Lymphocyte Subpopulation Number and Function in Infancy

Normal values for percentages of lymphocyte subpopulations and functional responses to mitogen stimulation in infancy are not well established. In the present study, lymphocyte subpopulations were examined in umbilical cord blood samples and in peripheral blood samples drawn before 7 and 24 months of age (mean age 10.4 months) from a healthy population of infants born in Tucson, Arizona. Results indicate significant increases occurred from birth to later infancy in the percentages of total T cells (CD3), T-cell subsets (CD4, CD8) and B cells (CD20). The CD4/CD8 ratio and the functional responses to ConA and PWM mitogens significantly decreased from birth to later infancy. PHA responsiveness did not show a significant change. Results from cross-sectional analyses (n=271) were supported in a smaller longitudinal subset (n=37). There were no detectable ethnic- or gender-related differences in cord blood or samples obtained in later infancy. The normal values established in this study will be useful in studies of immune-system maturation and in the clinical evaluation of newborns, infants, and toddlers suspected of either acquired or congenital immune-deficiency states

The Effect Of Microcounseling On Attentiveness And Sensitivity To Nonverbal Cues

Basale Soziologie. - Opladen : Westdt. Verl. - (Studienreihe Gesellschaft) Hauptprobleme / Michael Schmid ... - 4., neubearb. u. erw. Aufl. - 1991. - XI, 269 S. [1. Aufl. 1975] Theoretische Modelle / M. Schmid ... - 4., neubearb. u. erw. Aufl. - 1991. - XIII, 310 S. [1. Aufl. 1975] Wissenschaftstheorie / Bernhard Giesen ; Michael Schmid. - 1977. - 272 S

Levels of malondialdehyde-related immune reactants in a lupus prone mouse strain

The levels of malondialdehyde (MDA)-specific antibodies in lupus-prone MRL/ lpr mice of different ages were compared to those against DNA. These mice elicited anti-MDA antibodies earlier and in higher levels that anti-DNA antibodies. The levels of immune complexes containing MDA adducts were also higher in these mice when compared to 3 other non-lupus strains. MDA binding to a 100 kDa serum protein was observed in 3 and 5 month old mice. Immune complexes involving anti-MDA antibodies and MDA adducts may represent an additional mechanism that contributes to disease pathogenesis in these mice