The Essence of E-Commerce in Terms of the Global Economy

The article is aimed at researching the essence of e-trade as a combination of economic relations between entities of different national economies on the exchange, distribution and redistribution of benefits by means of computer technologies as an instrument of information exchange in the global economy. The article analyzes essence of e-commerce and its features; factors influencing its development; data emerging from the use of global information technologies and electronic networks; formation of new forms of public relations between producers, intermediaries and consumers of goods and services in the international market. The topicality of research of the essence of e-trade and electronic methods of doing business is substantiated. The identity of e-commerce with trade via Internet is defined; five main channels (instruments) of implementation are allocated; it is recommended to enterprises around the world to change ways of organizing and managing their business, abandon the old hierarchical structure. E-commerce is classified in terms of the composition of its participants (entities), entering a new level of relations between the consumer and the supplier is suggested, and it is recommended to advance the UNCTAD’s weeks on e-commerce

Detection and defect correction of operating process

The article is devoted to the current problem of enterprise competitiveness rise in hard and competitive terms of business environment. The importance of modern equipment for detection of defects and their correction is explained. Production of chipboard is used as an object of research. Short description and main results of estimation efficiency of innovative solutions of enterprises are considered

A fluorescent microspheres-based microfluidic test system for the detection of immunoglobulin G to SARS-CoV-2

Background: The pandemic of the new coronavirus infection, COVID-19, is currently ongoing in the world. Over the years, the pathogen, SARS-CoV-2, has undergone a series of mutational genome changes, which has led to the spread of various genetic variants of the virus. Meanwhile, the methods used to diagnose SARS-CoV-2, to establish the disease stage and to assess the immunity, are nonspecific to SARS-CoV-2 variants and time-consumable. Thus, the development of new methods for diagnosing COVID-19, as well as their implementation in practice, is currently an important direction. In particular, application of systems based on chemically modified fluorescent microspheres (with a multiplex assay for target protein molecules) opens great opportunities. Aim: development of a microfluidic diagnostic test system based on fluorescent microspheres for the specific detection of immunoglobulins G (IgG) to SARS-CoV-2. Methods: A collection of human serum samples was characterized using enzyme-linked immunosorbent assay (ELISA) and commercially available reagent kits. IgG to SARS-CoV-2 in the human serum were detected by the developed immunofluorescent method using microspheres containing the chemically immobilized RBD fragment of the SARS-CoV-2 (Kappa variant) viral S-protein. Results: The level of IgG in the blood serum of recovered volunteers was 9-300 times higher than that in apparently healthy volunteers, according to ELISA (p0.001). Conjugates of fluorescent microspheres with the RBD-fragment of the S-protein, capable of specifically binding IgG from the blood serum, have been obtained. The immune complexes formation was confirmed by the fluorescence microscopy data; the fluorescence intensity of secondary antibodies in the immune complexes formed on the surface of microspheres was proportional to the content of IgG (r 0.963). The test system had a good predictive value (AUC 70.3%). Conclusion: A test system has been developed, based on fluorescent microspheres containing the immobilized RBD fragment of the SARS-CoV-2 S-protein, for the immunofluorescent detection of IgG in the human blood serum. When testing the system on samples with different levels of IgG to SARS-CoV-2, its prognostic value was shown. The obtained results allow us to present the test system as a method to assess the level of immunoglobulins to SARS-CoV-2 in the human blood serum for the implementation in clinical practice. The test system can also be integrated into various microfluidic systems to create chips and devices for the point-of-care diagnostics

Pedagogical means of students training in conditions of agricultural complex digitalization

The actual problem, and simultaneously, the trend of today’s vocational – education digitalization of agricultural experts training in Russia are investigated. The review of the theory of the question, which proves the idea of accord of vocational training digitalization process of the XXI century tasks, is made. Didactic digitalization elements as a process are correlated with the revealed professional agricultural engineering problems. Digitalization maintenances opportunities of science subjects as possible means of the priority purposes achievement of modern vocational trainings are investigated. The substantiation of the projected course «Methods of optimum decisions acceptance» as a set of the competence-focused modules is achieved, each of which corresponded to concrete type of optimization problems, solved by agroengineers in professional work

Prospects for the use of microwave energy in grain crop seeding

This study looks at determining the main trends in the application of microwaves on plants in agricultural production in the processing of grain material, it provides examples of their effectiveness and an overview of the use of microwaves on plants available on the Russian market. Additionally, the research studied the experience and developments of leading scientists in the field of microwave radiation. Analysis of the available sources provided information on the positive effect of microwave radiation in the processing of crops. The use of microwaves on plants during drying destroys pathogens and bacteria, in particular, microwave processing of red lentils reduces grey mould damage by up to 30%. Positive results are also noted in the microwave processing of other crops, providing an increase in germination capacity of up to 7% and yield growth of up to 6%. The microwave plant market in Russia is represented mainly by dryers, and the use of microwaves on plants combining several functions of drying, disinfection, and pre-sowing stimulation

Post-anaesthesia pulmonary complications after use of muscle relaxants (POPULAR): a multicentre, prospective observational study

Background Results from retrospective studies suggest that use of neuromuscular blocking agents during general anaesthesia might be linked to postoperative pulmonary complications. We therefore aimed to assess whether the use of neuromuscular blocking agents is associated with postoperative pulmonary complications. Methods We did a multicentre, prospective observational cohort study. Patients were recruited from 211 hospitals in 28 European countries. We included patients (aged ≥18 years) who received general anaesthesia for any in-hospital procedure except cardiac surgery. Patient characteristics, surgical and anaesthetic details, and chart review at discharge were prospectively collected over 2 weeks. Additionally, each patient underwent postoperative physical examination within 3 days of surgery to check for adverse pulmonary events. The study outcome was the incidence of postoperative pulmonary complications from the end of surgery up to postoperative day 28. Logistic regression analyses were adjusted for surgical factors and patients’ preoperative physical status, providing adjusted odds ratios (ORadj) and adjusted absolute risk reduction (ARRadj). This study is registered with ClinicalTrials.gov, number NCT01865513. Findings Between June 16, 2014, and April 29, 2015, data from 22803 patients were collected. The use of neuromuscular blocking agents was associated with an increased incidence of postoperative pulmonary complications in patients who had undergone general anaesthesia (1658 [7·6%] of 21694); ORadj 1·86, 95% CI 1·53–2·26; ARRadj –4·4%, 95% CI –5·5 to –3·2). Only 2·3% of high-risk surgical patients and those with adverse respiratory profiles were anaesthetised without neuromuscular blocking agents. The use of neuromuscular monitoring (ORadj 1·31, 95% CI 1·15–1·49; ARRadj –2·6%, 95% CI –3·9 to –1·4) and the administration of reversal agents (1·23, 1·07–1·41; –1·9%, –3·2 to –0·7) were not associated with a decreased risk of postoperative pulmonary complications. Neither the choice of sugammadex instead of neostigmine for reversal (ORadj 1·03, 95% CI 0·85–1·25; ARRadj –0·3%, 95% CI –2·4 to 1·5) nor extubation at a train-of-four ratio of 0·9 or more (1·03, 0·82–1·31; –0·4%, –3·5 to 2·2) was associated with better pulmonary outcomes. Interpretation We showed that the use of neuromuscular blocking drugs in general anaesthesia is associated with an increased risk of postoperative pulmonary complications. Anaesthetists must balance the potential benefits of neuromuscular blockade against the increased risk of postoperative pulmonary complications