Dense and Sharp Resonance Peaks in Stretched Moir\'e Waveguides

In this article, we demonstrate dense resonant peaks in the transmission spectra of a rectangular waveguide inscribed with a stretched moir\'e pattern. We investigated an array of silicon waveguides with sinusoidally modulated cladding of varying depth of modulation. The investigation reveals a critical depth of modulation that splits the geometries into weakly scattering and strongly scattering regimes. Geometries in the weakly scattering regime resemble Bragg waveguides with shallow cladding modulation, whereas in the strongly scattering regime, the geometries resemble chains of isolated dielectric particles. The guided mode photonic bandgap for geometries in the strongly scattering regime is much larger than that of the weakly scattering regime. By inscribing stretched moir\'e patterns in the strongly scattering regime, we show that a large number of sharp peaks can be created in the transmission spectra of the waveguide. All periodic stretched moir\'e patterns can be identified with an R parameter. The R parameter indicates the ratio of the supercell period of the stretched system to the unstretched system. Our empirical study shows that the density of peaks linearly increases with R. The multiple resonance peaks evolve along well-defined trajectories with quality factor defined by exponential functions of R

Bilayer Metasurface: Induced Transparency and Fabry Perot Resonance

A Fabry-Perot resonator utilizes two solid, non-resonating, reflecting mirrors to form resonant patterns when the separation between the mirrors satisfies the resonance conditions. The resonant mode concentrates at the middle of the cavity. In this study, we constructed a Fabry-Perot cavity with nanostructured resonant metasurfaces as meta-mirrors. The individual metasurfaces exhibit resonant transmission dips with a minimum transmission and a quality factor of t0 and Qs, respectively. The coherent interference between the two metasurfaces changes the behavior of the entire resonant system, generating an induced transparency in the original spectrum. The sharpness of the induced transparency peak is linearly related to the group delay of the single metasurface. Assuming a Lorentzian lineshape, we show that for small t0, the quality factor of the induced transparency peak is Qs/t0^3. The field confines to the meta-mirrors region rather than at the middle of the Fabry-Perot cavity. We provide examples of practical metasurfaces made from dielectric scatters composed of silicon thin nanodisks and demonstrate high quality factors and phase dispersion that are unattainable by any nano or microscale flat optics systems

Photonic quasicrystal nanopatterned silicon thin film for photovoltaic applications

In this paper, the authors numerically studied the optical properties of a silicon photonic quasicrystal (PQC) nanohole array for photovoltaic applications. With the same active layer thickness, the ultimate efficiency of a solar cell integrated with an optimized PQC nanohole array can be enhanced by 9.01% and 1.40% compared to that with an ordered square lattice of a nanohole array and a random nanohole array, respectively. The absorptance enhancement is mainly due to the higher-order rotational symmetry in PQC structures, which leads to the presence of additional resonant modes, the broadening of existing modes and the reduction of surface reflectance. The angular response for both transverse-electric and transverse-magnetic modes are also analyzed in detail

Role of Linker Functionality in Polymers Exhibiting Main-Chain Thermally Activated Delayed Fluorescence

Excellent performance has been reported for organic light‐emitting diodes (OLEDs) based on small molecule emitters that exhibit thermally activated delayed fluorescence. However, the necessary vacuum processing makes the fabrication of large‐area devices based on these emitters cumbersome and expensive. Here, the authors present high performance OLEDs, based on novel, TADF polymers that can be readily processed from a solution. These polymers are based on the acridine‐benzophenone donor–acceptor motif as main‐chain TADF chromophores, linked by various conjugated and non‐conjugated spacer moieties. The authors’ extensive spectroscopic and electronic analysis shows that in particular in case of alkyl spacers, the properties and performance of the monomeric TADF chromophores are virtually left unaffected by the polymerization. They present efficient solution‐processed OLEDs based on these TADF polymers, diluted in oligostyrene as a host. The devices based on the alkyl spacer‐based TADF polymers exhibit external quantum efficiencies (EQEs) ≈12%, without any outcoupling‐enhancing measures. What's more, the EQE of these devices does not drop substantially upon diluting the polymer down to only ten weight percent of active material. In contrast, the EQE of devices based on the monomeric chromophore show significant losses upon dilution due to loss of charge percolation

Current and future economic burden of diabetes among working-age adults in Asia: conservative estimates for Singapore from 2010-2050

Abstract Background Diabetes not only imposes a huge health burden but also a large economic burden worldwide. In the working-age population, cost of lost productivity can far exceed diabetes-related medical cost. In this study, we aimed to estimate the current and future indirect and excess direct costs of diagnosed type 2 diabetes among the working-age population in Singapore. Methods A previously-published epidemiological model of diabetes was adapted to forecast prevalence among working-age patients with diagnosed type 2 diabetes in the absence of interventions. The current methodology of the American Diabetes Association was adopted to estimate the costs of diabetes for this population. Diabetes-related excess direct medical costs were obtained from a local cost study while indirect costs were calculated using the human capital approach applied to local labor force statistics. These cost were estimated conservatively from a societal perspective on a per patient basis and projected to the overall Singapore population from 2010 to 2050. Results In 2010, total economic costs per working-age patient were estimated to be US$5,646 (US$4,432-US$10,612), of which 42$7,791 (US$5,741-US$12,756) in 2050, with the share of indirect costs rising to 65 %. Simultaneous increases in prevalence imply that the total economic costs of diabetes for the entire working-age population will increase by 2.4 fold from US$787 million in 2010 to US$1,867 million in 2050. Conclusions By current projections, diabetes in Singapore represents a growing economic burden. Among the working-age population, the impact of productivity loss will become increasingly significant. Prevention efforts to reduce overall prevalence should also engage stakeholders outside the health sector who ultimately bear the indirect burden of disease

Variable alterations of the microbiota, without metabolic or immunological change, following faecal microbiota transplantation in patients with chronic pouchitis

© 2015 The Authors. Published by Springer Nature. This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.1038/srep12955Faecal microbiota transplantation (FMT) is effective in the treatment of Clostridium difficile infection, where efficacy correlates with changes in microbiota diversity and composition. The effects of FMT on recipient microbiota in inflammatory bowel diseases (IBD) remain unclear. We assessed the effects of FMT on microbiota composition and function, mucosal immune response, and clinical outcome in patients with chronic pouchitis. Eight patients with chronic pouchitis (current PDAI ‰7) were treated with FMT via nasogastric administration. Clinical activity was assessed before and four weeks following FMT. Faecal coliform antibiotic sensitivities were analysed, and changes in pouch faecal and mucosal microbiota assessed by 16S rRNA gene pyrosequencing and 1 H NMR spectroscopy. Lamina propria dendritic cell phenotype and cytokine profiles were assessed by flow cytometric analysis and multiplex assay. Following FMT, there were variable shifts in faecal and mucosal microbiota composition and, in some patients, changes in proportional abundance of species suggestive of a 'healthier' pouch microbiota. However, there were no significant FMT-induced metabolic or immunological changes, or beneficial clinical response. Given the lack of clinical response following FMT via a single nasogastric administration our results suggest that FMT/bacteriotherapy for pouchitis patients requires further optimisation.Published versio

Mitochondrial Dysfunction Links Ceramide Activated HRK Expression and Cell Death

Cell death is an essential process in normal development and homeostasis. In eyes, corneal epithelial injury leads to the death of cells in underlying stroma, an event believed to initiate corneal wound healing. The molecular basis of wound induced corneal stromal cell death is not understood in detail. Studies of others have indicated that ceramide may play significant role in stromal cell death following LASIK surgery. We have undertaken the present study to investigate the mechanism of death induced by C6 ceramide in cultures of human corneal stromal (HCSF) fibroblasts.Cultures of HCSF were established from freshly excised corneas. Cell death was induced in low passage (p<4) cultures of HCSF by treating the cells with C6 ceramide or C6 dihydroceramide as a control. Cell death was assessed by Live/Dead cell staining with calcein AM and ethidium homodimer-1 as well as Annexin V staining, caspase activation and TUNEL staining Mitochondrial dysfunction was assessed by Mito Sox Red, JC-1 and cytochrome C release Gene expression was examined by qPCR and western blotting.Our data demonstrate ceramide caused mitochondrial dysfunction as evident from reduced MTT staining, cyto c release from mitochondria, enhanced generation of ROS, and loss in mitochondrial membrane potential (ΔΨm). Cell death was evident from Live -Dead Cell staining and the inability to reestablish cultures from detached cells. Ceramide induced the expression of the harikari gene(HRK) and up-regulated JNK phosphorylation. In ceramide treated cells HRK was translocated to mitochondria, where it was found to interact with mitochondrial protein p32. The data also demonstrated HRK, p32 and BAD interaction. Ceramide-induced expression of HRK, mitochondrial dysfunction and cell death were reduced by HRK knockdown with HRK siRNA.Our data document that ceramide is capable of inducing death of corneal stromal fibroblasts through the induction of HRK mediated mitochondria dysfunction