Syn-kinematic sedimentary systems as constraints on the structural response of thrust belts : re-examining the structural style of the Maghrebian thrust belt of Eastern Sicily

We are indebted to the generosity of the late Fabio Lentini. While he may not have agreed with our findings, he nevertheless openly and cheerfully shared his mapping and insight of Sicilian geology. This work also builds upon many years’ collaboration between us, initiated by the late Mario Grasso (the Pantagruelian Master of Speranza et alii, 2018). The mapping of Lentini, Grasso and colleagues represents a remarkable resource for future geologists. We dedicate this contribution to their memory. We thank Sveva Corrado and an anonymous referee for constructive comments on an earlier draft of this paper. Butler’s Sicilian field research has been variously funded by the UK’s Natural Environment Research Council and the Royal Society. Maniscalco acknowledges “Fondi per la Ricerca di AteneoPiano per la Ricerca 2016/2018”. Pinter was supported through a PhD grant funded by the BG Group (now Shell) and Brazil’s National Council for Scientific and Technological Development (CNPq).Peer reviewedPublisher PD

Tracking sand-fairways through a deformed turbidite system : the Numidian (Miocene) of Central Sicily, Italy

The research presented here is funded by BG Group in partnership with CNPq-Brazil (National Council for Scientific and Technological Development). Rosanna Maniscalco acknowledges a FIR 2014 grant awarded from the University of Catania. We thank Christian Haug Eide, David Hodgson and Enrico Tavarnelli for constructive and thorough reviews on an earlier draft that have greatly improved this contribution.Peer reviewedPublisher PD

Deep-water sand-fairway mapping as a tool for tectonic restoration : decoding Miocene central Mediterranean palaeogeography using the Numidian turbidites of southern Italy

The research presented here was funded by BG-Shell in partnership with CNPq-Brazil (National Council for Scientific and Technological Development). Rosanna Maniscalco acknowledges a Piano Triennale della Ricerca 2016-2018 grant awarded from the University of Catania.Peer reviewedPublisher PD

The Numidian of Sicily revisited : a thrust-influenced confined turbidite system

The research presented here is funded by BG Group in partnership with CNPq-Brazil (National Council for Scientific and Technological Development). Rosanna Maniscalco acknowledges a FIR 2014 grant awarded by the University of Catania, Sicily. Patricia Pinter thanks Prof. Karin Goldberg for helpful discussions in the field and Thisiane dos Santos, Francesca Porro and Dario La Camiola for extensive field assistance. Finally we thank Simon Lomas and the anonymous reviewers for their constructive comments that helped us to improve this paper.Peer reviewedPublisher PD

Automatically Harnessing Sparse Acceleration

Sparse linear algebra is central to many scientific programs, yet compilers fail to optimize it well. High-performance libraries are available, but adoption costs are significant. Moreover, libraries tie programs into vendor-specific software and hardware ecosystems, creating non-portable code. In this paper, we develop a new approach based on our specification Language for implementers of Linear Algebra Computations (LiLAC). Rather than requiring the application developer to (re)write every program for a given library, the burden is shifted to a one-off description by the library implementer. The LiLAC-enabled compiler uses this to insert appropriate library routines without source code changes. LiLAC provides automatic data marshaling, maintaining state between calls and minimizing data transfers. Appropriate places for library insertion are detected in compiler intermediate representation, independent of source languages. We evaluated on large-scale scientific applications written in FORTRAN; standard C/C++ and FORTRAN benchmarks; and C++ graph analytics kernels. Across heterogeneous platforms, applications and data sets we show speedups of 1.1$\times$ to over 10$\times$ without user intervention.Comment: Accepted to CC 202

PAREJA [Material gráfico]

ADQUIRIDA POR EL COLECCIONISTA EN LAS PALMAS G.C.FOTO DE SEÑORA SENTDA EN SILLA CON CABALLERO DE PIE A SU LADOCopia digital. Madrid : Ministerio de Educación, Cultura y Deporte. Subdirección General de Coordinación Bibliotecaria, 201

Functional analysis of non-genetic resistance to platinum in epithelial ovarian cancer reveals a role for the MBD3-NuRD complex in resistance development

SIMPLE SUMMARY: Most epithelial ovarian cancer (EOC) patients, although initially responsive to standard treatment with platinum-based chemotherapy, develop platinum resistance over the clinical course and succumb due to drug-resistant metastases. It has long been hypothesized that resistance to platinum develops as a result of epigenetic changes within tumor cells evolving over time. In this study, we investigated epigenomic changes in EOC patient samples, as well as in cell lines, and showed that profound changes at enhancers result in a platinum-resistant phenotype. Through correlation of the epigenomic alterations with changes in the transcriptome, we could identify potential novel prognostic biomarkers for early patient stratification. Furthermore, we applied a combinatorial RNAi screening approach to identify suitable targets that prevent the enhancer remodeling process. Our results advance the molecular understanding of epigenetic mechanisms in EOC and therapy resistance, which will be essential for the further exploration of epigenetic drug targets and combinatorial treatment regimes. ABSTRACT: Epithelial ovarian cancer (EOC) is the most lethal disease of the female reproductive tract, and although most patients respond to the initial treatment with platinum (cPt)-based compounds, relapse is very common. We investigated the role of epigenetic changes in cPt-sensitive and -resistant EOC cell lines and found distinct differences in their enhancer landscape. Clinical data revealed that two genes (JAK1 and FGF10), which gained large enhancer clusters in resistant EOC cell lines, could provide novel biomarkers for early patient stratification with statistical independence for JAK1. To modulate the enhancer remodeling process and prevent the acquisition of cPt resistance in EOC cells, we performed a chromatin-focused RNAi screen in the presence of cPt. We identified subunits of the Nucleosome Remodeling and Deacetylase (NuRD) complex as critical factors sensitizing the EOC cell line A2780 to platinum treatment. Suppression of the Methyl-CpG Binding Domain Protein 3 (MBD3) sensitized cells and prevented the establishment of resistance under prolonged cPt exposure through alterations of H3K27ac at enhancer regions, which are differentially regulated in cPt-resistant cells, leading to a less aggressive phenotype. Our work establishes JAK1 as an independent prognostic marker and the NuRD complex as a potential target for combinational therapy

The report of the Round Robin Test by SIMS: Interlaminar fracture behaviour on glass woven fabric reinforced vinylester composites

International audienc

The report of the Round Robin Test by SIMS: Interlaminar fracture behaviour on glass woven fabric reinforced vinylester composites

International audienc