway. Outer collagen-sheets protect the MSC-fibrin complex from abrasion by surrounding tissues and also facilitates easy handling. As such, the MSC-dressing technique not only improves initial retention and subsequent maintenance of donor MSCs but also augment MSC's reparative functions. As a result, this technique results in enhanced cardiac function recovery with improved myocardial tissue repair in a rat ischemic cardiomyopathy model, compared to the current method. Dose-dependent therapeutic effects by this therapy is also exhibited. This user-friendly, highly-effective bioengineering technique will contribute to future success of MSC-based therapy.British Heart Foundation, United Kingdom (Programme Grant RG/15/3/31236)Heart Research UK, United Kingdom (Translational Research Grant; RG2618/12/13 and TRP06/15)Heart Research UK, United Kingdom (Translational Research Grant; RG2618/12/13 and TRP06/15)Kaneka Corporatio