Currículos Latino-Americanos – A Educação Secundária em perspectiva comparada

O CONGRESSO DE INTERNACIONALIZAÇÃO DA EDUCAÇÃO SUPERIOR – CIES 2019 é um evento in- ternacional, que reúne professores, pesquisadores e estudantes de graduação e pós-graduação para divulgar a produção científica no campo da Internacionalização do Ensino Superior e fortalecer a cooperação internacional entre diferentes instituições de ensino e grupos de pesquisa no âmbito do MERCOSUL. A iniciativa é fruto de uma parceria entre pesquisadores da Universidade Federal da Integra- ção Latino-Americana (UNILA - Brasil), a Universidad Nacional del Litoral (UNL - Argentina), a Uni- versidad Nacional de Asunción (UNA - Paraguay) e a Universidad de la República (UDeLaR - Uru- guay), que atuam em projetos vinculados ao Setor Educacional do MERCOSUL, no Núcleo de Estudos e Investigações em Educação Superior. O evento será realizado nos dias 4, 5 e 6 de Setembro de 2019 no campus PTI da UNILA, dentro do Parque Tecnológico da Usina Hidrelétrica de Itaipu, na cidade de Foz do Iguaçu, Paraná, Brasil. A UNILA, sede do evento, é uma universidade temática criada em 2010 pelo governo federal do Brasil com a missão institucional de formar recursos humanos aptos a contribuir com a integra- ção latino-americana, com o desenvolvimento regional e com o intercâmbio cultural, científico e educacional da América Latina, especialmente no MERCOSUL. Sua finalidade, portanto, é conver- ter-se em um espaço de encontros, de trocas e de aprendizagem mútua, que reforçam o compro- misso em prol da pertinência, da excelência e da construção sustentável de um mundo melhor.O trabalho apresenta os resultados de uma extensa pesquisa documental, realizada a partir de históricos escolares relativos à educação secundária de vinte e um países da América Latina e Caribe – Argentina, Belize, Brasil, Bolívia, Chile, Colômbia, Costa Rica, Cuba, El Salvador, Equador, Guatemala, Honduras, Jamaica, México, Nicarágua, Paraguai, Peru, República Dominicana, Trinidad e Tobago, Uruguai e Venezuela. A pesquisa teve como objetivo relacionar os principais componentes curriculares e áreas de conhecimento contemplados na educação secundária dos diferentes países analisados e refletir sobre os processos formativos a que jovens latino-americanas/os e caribenhas/os estão submetidos na atualidade.Núcleo de Estudios e Investigaciones en Educación Superior del Mercosur - NUCLEO Grupo Interdisciplinar de Pesquisa em Educação na América Latina – EducAL/UNILA Instituto Mercosul de Estudos Avançados – IMEA/UNILA Pró-Reitoria de Relações Institucionais e Internacionais – PROINT/UNIL

Totally geodesic subvarieties in the moduli space of curves

In this paper we study totally geodesic subvarieties $Y \subset \mathsf{A}_g$ of the moduli space of principally polarized abelian varieties with respect to the Siegel metric, for $g\geq 4$. We prove that if $Y$ is generically contained in the Torelli locus, then $\dim Y \leq (7g -2)/3$

Holomorphic 1-forms on the moduli space of curves

Since the sixties it is well known that there are no non-trivial closed holomorphic $1$-forms on the moduli space $\mathcal{M}_g$ of smooth projective curves of genus $g>2$. In this paper, we strengthen such result proving that for $g\geq 5$ there are no non-trivial holomorphic $1$-forms. With this aim, we prove an extension result for sections of locally free sheaves $\mathcal{F}$ on a projective variety $X$. More precisely, we give a characterization for the surjectivity of the restriction map $\rho_D:H^0(\mathcal{F})\to H^0(\mathcal{F}|_{D})$ for divisors $D$ in the linear system of a sufficiently large multiple of a big and semiample line bundle $\mathcal{L}$. Then, we apply this to the line bundle $\mathcal{L}$ given by the Hodge class on the Deligne Mumford compactification of $\mathcal{M}_g$.Comment: New version with several improvement

Quillen connection and the uniformization of Riemann surfaces

The Quillen connection on ${\mathcal L} \rightarrow {\mathcal M}_g$, where ${\mathcal L}^*$ is the Hodge line bundle over the moduli stack of smooth complex projective curves curves ${\mathcal M}_g$, $g \geq 5$, is uniquely determined by the condition that its curvature is the Weil--Petersson form on ${\mathcal M}_g$. The bundle of holomorphic connections on ${\mathcal L}$ has a unique holomorphic isomorphism with the bundle on ${\mathcal M}_g$ given by the moduli stack of projective structures. This isomorphism takes the $C^\infty$ section of the first bundle given by the Quillen connection on ${\mathcal L}$ to the $C^\infty$ section of the second bundle given by the uniformization theorem. Therefore, any one of these two sections determines the other uniquely

A New Frontier of Photocatalysis Employing Micro-Sized TiO2: Air/Water Pollution Abatement and Self-Cleaning/ Antibacterial Applications

This chapter presents the use of a commercial micro-sized TiO2 powder as an alternative to the traditional nano-powders as semiconductors in photocatalytic processes. Results of the photocatalytic efficiency towards the photodegradation of the traditional pollutant molecules both in gas phase (nitrogen oxides (NOx) and volatile organic compounds (VOCs)) and in water phase (phenol) are presented and compared to the results obtained with two nano-sized reference powders. Micro-sized TiO2 is also industrially coated at the surfaces of porcelain grés tiles (Active Clean Air and Antibacterial Ceramic™). The possibility to have a photocatalytic material, strongly stuck at the surface of a vitrified tile, increases the use of photocatalysis in real conditions: no problem of filtration of the semiconductor from the liquid medium after use and no risks of leakage of nanoparticles in the atmosphere. Tests were performed using reactors equipped with UV-A lamps and with suitable analytical systems, depending on the final purpose. Characterization data from both powders and coated tiles are put in correlation with the photocatalytic results to understand the semiconductor action during the photocatalytic process. Polluting molecules were chosen in order to cover all the common aspects of environmental pollution: NOx and some VOCs represent the model molecules to test the efficiency of the micro-sized TiO2 (degradation from the pristine molecule to CO2 or inorganic salts) in gas phase. As for the water pollution, phenol was chosen as common pollutant in worldwide rivers. Moreover, tests on self-cleaning and antibacterial properties are also reported. The positive results of micro-sized TiO2 both in powder and coated onto the surface of porcelain grés tiles open the way to new photocatalytic products that do not make use of nanoscale powders avoiding problems to human safety caused by the inherent toxicity of the nanoparticles

SETBP1 induces transcription of a network of development genes by acting as an epigenetic hub

SETBP1 variants occur as somatic mutations in several hematological malignancies such as atypical chronic myeloid leukemia and as de novo germline mutations in the Schinzel-Giedion syndrome. Here we show that SETBP1 binds to gDNA in AT-rich promoter regions, causing activation of gene expression through recruitment of a HCF1/KMT2A/PHF8 epigenetic complex. Deletion of two AT-hooks abrogates the binding of SETBP1 to gDNA and impairs target gene upregulation. Genes controlled by SETBP1 such as MECOM are significantly upregulated in leukemias containing SETBP1 mutations. Gene ontology analysis of deregulated SETBP1 target genes indicates that they are also key controllers of visceral organ development and brain morphogenesis. In line with these findings, in utero brain electroporation of mutated SETBP1 causes impairment of mouse neurogenesis with a profound delay in neuronal migration. In summary, this work unveils a SETBP1 function that directly affects gene transcription and clarifies the mechanism operating in myeloid malignancies and in the Schinzel- Giedion syndrome caused by SETBP1 mutations.Peer reviewe

De novo UBE2A mutations are recurrently acquired during chronic myeloid leukemia progression and interfere with myeloid differentiation pathways

Despite the advent of tyrosine kinase inhibitors, a proportion of chronic myeloid leukemia patients in chronic phase fails to respond to Imatinib or to second generation inhibitors and progress to blast crisis. Limited improvements in the understanding of the molecular mechanisms responsible for chronic myeloid leukemia transformation from chronic phase to the aggressive blast crisis were achieved until now. We present here a massive parallel sequencing analysis of 10 blast crisis samples and of the corresponding autologous chronic phase controls which reveals, for the first time, recurrent mutations affecting the ubiquitin-conjugating enzyme E2A gene (UBE2A, formerly RAD6A). Additional analyses on a cohort of 24 blast crisis, 41 chronic phase as well as 40 acute myeloid leukemia and 38 atypical chronic myeloid leukemia patients at onset confirmed that UBE2A mutations are specifically acquired during chronic myeloid leukemia progression with a frequency of 16.7% in advanced phases. In vitro studies show that the mutations here described cause a decrease in UBE2A activity, leading to an impairment of myeloid differentiation in chronic myeloid leukemia cells

Integrated Genomic, Functional, and Prognostic Characterization of Atypical Chronic Myeloid Leukemia

Atypical chronic myeloid leukemia (aCML) is a BCR-ABL1-negative clonal disorder, which belongs to the myelodysplastic/myeloproliferative group. This disease is characterized by recurrent somatic mutations in SETBP1, ASXL1 and ETNK1 genes, as well as high genetic heterogeneity, thus posing a great therapeutic challenge. To provide a comprehensive genomic characterization of aCML we applied a high-throughput sequencing strategy to 43 aCML samples, including both whole-exome and RNA-sequencing data. Our dataset identifies ASXL1, SETBP1, and ETNK1 as the most frequently mutated genes with a total of 43.2%, 29.7 and 16.2%, respectively. We characterized the clonal architecture of 7 aCML patients by means of colony assays and targeted resequencing. The results indicate that ETNK1 variants occur early in the clonal evolution history of aCML, while SETBP1 mutations often represent a late event. The presence of actionable mutations conferred both ex vivo and in vivo sensitivity to specific inhibitors with evidence of strong in vitro synergism in case of multiple targeting. In one patient, a clinical response was obtained. Stratification based on RNA-sequencing identified two different populations in terms of overall survival, and differential gene expression analysis identified 38 significantly overexpressed genes in the worse outcome group. Three genes correctly classified patients for overall survival