Feasibility and Preliminary Effectiveness of a Tele-Prehabilitation Program in Esophagogastric Cancer Patients

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited https://creativecommons.org/licenses/by/4.0/Peer reviewedPublisher PD

What are the impact and the optimal design of a physical prehabilitation program in patients with esophagogastric cancer awaiting surgery? : A systematic review

EP was supported by a grant from the Fonds National de la Recherche Scientifique (FRIA - FNRS). GR was supported by a grant from the Institut de Recherche Expérimentale et Clinique (Université catholique de Louvain, Brussels, Belgium). The funders had no role in the study design, collection, analysis and interpretation of data and in writing the manuscript.Peer reviewedPublisher PD

High-intensity aerobic interval training and resistance training are feasible in rectal cancer patients undergoing chemoradiotherapy: a feasibility randomized controlled study

Background: There has been growing evidence of the benefits of high-intensity aerobic interval training (HIIT) and resistance training (RES) for populations with cancer. However, these two modalities have not yet been performed alone in rectal cancer patients undergoing neoadjuvant chemoradiotherapy (NACRT). Therefore, this study aimed to determine the feasibility of HIIT and RES in rectal cancer patients undergoing NACRT. Materials and methods: Rectal cancer patients set to undergo NACRT were randomly assigned to HIIT intervention, RES intervention, or the usual care. Feasibility of HIIT and RES was assessed by measuring recruitment rate, adherence (retention rate, attendance rate, and exercise sessions duration and intensity), and adverse events. Endpoints (changes in fatigue, health-related quality of life, depression, daytime sleepiness, insomnia, sleep quality, functional exercise capacity, and executive function) were assessed at baseline and at week 5. Results: Among the 20 eligible patients, 18 subjects were enrolled and completed the study, yielding a 90% recruitment rate and 100% retention rate. Attendance at exercise sessions was excellent, with 92% in HIIT and 88% in RES. No exercise-related adverse events occurred. Conclusion: This study demonstrated that HIIT and RES are feasible in rectal cancer patients undergoing NACRT. Trial registration: www.clinicaltrials.gov, NCT03252821 (date of registration: March 30, 2017)

Exercise as a part of treatment in cancer : specific focus on the pretreatment and treatment phases

Strong evidence indicates that physical activity and exercise are key interventions for use in the management of patients with cancer. Despite the known benefits of exercise across the entire cancer care continuum, research remains necessary to identify specific exercise prescriptions for the pretreatment and the treatment phases. In the present thesis, we investigated for the pretreatment phase, in two systematic reviews, the current evidence for prehabilitation in patients with cancer. The first demonstrated that a combined aerobic and resistance prehabilitation may benefit patients with various cancer types. The second reported the feasibility, safety and some benefits of prehabilitation in patients with esophagogastric cancer. Then, we reported, in two pilot studies, the feasibility, safety and preliminary effectiveness of prehabilitation with a telerehabilitation system in patients with esophagogastric and colon cancer. For the treatment phase, we emphasized, in a narrative review, that exercise performed by cancer patients during radiotherapy may manage some treatment-related adverse effects. Then, we founded in a randomized controlled trial, that high-intensity interval training (HIIT) and resistance training displayed beneficial effects on cancer-related fatigue and functional exercise capacity in prostate cancer patients undergoing radiotherapy as compared to usual care. Finally, the feasibility and safety of HIIT and resistance training were demonstrated in rectal cancer patients undergoing neoadjuvant chemoradiotherapy.(BIFA - Sciences biomédicales et pharmaceutiques) -- UCL, 202

Effects of preoperative combined aerobic and resistance exercise training in cancer patients undergoing tumour resection surgery: A systematic review of randomised trials

BACKGROUNG : Surgical management remains the cornerstone of treatment for many cancers, but is associated with a high rate of postoperative complications, which are linked to poor preoperative functional capacity. Prehabilitation may have beneficial effects on functional capacity and postoperative outcomes. We evaluated the effects of prehabilitation combining endurance and resistance training (CT) on physical fitness, quality of life (QoL) and postoperative outcomes in cancer patients undergoing tumour resection surgery. METHODS : We performed a literature search in PubMed, PEDro, EMBASE (via Scopus) and the Cochrane library for clinical trials until September 2017. Randomised controlled trials investigating the effects of CT in adult cancer patients undergoing surgery were included when at least one of the following outcomes was reported: physical capacity, muscle strength, QoL, length of stay (LOS), postoperative complications and mortality. RESULTS : Ten studies (360 patients) were retrieved and included patients with lung, colorectal, bladder and oesophageal cancer. No adverse effects of CT were reported. Compared with the control group, CT improved physical capacity (3 of 5 studies), muscle strength (2 of 3 studies) and some domains of QoL (2 of 4 studies), shortened LOS (1 of 6 studies) and reduced postoperative pulmonary complications (2 of 6 studies). CONCLUSIONS : The benefits of CT in cancer population are demonstrated. CT may improve physical fitness and QoL and decrease LOS and postoperative pulmonary complications. However, our conclusions are limited by the heterogeneity of the preoperative CT programs, patient characteristics and measurement tools. Future research is required to determine the optimal composition of CT

Effects of preoperative combined aerobic and resistance exercise training in cancer patients undergoing resection surgery: A systematic review of randomised trials

Background: Surgical management remains the cornerstone of treatment for many cancers, but is associated with a high rate of postoperative complications, which are linked to poor preoperative functional capacity. Prehabilitation may have beneficial effects on functional capacity and postoperative outcomes. Purpose: T he purpose of this study is to evaluate the effects of prehabilitation combining endurance and resistance training (CT) on physical fitness, quality of life (QoL) and postoperative outcomes in cancer patients undergoing tumour resection surgery. Methods: We performed a literature search in PubMe d, PEDro, EMBASE (via Scopus) and the Cochrane library for clinical trials until September 2017. Randomised controlled trials investigating the effects of CT in adult cancer patients undergoing surgery were included when at least one of the following outcomes was reported: physical capacity, muscle strength, QoL, length of stay (LOS), postoperative complications and mortality. Results: Ten studies (360 patients) were r etrieved and included patients with lung, colorectal, bladder and oesophageal cancer. No adverse effects of CT were reported. Compared with the control group, CT improved physical capacity (3 of 5 studies), muscle strength (2 of 3 studies) and some domains of QoL (2 of 4 studies), shortened LOS (1 of 6 studies) and reduced postoperative pulmonary complications (2 of 6 studies). Conclusion(s): The benefits o f CT in cancer population are demonstrated. CT may improve physical fitness and QoL and decrease LOS and postoperative pulmonary complications. However, our conclusions are limited by the heterogeneity of the preoperative CT programs, patient characteristics and measurement tools. Future research is required to determine the optimal composition of CT. Implications: Prehabilitation in cancer patients undergoing tumour resection surgery may be an opportunity to optimize functional capacity before surgery and to improve postoperative recovery and quality of life. This preoperative process makes patients with cancer involved in their treatment and should be encourage by health care providers