54 research outputs found
Comparison between endoscopic and surgical treatment of screen-detected versus non-screen-detected colorectal cancers
Resveratrol Inhibits Protein Translation in Hepatic Cells
Resveratrol is a plant-derived polyphenol that extends lifespan and healthspan in model organism. Despite extensive investigation, the biological processes mediating resveratrol's effects have yet to be elucidated. Because repression of translation shares many of resveratrol's beneficial effects, we hypothesized that resveratrol was a modulator of protein synthesis. We studied the effect of the drug on the H4-II-E rat hepatoma cell line. Initial studies showed that resveratrol inhibited global protein synthesis. Given the role of the mammalian Target of Rapamycin (mTOR) in regulating protein synthesis, we examined the effect of resveratrol on mTOR signaling. Resveratrol inhibited mTOR self-phosphorylation and the phosphorylation of mTOR targets S6K1 and eIF4E-BP1. It attenuated the formation of the translation initiation complex eIF4F and increased the phosphorylation of eIF2α. The latter event, also a mechanism for translation inhibition, was not recapitulated by mTOR inhibitors. The effects on mTOR signaling were independent of effects on AMP-activated kinase or AKT. We conclude that resveratrol is an inhibitor of global protein synthesis, and that this effect is mediated through modulation of mTOR-dependent and independent signaling
Status of hepatic DNA methylome predetermines and modulates the severity of non-alcoholic fatty liver injury in mice
Insulin resistance is associated with epigenetic and genetic regulation of mitochondrial DNA in obese humans
THE PHYSIOLOGY OF PARATHYROID HORMONE-RELATED PROTEIN: An Emerging Role as a Developmental Factor
Epigenetic and Metabolism: Glucose and Homeotic Transcription Factor PREP1 VRP Suggested Epigenetics and Metabolism
Prevalence of hypertension and diabetes after exposure to extracorporeal shock-wave lithotripsy in patients with renal calculi: a retrospective non-randomized data analysis
Transitional cell carcinoma with extension of the renal vein and IVC tumor thrombus: report of three cases and literature review
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