Changes in storm tracks and energy transports in a warmer climate simulated by the GFDL CM2.1 model

Storm tracks play a major role in regulating the precipitation and hydrological cycle in midlatitudes. The changes in the location and amplitude of the storm tracks in response to global warming will have significant impacts on the poleward transport of heat, momentum and moisture and on the hydrological cycle. Recent studies have indicated a poleward shift of the storm tracks and the midlatitude precipitation zone in the warming world that will lead to subtropical drying and higher latitude moistening. This study agrees with this key feature for not only the annual mean but also different seasons and for the zonal mean as well as horizontal structures based on the analysis of Geophysical Fluid Dynamics Laboratory (GFDL) CM2.1 model simulations. Further analyses show that the meridional sensible and latent heat fluxes associated with the storm tracks shift poleward and intensify in both boreal summer and winter in the late twenty-first century (years 2081-2100) relative to the latter half of the twentieth century (years 1961-2000). The maximum dry Eady growth rate is examined to determine the effect of global warming on the time mean state and associated available potential energy for transient growth. The trend in maximum Eady growth rate is generally consistent with the poleward shift and intensification of the storm tracks in the middle latitudes of both hemispheres in both seasons. However, in the lower troposphere in northern winter, increased meridional eddy transfer within the storm tracks is more associated with increased eddy velocity, stronger correlation between eddy velocity and eddy moist static energy, and longer eddy length scale. The changing characteristics of baroclinic instability are, therefore, needed to explain the storm track response as climate warms. Diagnosis of the latitude-by-latitude energy budget for the current and future climate demonstrates how the coupling between radiative and surface heat fluxes and eddy heat and moisture transport influences the midlatitude storm track response to global warming. Through radiative forcing by increased atmospheric carbon dioxide and water vapor, more energy is gained within the tropics and subtropics, while in the middle and high latitudes energy is reduced through increased outgoing terrestrial radiation in the Northern Hemisphere and increased ocean heat uptake in the Southern Hemisphere. This enhanced energy imbalance in the future climate requires larger atmospheric energy transports in the midlatitudes which are partially accomplished by intensified storm tracks. Finally a sequence of cause and effect for the storm track response in the warming world is proposed that combines energy budget constraints with baroclinic instability theory

DeSTSeg: Segmentation Guided Denoising Student-Teacher for Anomaly Detection

Visual anomaly detection, an important problem in computer vision, is usually formulated as a one-class classification and segmentation task. The student-teacher (S-T) framework has proved to be effective in solving this challenge. However, previous works based on S-T only empirically applied constraints on normal data and fused multi-level information. In this study, we propose an improved model called DeSTSeg, which integrates a pre-trained teacher network, a denoising student encoder-decoder, and a segmentation network into one framework. First, to strengthen the constraints on anomalous data, we introduce a denoising procedure that allows the student network to learn more robust representations. From synthetically corrupted normal images, we train the student network to match the teacher network feature of the same images without corruption. Second, to fuse the multi-level S-T features adaptively, we train a segmentation network with rich supervision from synthetic anomaly masks, achieving a substantial performance improvement. Experiments on the industrial inspection benchmark dataset demonstrate that our method achieves state-of-the-art performance, 98.6% on image-level ROC, 75.8% on pixel-level average precision, and 76.4% on instance-level average precision

Changes in storm tracks and energy transports in a warmer climate simulated by the GFDL CM2.1 model

Storm tracks play a major role in regulating the precipitation and hydrological cycle in midlatitudes. The changes in the location and amplitude of the storm tracks in response to global warming will have significant impacts on the poleward transport of heat, momentum and moisture and on the hydrological cycle. Recent studies have indicated a poleward shift of the storm tracks and the midlatitude precipitation zone in the warming world that will lead to subtropical drying and higher latitude moistening. This study agrees with this key feature for not only the annual mean but also different seasons and for the zonal mean as well as horizontal structures based on the analysis of Geophysical Fluid Dynamics Laboratory (GFDL) CM2.1 model simulations. Further analyses show that the meridional sensible and latent heat fluxes associated with the storm tracks shift poleward and intensify in both boreal summer and winter in the late twenty-first century (years 2081-2100) relative to the latter half of the twentieth century (years 1961-2000). The maximum dry Eady growth rate is examined to determine the effect of global warming on the time mean state and associated available potential energy for transient growth. The trend in maximum Eady growth rate is generally consistent with the poleward shift and intensification of the storm tracks in the middle latitudes of both hemispheres in both seasons. However, in the lower troposphere in northern winter, increased meridional eddy transfer within the storm tracks is more associated with increased eddy velocity, stronger correlation between eddy velocity and eddy moist static energy, and longer eddy length scale. The changing characteristics of baroclinic instability are, therefore, needed to explain the storm track response as climate warms. Diagnosis of the latitude-by-latitude energy budget for the current and future climate demonstrates how the coupling between radiative and surface heat fluxes and eddy heat and moisture transport influences the midlatitude storm track response to global warming. Through radiative forcing by increased atmospheric carbon dioxide and water vapor, more energy is gained within the tropics and subtropics, while in the middle and high latitudes energy is reduced through increased outgoing terrestrial radiation in the Northern Hemisphere and increased ocean heat uptake in the Southern Hemisphere. This enhanced energy imbalance in the future climate requires larger atmospheric energy transports in the midlatitudes which are partially accomplished by intensified storm tracks. Finally a sequence of cause and effect for the storm track response in the warming world is proposed that combines energy budget constraints with baroclinic instability theory

Studying antibiotic–membrane interactions via X-ray diffraction and fluorescence microscopy

AbstractAntibiotic drug resistance is a serious issue for the treatment of bacterial infection. Understanding the resistance to antibiotics is a key issue for developing new drugs. We used penicillin and sulbactam as model antibiotics to study their interaction with model membranes. Cholesterol was used to target the membrane for comparison with the well-known insertion model. Lamellar X-ray diffraction (LXD) was used to determine membrane thickness using successive drug-to-lipid molar ratios. The aspiration method for a single giant unilamellar vesicle (GUV) was used to monitor the kinetic binding process of antibiotic–membrane interactions in an aqueous solution. Both penicillin and sulbactam are found positioned outside the model membrane, while cholesterol inserts perpendicularly into the hydrophobic region of the membrane in aqueous solution. This result provides structural insights for understanding the antibiotic–membrane interaction and the mechanism of antibiotics