Predicting Protein Phenotypes Based on Protein-Protein Interaction Network

BACKGROUND: Identifying associated phenotypes of proteins is a challenge of the modern genetics since the multifactorial trait often results from contributions of many proteins. Besides the high-through phenotype assays, the computational methods are alternative ways to identify the phenotypes of proteins. METHODOLOGY/PRINCIPAL FINDINGS: Here, we proposed a new method for predicting protein phenotypes in yeast based on protein-protein interaction network. Instead of only the most likely phenotype, a series of possible phenotypes for the query protein were generated and ranked according to the tethering potential score. As a result, the first order prediction accuracy of our method achieved 65.4% evaluated by Jackknife test of 1,267 proteins in budding yeast, much higher than the success rate (15.4%) of a random guess. And the likelihood of the first 3 predicted phenotypes including all the real phenotypes of the proteins was 70.6%. CONCLUSIONS/SIGNIFICANCE: The candidate phenotypes predicted by our method provided useful clues for the further validation. In addition, the method can be easily applied to the prediction of protein associated phenotypes in other organisms

2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death the Task Force for the Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death of the European Society of Cardiology (ESC) Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC)

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Skin bacterial infections – always a topical problem

Bacterial skin infections are one of the most common reasons for visiting a dermatologist. A huge number of different microor-ganisms live on the human skin, but sometimes due to some external and internal factors the balance is disturbed, which leads to the predominance of one or more colonies and the subsequent development of the infection. Often staphylococci or streptococci are the cause of pyodermias (this is how skin bacterial infections are usually called). In the treatment of pyodermias, local antibacterial drugs are most often used. But given the free access to antibiotics and their thoughtless use, the sensitivity of many strains of microorganisms to the effects of drugs is reduced, which in many cases makes treatment difficult. According to various data, the sensitivity to fusidic acid remains very high, which makes fusidic acid-based drugs an optimal choice for therapy of bacterial infections. It is worth noting that recent studies have also demonstrated the anti-inflammatory activity of fusidic acid, which has a positive effect on the effectiveness of therapy. In today’s realities, the problem of bacterial skin infections remains as urgent as ever. Prolonged use of personal protective equipment and, in particular, medical masks creates ideal conditions for increased growth of opportunistic microorganisms. In this article, we present a case from our own practice. Impetigo developed in a patient after improper use of personal protective equipment. Fusidic acid topical therapy achieved a good clinical result after only 7 days. Thus, given the prevalence of pyodermias, fusidic acid-based drugs may be the optimal solution to the problem

Diffuse hair loss in women: causes and therapeutic approach

Throughout human history, women have paid great attention to the beauty of their hair, and modern women are no exception. About 63% of young American women use different nutritional supplements to prevent hair loss. Diffuse hair loss is quite common in women and can occur against the background of various events: pregnancy, pre- and post-menopause, chronic diseases, etc. The most common is telogen effluvium (TE), which begins 2-3 months after the trigger event. Usually, TE process stops on its own, but can also become chronic. For many women, pregnancy and associated psycho-emotional stress become the triggering event, and in 75% of cases hair loss can become chronic.In fact, TE is a violation of the hair growth cycle. First of all, it is necessary to exclude the trigger factor from the patient's life and only then to start normalizing the hair growth cycle and improve the quality of hair follicle nutrition. The most effective topical remedy for the treatment of diffuse hair loss is minoxidil. The reasons for its clinical effectiveness have not been fully studied, but it is known that it prolongs the hair growth phase. Unfortunately, after cancellation of the drug, hair loss is often renewed. Avoiding these effects is possible with a comprehensive approach to therapy. Inclusion of additional components in the therapy scheme, such as vitamin and mineral complexes, growth stimulants, specialized care products, allows to maintain and improve the results of treatment with minoxidil