Quasiexcitons in Incompressible Quantum Liquids

Photoluminescence (PL) has been used to study two-dimensional incompressible electron liquids in high magnetic fields for nearly two decades. However, some of the observed anomalies coincident with the fractional quantum Hall effect are still unexplained. We show that emission in these systems occurs from fractionally charged "quasiexciton" states formed from trions correlated with the surrounding electrons. Their binding and recombination depend on the state of both the electron liquid and the involved trion, predicting discontinuities in PL and sensitivity to sample parameters.Comment: 4 pages, 4 figure

Multicrystalline silicon thin-film solar cells based on vanadium oxide heterojunction and laser-doped contacts

This is the peer reviewed version of the following article: Martín, I., López, G., Plentz, J., Jin, C., Ortega, P., Voz, C., Puigdollers, J., Gawlik, A., Jia, G. and Andrä, G. (2019), Multicrystalline Silicon Thin‐Film Solar Cells Based on Vanadium Oxide Heterojunction and Laser‐Doped Contacts. Phys. Status Solidi A, 216: 1900393, which has been published in final form at https://doi.org/10.1002/pssa.201900393. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.Liquid phase crystallized (LPC) silicon thin films on glass substrates are a feasible alternative to conventional crystalline silicon (c-Si) wafers for solar cells. Due to substrate limitation, a low-temperature technology is needed for solar cell fabrication. While silicon heterojunction is typically used, herein, the combination of vanadium oxide/c-Si heterojunction as emitter and base contacts defined by IR laser processing of phosphorus-doped amorphous silicon carbide stacks is explored. LPC solar cells are fabricated using such technologies to identify their issues and advantages with a promising performance of an active-area efficiency of 5.6%. Apart from the absence of light-trapping techniques, the relatively low efficiency obtained is attributed to a low lifetime in the LPC silicon bulk. These poor material properties imply a short diffusion length that makes it that only photogenerated carriers in the emitter regions can be collected. Consequently, future devices should show narrower base contact regions, suggesting a shorter-wavelength laser, combined with longer LPC substrate lifetimes.Peer ReviewedPostprint (author's final draft

Charged exctions in the fractional quantum Hall regime

We study the photoluminescence spectrum of a low density ($\nu <1$) two-dimensional electron gas at high magnetic fields and low temperatures. We find that the spectrum in the fractional quantum Hall regime can be understood in terms of singlet and triplet charged-excitons. We show that these spectral lines are sensitive probes for the electrons compressibility. We identify the dark triplet charged-exciton and show that it is visible at the spectrum at $T<2$ K. We find that its binding energy scales like $e^{2}/l$, where $l$ is the magnetic length, and it crosses the singlet slightly above 15 T.Comment: 10 pages, 5 figure

Skyrmionic excitons

We investigate the properties of a Skyrmionic exciton consisting of a negatively charged Skyrmion bound to a mobile valence hole. A variational wave function is constructed which has the generalized total momentum P as a good quantum number. It is shown that the Skyrmionic exciton can have a larger binding energy than an ordinary magnetoexciton and should therefore dominate the photoluminescence spectrum in high-mobility quantum wells and heterojunctions where the electron-hole separation exceeds a critical value. The dispersion relation for the Skyrmionic exciton is discussed.Comment: 9 pages, RevTex, 2 PostScript figures. Replaced with version to appear in Phys. Rev. B Rapid Communications. Short discussion of variational state adde

Theory of Photoluminescence of the ν=1\nu=1 Quantum Hall State: Excitons, Spin-Waves and Spin-Textures

We study the theory of intrinsic photoluminescence of two-dimensional electron systems in the vicinity of the $\nu=1$ quantum Hall state. We focus predominantly on the recombination of a band of initial ``excitonic states'' that are the low-lying energy states of our model at $\nu=1$. It is shown that the recombination of excitonic states can account for recent observations of the polarization-resolved spectra of a high-mobility GaAs quantum well. The asymmetric broadening of the spectral line in the $\sigma_-$ polarization is explained to be the result of the ``shake-up'' of spin-waves upon radiative recombination of excitonic states. We derive line shapes for the recombination of excitonic states in the presence of long-range disorder that compare favourably with the experimental observations. We also discuss the stabilities and recombination spectra of other (``charged'') initial states of our model. An additional high-energy line observed in experiment is shown to be consistent with the recombination of a positively-charged state. The recombination spectrum of a negatively-charged initial state, predicted by our model but not observed in the present experiments, is shown to provide a direct measure of the formation energy of the smallest ``charged spin-texture'' of the $\nu=1$ state.Comment: 23 pages, 7 postscript figures included. Revtex with epsf.tex and multicol.sty. The revised version contains slightly improved numerical results and a few additional discussions of the result

Long-lived charged multiple-exciton complexes in strong magnetic fields

We consider the charged exciton complexes of an ideal two-dimensional electron-hole system in the limit of strong magnetic fields. A series of charged multiple-exciton states is identified and variational and finite-size exact diagonalization calculations are used to estimate their binding energies. We find that, because of a hidden symmetry, bound states of excitons and an additional electron cannot be created by direct optical absorption and, once created, have an infinite optical recombination lifetime. We also estimate the optical recombination rates when electron and hole layers are displaced and the hidden symmetry is violated.Comment: 12 pages + 2 PostScript figures, Revtex, Submitted to Phys. Rev. Let

A multi-gene signature predicts outcome in patients with pancreatic ductal adenocarcinoma.

© 2014 Haider et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.Improved usage of the repertoires of pancreatic ductal adenocarcinoma (PDAC) profiles is crucially needed to guide the development of predictive and prognostic tools that could inform the selection of treatment options

Muscle Phenotypic Variability in Limb Girdle Muscular Dystrophy 2 G

Abstract Limb girdle muscular dystrophy type 2 G (LGMD2G) is caused by mutations in the telethonin gene. Only few families were described presenting this disease, and they are mainly Brazilians. Here, we identified one additional case carrying the same common c.157C &gt; T mutation in the telethonin gene but with an atypical histopathological muscle pattern. In a female patient with a long duration of symptoms (46 years), muscle biopsy showed, in addition to telethonin deficiency, the presence of nemaline rods, type 1 fiber predominance, nuclear internalization, lobulated fibers, and mitochondrial paracrystalline inclusions. Her first clinical signs were identified at 8 years old, which include tiptoe walking, left lower limb deformity, and frequent falls. Ambulation loss occurred at 41 years old, and now, at 54 years old, she presented pelvic girdle atrophy, winging scapula, foot deformity with incapacity to perform ankle dorsiflexion, and absent tendon reflexes. The presence of nemaline bodies could be a secondary phenomenon, possibly associated with focal Z-line abnormalities of a long-standing disease. However, these new histopathological findings, characteristic of congenital myopathies, expand muscle phenotypic variability of telethoninopathy

Gamma secretase inhibition promotes hypoxic necrosis in mouse pancreatic ductal adenocarcinoma.

Pancreatic ductal adenocarcinoma (PDA) is a highly lethal disease that is refractory to medical intervention. Notch pathway antagonism has been shown to prevent pancreatic preneoplasia progression in mouse models, but potential benefits in the setting of an established PDA tumor have not been established. We demonstrate that the gamma secretase inhibitor MRK003 effectively inhibits intratumoral Notch signaling in the KPC mouse model of advanced PDA. Although MRK003 monotherapy fails to extend the lifespan of KPC mice, the combination of MRK003 with the chemotherapeutic gemcitabine prolongs survival. Combination treatment kills tumor endothelial cells and synergistically promotes widespread hypoxic necrosis. These results indicate that the paucivascular nature of PDA can be exploited as a therapeutic vulnerability, and the dual targeting of the tumor endothelium and neoplastic cells by gamma secretase inhibition constitutes a rationale for clinical translation

A phase I study of the oral gamma secretase inhibitor R04929097 in combination with gemcitabine in patients with advanced solid tumors (PHL-078/CTEP 8575)

PURPOSE: To establish the recommended phase II dose of the oral γ-secretase inhibitor RO4929097 (RO) in combination with gemcitabine; secondary objectives include the evaluation of safety, tolerability, pharmacokinetics, biomarkers of Notch signaling and preliminary anti-tumor activity. METHODS: Patients with advanced solid tumors were enrolled in cohorts of escalating RO dose levels (DLs). Tested RO DLs were 20 mg, 30 mg, 45 mg and 90 mg. RO was administered orally, once daily on days 1-3, 8-10, 15-17, 22-24. Gemcitabine was administered at 1,000 mg/m(2) on d1, 8, and 15 in 28 d cycles. Dose limiting toxicities (DLTs) were assessed by CTCAE v4. Serial plasma was collected for RO (total and unbound) and gemcitabine pharmacokinetic analysis. Biomarkers of Notch signaling were assessed by immunohistochemistry in archival tissue. Antitumor activity was evaluated (RECIST 1.1). RESULTS: A total of 18 patients were enrolled to establish the recommended phase II dose. Of these, 3 patients received 20 mg RO, 7 patients received 30 mg RO, 6 patients received 45 mg RO and 2 patients received 90 mg RO. DLTs were grade 3 transaminitis (30 mg RO), grade 3 transaminitis and maculopapular rash (45 mg RO), and grade 3 transaminitis and failure to receive 75 % of planned RO doses secondary to prolonged neutropenia (90 mg); all were reversible. The maximum tolerated dose was exceeded at 90 mg RO. Pharmacokinetic analysis of both total and free RO confirmed the presence of autoinduction at 45 and 90 mg. Median levels of Notch3 staining were higher in individuals who received fewer than 4 cycles (p = 0.029). Circulating angiogenic factor levels did not correlate with time to progression or ≥ grade 3 adverse events. Best response (RECIST 1.1) was partial response (nasopharyngeal cancer) and stable disease > 4 months was observed in 3 patients (pancreas, tracheal, and breast primary cancers). CONCLUSIONS: RO and gemcitabine can be safely combined. The recommended phase II dose of RO was 30 mg in combination with gemcitabine 1,000 mg/m(2). Although RO exposure was limited by the presence of autoinduction, RO levels achieved exceeded the area under the concentration-time curve for 0-24 h (AUC(0-24)) predicted for efficacy in preclinical models using daily dosing. Evidence of clinical antitumor activity and prolonged stable disease were identified