Agent-based agreement over concept meaning using contrast sets

We develop a model for 2 agents to reach agreement over concept meaning in specific contexts. The model is based on an argumentation-based communication that engage the agents in a process of mutual adaptation using argumentation to reach an agreement over concept meaning. Our approach is to model concept meaning using the semiotic triangle and the notion of contrast sets. We implement and evaluate present three common sense scenarios where two agents argue and reach agreements over the contextual meaning of concepts. © 2015 The authors and IOS Press. All rights reservedThis paper has been partially supported by projects ESSENCE: Evolution of Shared Semantics in Computational Environments (TIN 607062) and NASAID (CSIC Intramural 201550E022)Peer Reviewe

GPU-friendly neural networks for remote sensing scene classification

Convolutional neural networks (CNNs) have proven to be very efficient for the analysis of remote sensing (RS) images. Due to the inherent complexity of extracting features from these images, along with the increasing amount of data to be processed (and the diversity of applications), there is a clear tendency to develop and employ increasingly deep and complex CNNs. In this regard, graphics processing units (GPUs) are frequently used to optimize their execution, both for the training and inference stages, optimizing the performance of neural models through their many-core architecture. Hence, the efficient use of the GPU resources should be at the core of optimizations. This letter analyzes the possibilities of using a new family of CNNs, denoted as TResNets, to provide an efficient solution to the RS scene classification problem. Moreover, the considered models have been combined with mixed precision to enhance their training performance. Our experimental results, conducted over three publicly available RS data sets, show that the proposed networks achieve better accuracy and more efficient use of GPU resources than other state-of-the-art networks. Source code is available at https://github.com/mhaut/GPUfriendlyRS

Influence of extremophiles on the generation of acid mine drainage at the abandoned pan de azúcar mine (Argentina)

The risk of generation of acid drainages in the tailings of the Pan de Azúcar mine that closed its activities more than three decades ago, was evaluated through biooxidation studies using iron-and sulfur-oxidizing extremophilic leaching consortia. Most of tailings showed a high potential for generating acid drainage, in agreement with the results from net acid generation (NAG) assays. In addition, molecular analysis of the microbial consortia obtained by enrichment of the samples, demonstrated that native leaching microorganisms are ubiquitous in the area and they seemed to be more efficient in the biooxidation of the tailings than the collection microorganisms. The acid drainages detected at the site and those formed by oxidation of the tailings, produced a significant ecotoxicological effect demonstrated by a bioassay. These drainages, even at high dilutions, could seriously affect a nearby Ramsar site (Laguna de Pozuelos) that is connected to the Pan de Azúcar mine through a hydrological route (Cincel River).Fil: Plaza Cazón, Josefina del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Fermentaciones Industriales. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Fermentaciones Industriales; ArgentinaFil: Benitez, Leonardo Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Fermentaciones Industriales. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Fermentaciones Industriales; ArgentinaFil: Murray, Jesica María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Bio y Geociencias del NOA. Universidad Nacional de Salta. Facultad de Ciencias Naturales. Museo de Ciencias Naturales. Instituto de Bio y Geociencias del NOA; ArgentinaFil: Kirschbaum, Pablo Enrique. Universidad Nacional de Salta. Facultad de Cs.naturales. Carrera de Geología; ArgentinaFil: Donati, Edgardo Ruben. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Fermentaciones Industriales. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Fermentaciones Industriales; Argentin

Inflammatory markers and bone mass in children with overweight/obesity: the role of muscular fitness

Objectives To examine which inflammatory markers are associated with bone mass and whether this association varies according to muscular fitness in children with overweight/obesity. Methods Plasma interleukin-1β (IL-1β), IL-6, tumor necrosis factor-α (TNF-α), epidermal growth factor, vascular endothelial growth factor A (VEGF), and C-reactive protein were analyzed in 55 children aged 8–11 years. A muscular fitness score was computed. Bone mineral content (BMC) of the total body-less head (TBLH) and lumbar spine (LS) were assessed using dual-energy x-ray absorptiometry. Results IL-6 (β = −0.136) and VEGF (β = −0.099) were associated with TBLH BMC, while TNF-α (β = −0.345) and IL-1β (β = 0.212) were associated with LS BMC (P < 0.05). The interaction effect of muscular fitness showed a trend in the association of VEGF with TBLH BMC (P = 0.122) and TNF-α with LS BMC (P = 0.057). Stratified analyses by muscular fitness levels showed an inverse association of VEGF with TBLH BMC (β = −0.152) and TNF-α with LS BMC (β = −0.491) in the low-fitness group, while no association was found in the high-fitness group. Conclusion IL-6, VEGF, TNF-α, and IL-1β are significantly associated with bone mass. Higher muscular fitness may attenuate the adverse effect of high VEGF and TNF-α on bone mass

Trabajo final Diplomado de Profundizacion en farmacovigilancia

se ingresan in diagrama y una imagenLa farmacovigilancia es el estudio de las interacciones adversas de identificación, cuantificación, evaluación y prevención de los riesgos, siguiendo una norma de leyes y protocolos en la calificación del bien común como personas de una vida saludable y sin complicaciones. Como bien todos conocemos el proceso que este representa en su calidad de vida, su mejor trasformación de conocimiento esencial a cada medicamento que este sea dispensado en cualquier ente de salud o que esté acorde al ente farmacéutico, el regente de farmacia debe hacer cumplir su papel con una buena calidad de vida en su proceso de seguridad en la farmacovigilancia , siempre procurar ser cada día mejor en lo que hagamos , sentirnos orgullosos y hacer el bien común a nuestros seres humanos , cuidándolos , respetándolos y velar por nuestra seguridad y la de ellos mismos .Pharmacovigilance is the study of adverse interactions of identification, quantification, evaluation and prevention of risks, following a standard of laws and protocols in the qualification of the common good as people with a healthy life and without complications. As we all know well the process that this represents in their quality of life, its best transformation of essential knowledge to each drug that is dispensed in any health entity or that is in accordance with the pharmaceutical entity, the pharmacy manager must enforce its role with a good quality of life in its safety process in pharmacovigilance, always strive to be better every 8day in what we do, feel proud and do the common good to our human beings, taking care of them, respecting them and ensuring our safety and theirs themselves

Sexual dimorphism in the antitumor immune responses elicited by the combination of fasting and chemotherapy

descripción no proporcionada por scopusAEI/10.13039/501100011033/Ministerio de Ciencia e Innovación FPU19/02576/Ministerio de Ciencia e Innovación FPU20/04066/Ministerio de Ciencia e Innovación PID 2019-104012RB-I00/Ministerio de Ciencia e Innovación PID2020-114077RB-I00/Ministerio de Ciencia e Innovació

The search for the maximum 2d-particle size that can be internalized by living cells

4 p.Peer reviewe

Distribución anatómica de ramas subendocárdicas en mamífero no humano, primer reporte

Establecer la organización de las fibras subendocárdicas es útil para determinar la conducción y propagación normal o anormal del impulso cardiaco y tiene trascendencia en el campo educativo, hemodinámico y cardiológico; su identificación ha sido posible habiéndose encontrado patrones similares en muchas especies mamíferas.&nbsp; Históricamente denominadas fibras de Purkinje, las ramas subendocárdicas (A.12.1.06.008) de Terminologia Anatomica son inidentificadas macroscópicamente y han sido evidenciadas con varias técnicas con distinto valor y limitaciones. Como componente de la formación académica, en el laboratorio de Anatomía Humana de la Universidad de Guayaquil&nbsp; se ha replicado su identificación utilizando tinta china en corazones adultos de vacunos y porcinos frescos mostrándose macroscópica e histológicamente su presencia. El nodo sinoatrial y atrioventricular son uniformes en su constitución, las fibras subendocárdicas muestran una estructura reticular con múltiples interconexiones, esto ha permitido realizar una descripción aproximada. Sus detalles de distribución y organización son importantes para interpretar los problemas de conducción como las arritmias

Long-term outcomes of the global tuberculosis and COVID-19 co-infection cohort

Background: Longitudinal cohort data of patients with tuberculosis (TB) and coronavirus disease 2019 (COVID-19) are lacking. In our global study, we describe long-term outcomes of patients affected by TB and COVID-19. Methods: We collected data from 174 centres in 31 countries on all patients affected by COVID-19 and TB between 1 March 2020 and 30 September 2022. Patients were followed-up until cure, death or end of cohort time. All patients had TB and COVID-19; for analysis purposes, deaths were attributed to TB, COVID-19 or both. Survival analysis was performed using Cox proportional risk-regression models, and the log-rank test was used to compare survival and mortality attributed to TB, COVID-19 or both. Results: Overall, 788 patients with COVID-19 and TB (active or sequelae) were recruited from 31 countries, and 10.8% (n=85) died during the observation period. Survival was significantly lower among patients whose death was attributed to TB and COVID-19 versus those dying because of either TB or COVID-19 alone (p&lt;0.001). Significant adjusted risk factors for TB mortality were higher age (hazard ratio (HR) 1.05, 95% CI 1.03-1.07), HIV infection (HR 2.29, 95% CI 1.02-5.16) and invasive ventilation (HR 4.28, 95% CI 2.34-7.83). For COVID-19 mortality, the adjusted risks were higher age (HR 1.03, 95% CI 1.02-1.04), male sex (HR 2.21, 95% CI 1.24-3.91), oxygen requirement (HR 7.93, 95% CI 3.44-18.26) and invasive ventilation (HR 2.19, 95% CI 1.36-3.53). Conclusions: In our global cohort, death was the outcome in &gt;10% of patients with TB and COVID-19. A range of demographic and clinical predictors are associated with adverse outcomes

Association between convalescent plasma treatment and mortality in COVID-19: a collaborative systematic review and meta-analysis of randomized clinical trials.

Funder: laura and john arnold foundationBACKGROUND: Convalescent plasma has been widely used to treat COVID-19 and is under investigation in numerous randomized clinical trials, but results are publicly available only for a small number of trials. The objective of this study was to assess the benefits of convalescent plasma treatment compared to placebo or no treatment and all-cause mortality in patients with COVID-19, using data from all available randomized clinical trials, including unpublished and ongoing trials (Open Science Framework, https://doi.org/10.17605/OSF.IO/GEHFX ). METHODS: In this collaborative systematic review and meta-analysis, clinical trial registries (ClinicalTrials.gov, WHO International Clinical Trials Registry Platform), the Cochrane COVID-19 register, the LOVE database, and PubMed were searched until April 8, 2021. Investigators of trials registered by March 1, 2021, without published results were contacted via email. Eligible were ongoing, discontinued and completed randomized clinical trials that compared convalescent plasma with placebo or no treatment in COVID-19 patients, regardless of setting or treatment schedule. Aggregated mortality data were extracted from publications or provided by investigators of unpublished trials and combined using the Hartung-Knapp-Sidik-Jonkman random effects model. We investigated the contribution of unpublished trials to the overall evidence. RESULTS: A total of 16,477 patients were included in 33 trials (20 unpublished with 3190 patients, 13 published with 13,287 patients). 32 trials enrolled only hospitalized patients (including 3 with only intensive care unit patients). Risk of bias was low for 29/33 trials. Of 8495 patients who received convalescent plasma, 1997 died (23%), and of 7982 control patients, 1952 died (24%). The combined risk ratio for all-cause mortality was 0.97 (95% confidence interval: 0.92; 1.02) with between-study heterogeneity not beyond chance (I2 = 0%). The RECOVERY trial had 69.8% and the unpublished evidence 25.3% of the weight in the meta-analysis. CONCLUSIONS: Convalescent plasma treatment of patients with COVID-19 did not reduce all-cause mortality. These results provide strong evidence that convalescent plasma treatment for patients with COVID-19 should not be used outside of randomized trials. Evidence synthesis from collaborations among trial investigators can inform both evidence generation and evidence application in patient care