Examination of rheological properties of fine particle dispersions as carriers for controlled drug release

The rheological characteristics of various systems made by mixing blood, blood serum, and drug carriers, as liposomes, lipid emulsion and polymer latex (model system for nano- particles) are reported as function of shear rate and volume fraction of solid. The diversity of system behaviour (pseudoplasticity, dilatancy and tixotropy), is detected: some are Newtonian and some non-Newtonian. Attention is directed especially to viscosity of the systems developing theoretical models to forecast drug carrier behaviour under different conditions in some part of living organisms and testing models by viscosity measurement in HAAKE Rotovisco CV100 which provide extreme sensitivity for differentials between fine particles, as drug carriers

Relationship between degree of dyspnoea and health-related quality of life in patients with chronic obstructive pulmonary disease

Introduction Dyspnoea is a characteristic symptom of chronic obstructive pulmonary disease (COPD), which impairs everyday functioning of patients. Objective The aim of our study was to evaluate the relationship between the degree of dyspnoea of COPD patients and their health-related quality of life. Method We measured the degree of dyspnoea and health-related quality of life in 85 COPD outpatients (46 male; mean age was 58 ± 12 years; mean forced expiratory volume in one second (FEV1) was 47.9±18.6% predicted). The degree of dyspnoea was assessed by Baseline Dyspnoea Index (BDI), List of Daily Activities (DAL), Visual Analogue Scale (VAS), Modified MRC Dyspnoea Scale, and Borg Category Scale (BCS). The patients filled two standardized questionnaires for measuring health-related quality of life: the generic one - 15D, and the respiratory specific one - the St George’s Respiratory Questionnaire (SGRQ). Total 15D and SGRQ scores, as well as the scores for individual domains of SGRQ (symptoms, activity and impact scores) for each patient were calculated. In 40 out of 85 patients, the same procedure was repeated at the follow-up, with a mean 4-week interval between the visits. Results There were statistically highly significant correlations (p<0.01) between values of all dyspnoea scale scores evaluated and all the health-related quality of life scores. The highest degree of correlation of both total SGRQ and 15D scores was found for the values of BCS (r=0.731 and -0.776, respectively). A statistically significant correlation between the changes of all SGRQ (but not 15D) scores and all dyspnoea score changes (except for MRC) were also recorded. Conclusion The degree of dyspnoea of COPD outpatients that could be well-determined by the scales used in our study clearly reflects the impairment of their health-related quality of life as assessed by the instruments used. All of the questionnaires we used in this study have good measurement properties for their purposes

Relationship between respiratory symptoms and satisfaction with inhaled asthma medication

Introduction: Asthma is the chronic inflammatory disease of the airways, and the inhalation treatment is the most convenient way to deliver the medication directly to the airways. Objective: The aim of our study was to evaluate the relationship between respiratory symptom scores in asthmatic outpatients and their satisfaction with inhaled asthma medication. Method: In 124 patients, (39 males; mean age 45±18 years; mean forced expiratory volume in one second (FEV1) 71.8±23.4% predicted), respiratory symptoms were determined by 4-item questionnaire for most frequent asthma symptoms - cough, wheezing, dyspnea and chest tightness (all of them graded from 1 - without symptoms, 2 - mild, 3 - moderate, and 4 - severe symptoms), with overall score (from 4 to 16), as well as by scale for assessment of sinonasal symptoms − the 20-item sinonasal outcome test (SNOT-20) (in 65 out of 124 patients). SNOT-20 scores ranged from 0 to 5, where higher score indicated more manifested symptom. Patients’ satisfaction was measured by standardized "Satisfaction with Inhaled Asthma Treatment Questionnaire" (SATQ), which scores were calculated for the overall satisfaction as well as for individual domains (effectiveness of treatment, easy application, medication burden, and side-effects and related worries). The bigger the score the better the satisfaction, and vice versa. Results: The highest degree of correlation with overall satisfaction scores was found (using the Pearson’s coefficient of linear correlation) for the scores of wheezing (r=-0.271; p=0.002). SNOT-20 scores best correlated with side-effects and worries domain scores. Conclusion: The severity of respiratory symptoms in the asthmatics is strongly correlated with satisfaction with inhaled medication. Improving the asthmatic symptoms Results in enhancement of their satisfaction with inhaled medication and compliance