Разработка мультиметодологического подхода к биопсии рака

Considering recent advances in the field of cancer diagnostics, the authors, researcher

Bilateral vestibulopathy and age:experimental considerations for testing dynamic visual acuity on a treadmill

Introduction: Bilateral vestibulopathy (BVP) can affect visual acuity in dynamic conditions, like walking. This can be assessed by testing Dynamic Visual Acuity (DVA) on a treadmill at different walking speeds. Apart from BVP, age itself might influence DVA and the ability to complete the test. The objective of this study was to investigate whether DVA tested while walking, and the drop-out rate (the inability to complete all walking speeds of the test) are significantly influenced by age in BVP-patients and healthy subjects. Methods: Forty-four BVP-patients (20 male, mean age 59 years) and 63 healthy subjects (27 male, mean age 46 years) performed the DVA test on a treadmill at 0 (static condition), 2, 4 and 6 km/h (dynamic conditions). The dynamic visual acuity loss was calculated as the difference between visual acuity in the static condition and visual acuity in each walking condition. The dependency of the drop-out rate and dynamic visual acuity loss on BVP and age was investigated at all walking speeds, as well as the dependency of dynamic visual acuity loss on speed. Results: Age and BVP significantly increased the drop-out rate (p ≤ 0.038). A significantly higher dynamic visual acuity loss was found at all speeds in BVP-patients compared to healthy subjects (p < 0.001). Age showed no effect on dynamic visual acuity loss in both groups. In BVP-patients, increasing walking speeds resulted in higher dynamic visual acuity loss (p ≤ 0.036). Conclusion DVA tested while walking on a treadmill, is one of the few “close to reality” functional outcome measures of vestibular function in the vertical plane. It is able to demonstrate significant loss of DVA in bilateral vestibulopathy patients. However, since bilateral vestibulopathy and age significantly increase the drop-out rate at faster walking speeds, it is recommended to use age-matched controls. Furthermore, it could be considered to use an individual “preferred” walking speed and to limit maximum walking speed in older subjects when testing DVA on a treadmill

Дисфункция эндотелия у пациентов с различными формами врожденного буллезного эпидермолиза

Introduction. The endothelial system is an important component of vascular-platelet hemostasis, capable of actively responding to mechanical and inflammatory agents. Patients with congenital epidermolysis bullosa are prone to mechanical damage to the skin and the development of a chronic inflammatory syndrome with a high probability of endothelial dysfunction.The study objective was to assess the state of the endothelial system and to reveal the dependence of endothelial dysfunction on the form of epidermolysis bullosa.Methods and materials. The study used venous blood of 57 patients (27 men and 30 women) with congenital epidermolysis bullosa. In patients with simple and dystrophic forms of epidermolysis bullosa, the platelet count, P-selectin, fibrinogen, albumin, C-reactive protein, von Willebrand factor antigen concentration, and factor VIII activity were determined.Results. Comparative results of endothelial dysfunction depending on the form of epidermolysis bullosa were represented and endothelial dysfunction’s dependence on the concentration of albumin, C-reactive protein, and platelet count was determined.Conclusions. In patients with a dystrophic form of epidermolysis bullosa, endothelial dysfunction is accompanied by an increase in the expression of P-selectin, factor VIII activity, and the concentration of von Willebrand factor antigen. Chronic inflammation and impaired nutritional status with a decrease in albumin contribute to the development of endothelial dysfunction. Введение. Эндотелиальная система – важный компонент сосудисто-тромбоцитарного гемостаза, способная активно реагировать на механические и воспалительные агенты. Пациенты с врожденным буллезным эпидермолизом подвержены механическому повреждению кожных покровов и развитию хронического воспалительного синдрома с высокой вероятностью развития дисфункции эндотелия. Цель исследования–оценить состояние эндотелиальной системы и выявить зависимость дисфункции эндотелия от формы буллезного эпидермолиза.Методы и материалы. В исследовании использовали венозную кровь 57 пациентов (27 мужчин и 30 женщин) с врожденным буллезным эпидермолизом. У пациентов с простой и дистрофической формами буллезного эпидермолиза определяли количество тромбоцитов, P-селектин, фибриноген, альбумин, С-реактивный белок, концентрацию антигена фактора Виллебранда и активность фактора VIII.Результаты. Представлены сравнительные результаты дисфункции эндотелия в зависимости от формы буллезного эпидермолиза и определена зависимость дисфункции эндотелия от концентрации альбумина, С-реактивного белка и количества тромбоцитов.Заключение. У пациентов с дистрофической формой буллезного эпидермолиза дисфункция эндотелия сопровождается повышением экспрессии P-селектина, активности фактора VIII и концентрации антигена фактора Виллебранда. Хроническое воспаление и нарушение нутритивного статуса со снижением альбумина способствуют развитию дисфункции эндотелия.

Diagnosing vestibular hypofunction: an update

Unilateral or bilateral vestibular hypofunction presents most commonly with symptoms of dizziness or postural imbalance and affects a large population. However, it is often missed because no quantitative testing of vestibular function is performed, or misdiagnosed due to a lack of standardization of vestibular testing. Therefore, this article reviews the current status of the most frequently used vestibular tests for canal and otolith function. This information can also be used to reach a consensus about the systematic diagnosis of vestibular hypofunction

Разработка мультиметодологического подхода к биопсии рака

Considering recent advances in the field of cancer diagnostics, the authors, researcher

THE WAYS AND METHODS OF MAINTENANCE OF ECONOMIC STABILITY OF BUILDING ENTERPRISE BY CAUSE OF DYNAMIC MODEL

It is considered in work what exactly is main base for construction of dynamic model of stability of the building enterprise. There are submitted normative requirements which provide economic stability and also normative parities of dynamics of the parameters that correspond to these requirements. The technique of providing of economic stability is submitted on examples of two building enterprises of Ekaterinburg in view of results of their work in years of 2005-2006. There are determined the ways of providing of economic stability on the results of the carried out calculation. There are also revealed reserves of the enterprises for growth of efficiency of their activity

Modern Methods of Both Stability Management and Effective Performance of Building Enterprise

The set of factors of economic stability estimation of building enterprise in particular the regress equation by Edvard I. Altman are given. The standard approach to an estimation of economic stability when the functioning of enterprise is defined as the consecutive circuit of its conditions in time is presented. The operating enterprise model as boundary points of target areas and allowable trajectories of system functioning are classified.В работе приводится ряд критериев оценки экономической устойчивости строительного предприятия, в частности, уравнение регрессии Эдварда И. Альтмана. Рассматривается общепринятый подход к оценке экономической устойчивости, при котором функционирование предприятия определяется как последовательная схема его состояний во времени. Анализируется динамика устойчивости производственной системы. Классифицируются режимы работы предприятия как граничные точки областей целевых и допустимых траекторий функционирования системы