7 research outputs found
Two XMAP215/TOG Microtubule Polymerases, Alp14 and Dis1, Play Non-Exchangeable, Distinct Roles in Microtubule Organisation in Fission Yeast
- Publication venue
- 'MDPI AG'
- Publication date
- 15/10/2019
- Field of study
Proper bipolar spindle assembly underlies accurate chromosome segregation. A cohort of microtubule-associated proteins orchestrates spindle microtubule formation in a spatiotemporally coordinated manner. Among them, the conserved XMAP215/TOG family of microtubule polymerase plays a central role in spindle assembly. In fission yeast, two XMAP215/TOGmembers, Alp14 and Dis1, share essential roles in cell viability; however how these two proteins functionally collaborate remains undetermined. Here we show the functional interplay and specification of Alp14 and Dis1. Creation of new mutant alleles of alp14, which display temperature sensitivity in the absence of Dis1, enabled us to conduct detailed analyses of a double mutant. We have found that simultaneous inactivation of Alp14 and Dis1 results in early mitotic arrest with very short, fragile spindles. Intriguingly, these cells often undergo spindle collapse, leading to a lethal “cut” phenotype. By implementing an artificial targeting system, we have shown that Alp14 and Dis1 are not functionally exchangeable and as such are not merely redundant paralogues. Interestingly, while Alp14 promotes microtubule nucleation, Dis1 does not. Our results uncover that the intrinsic specification, not the spatial regulation, between Alp14 and Dis1 underlies the collaborative actions of these two XMAP215/TOG members in mitotic progression, spindle integrity and genome stability.This work was supported by the Japan Society for the Promotion of Science (JSPS) (KAKENHI Scientific Research (A) 16H02503 and the Program for Advancing Strategic International Networks to Accelerate the Circulation of Talented Researchers (S2902) to T.T. and Scientific Research (C) 19K05813 to M.Y.)
Characterisation of putative class 1A DHODH-like proteins from Mucorales and dematiaceous mould species
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 02/08/2023
- Field of study
Olorofim is a new antifungal in clinical development which has a novel mechanism of action against dihydroorotate dehydrogenase (DHODH). DHODH form a ubiquitous family of enzymes in the de novo pyrimidine biosynthetic pathway and are split into class 1A, class 1B and class 2. Olorofim specifically targets the fungal class 2 DHODH present in a range of pathogenic moulds. The nature and number of DHODH present in many fungal species have not been addressed for large clades of this kingdom. Mucorales species do not respond to olorofim; previous work suggests they have only class 1A DHODH and so lack the class 2 target that olorofim inhibits. The dematiaceous moulds have mixed susceptibility to olorofim, yet previous analyses imply that they have class 2 DHODH. As this is at odds with their intermediate susceptibility to olorofim, we hypothesised that these pathogens may maintain a second class of DHODH, facilitating pyrimidine biosynthesis in the presence of olorofim. The aim of this study was to investigate the DHODH repertoire of clinically relevant species of Mucorales and dematiaceous moulds to further characterise these pathogens and understand variations in olorofim susceptibility. Using bioinformatic analysis, S. cerevisiae complementation and biochemical assays of recombinant protein, we provide the first evidence that two representative members of the Mucorales have only class 1A DHODH, substantiating a lack of olorofim susceptibility. In contrast, bioinformatic analyses initially suggested that seven dematiaceous species appeared to harbour both class 1A-like and class 2-like DHODH genes. However, further experimental investigation of the putative class 1A-like genes through yeast complementation and biochemical assays characterised them as dihydrouracil oxidases rather than DHODHs. These data demonstrate variation in dematiaceous mould olorofim susceptibility is not due to a secondary DHODH and builds on the growing picture of fungal dihydrouracil oxidases as an example of horizontal gene transfer
Individual differences in highly skilled visual perceptual-motor striking skill
- Author
- A Field
- Alasdair R. Dempsey
- Allen G. Harbaugh
- AW Hubbard
- B Abernethy
- B Abernethy
- B Elliott
- Corinne Reid
- D Fortenbaugh
- D Mattos
- DJS Mattos
- H Katsumata
- J Shim
- JL Taylor
- JM Wood
- JN Vickers
- John Brenton
- JR Weissensteiner
- K Davids
- K Yarrow
- KM Newell
- L Uehara
- LG Portney
- M Dicks
- M Wilson
- MC Stuelcken
- MF Land
- RA Pinder
- RA Pinder
- RJ Bootsma
- S Albrecht
- S Müller
- S Müller
- S Müller
- S Müller
- S Müller
- Sean Müller
- SM Rosalie
- WI Schöllhorn
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Exploring the roles of kinesin-8 in mitotic progression
- Author
- Publication venue
- UCL (University College London)
- Publication date
- Field of study
The mitotic spindle employs myriad proteins for chromosome segregation, in addition to monitoring the fidelity of this process and correcting mistakes before they become problematic for daughter cells. Key players in mitosis include the superfamily of kinesin motors, a variety of microtubule-associated proteins (MAPs) and members of the spindle assembly checkpoint; deregulation of these factors has been observed in multiple tumour types. Our interest lies in the conserved family of microtubule plus-end directed kinesin-8 motors, which have been implicated in some breast and colorectal cancers. Klp5/Klp6 constitute the S. pombe kinesin-8 complex, and like the human counterpart, Kif18A, localise dynamically on the spindle, interact with kinetochores and regulate microtubule dynamics to allow a timely and coordinated metaphaseanaphase transition. Although these functions have been assigned in multiple species, exact mechanisms of the diverse kinesin-8 functions have not been elucidated, particularly in fission yeast. In contrast to prior studies of Klp5/6, where mainly deletion or truncation mutants were used, we employ a targeted mutagenesis approach to look directly at kinesin-8 function and regulation. Though Klp5/6 are non-essential, we exploit their synthetic lethality with various MAPs to isolate temperature-sensitive alleles of klp5. We find that a specific mutation in the non-motor kinesin tail has a deletion-like phenotype, disrupting chromosome congression, bipolar kinetochore attachment, negative regulation of spindle length and overall control of microtubule dynamics. Additionally, the processivity of the mutant is greatly impaired in vitro. Using this loss-of-function mutant with the deletion of XMAP215/TOG family microtubule polymerase, dis1Δ, we find that both kinesin-8 and Dis1 synergistically negatively regulate pre-anaphase and anaphase A spindle elongation but promote bipolar kinetochore-microtubule attachments in distinct ways. The activity of both factors is required to prepare metaphase for a timely and concerted anaphase for high fidelity chromosome segregation
Serum biomarkers for detection of breast cancers: a prospective study
- Author
- AA Thike
- AM Ugnat
- Anne Cromer
- C Laronga
- Carole Mathelin
- Catherine Tomasetto
- Corinne Wendling
- DF Ransohoff
- E Check
- ER Sauter
- F Lumachi
- F Meric-Bernstam
- GV Glinsky
- H Hondermarck
- HJ Bloom
- HJ Issaq
- J Li
- LL Wilson
- M Chung
- M Sant
- Marie- Christine Rio
- MB Gretzer
- PJ Westenend
- PR Srinivas
- RC Stein
- RD Rosenberg
- RJ Simpson
- S Jmor
- S Romain
- SE Pinder
- SE Singletary
- VD Ermilova
- W Liu
- W Tong
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Geoeconomic variations in epidemiology, ventilation management, and outcomes in invasively ventilated intensive care unit patients without acute respiratory distress syndrome: a pooled analysis of four observational studies
- Author
- Aage Christiansen
- Aaradhana Adhikari
- Aaron Venti
- Aayesha Qadeer
- Abdellatif Benslama
- Abigail Beane
- Abu Hena Mostafa Kamal
- Abul Faiz
- Adam B Schlichting
- Adam Bell Bell
- Adenilton M R Ampinelli
- Aditya Uppalapati
- Adrian Donnelly
- Adriana M Fernandez
- Adrien Robine
- Aftab Akhtar
- Agreta Gecaj-Gashi
- Ahmed Farooq
- Ahmed S Al Jabbary
- Ahmet Dilek
- Ahmet Sukru Denker
- Ai Y Hang
- Aiman Tulaimat
- Akihiro Takaba
- Akinori Uchiyama
- Akira Hirata
- Akm Shamsul Alam
- Akut Aytulun
- Alain Combes
- Alain M Dive
- Alain Mercat
- Alain U Alisasis
- Alan Zazu
- Alastair Rose
- Alberto Deicas
- Alec A Tallet Alfonso
- Alejandro A Saez
- Alejandro Ebeid
- Alejandro G Castro
- Alejandro R Bruhn
- Alek Kumar
- Alessandro Bacuzzi
- Alessandro Protti
- Alessia Mattei
- Alex Mcleod
- Alex Morton
- Alexandra Ceniceros-Barros
- Alexandra J Williams
- Alexandra Marcu
- Alexandra Siqueira Colombo
- Alexandre Biasi Cavalcanti
- Alexandre Biasi Cavalcanti
- Alexandre Chan
- Alexandre Demoule
- Alexandre Guilherme Ribeiro de Carvalho
- Alexandre Molin
- Alexandre Molin
- Alexey I Gritsan
- Alfons Arizmendi
- Aline Ascoli
- Alison Ghosh
- Alistair Nichol
- Alistair Roy Roy
- Alma Cani
- Alvaro Ramirez-Gutierrez
- Amadeu Martinez
- Amanda Cowton
- Amanda Krstevski
- Amanda Maria R R de Oliveira
- Amanda Skinner
- Amanda Whileman
- Amine Ali Zeggwagh
- Amine Ali Zeggwagh
- Amy McInerney
- Ana Carolina P Antônio
- Ana Carolina Peçanha
- Ana G França
- Ana M Araujo
- Ana M Pellicer
- Anais Briquet
- Anand Dongre
- Anatole Harrois
- Anders Aneman
- Anders Larsson
- Andre Japiassu
- Andre Luiz Baptiston Nunes
- Andre Luiz Baptiston Nunes
- Andre Vercueil
- Andrea Coppadoro
- Andrea Cortegiani
- Andrea Cortegiani
- Andrea Lombardo
- Andrea N Cracchiolo
- Andrea Tinnirello
- Andreas Barratt-Due
- Andreas W Reske
- Andrej Sribar
- Andrew Bentley
- Andrew Corner
- Andrew Ferguson
- Andrew J Burtenshaw
- Andrey A Gazenkampf
- André Peretti Torelly
- Angela Delsing
- Angela Pinder
- Aniko D Frigyik
- Anil Hormis
- Anil P Hormis
- Anitha Shenoy
- Anna Hunt
- Anna Oscarsson Tibblin
- Anna Rossi
- Anna T Dowling
- Anna Walker
- Anna-Karin Morin
- Anne Adolfsson
- Anne B Guttormsen
- Annop Piriyapatsom
- Antero do Vale Fernandes
- Antoine Pronovost
- Antonino Giarratano
- Antonio Artigas
- Antonio Braschi
- Antonio Carlos Nogueira
- Antonio G Jimenez
- Antonio Jorge Pereira
- Antonio L Ruiz-Aguilar
- Antonio P Nassar Jr
- Antonio Paulo Nassar Junior
- António M Alvarez
- António M Messias
- Aogan C O'Muircheartaigh
- Areef Ahsan
- Areej Javeed
- Ariel Chena
- Arnaud Follin
- Arshad Taqi
- Arvind K Baronia
- Ary Serpa Neto
- Ashley Schomer
- Ashok S Raj
- Asisclo J Villagomez
- Asisclo Villagomez
- Asma Ben Souissi
- Asma Navasakulpong
- Asoka Gunaratne
- Atta Ur Rehman
- Aurelia M Martinho
- Aylin Seven
- Bao H Zhu
- Barbara Brunettini
- Barbara do Cs Martins
- Barrett T Kitch
- Barry Dixon
- Barry Kennedy
- Basak Ceyda Meco
- Batoul Khoundabi
- Beatriz C Tan
- Behzad Nadjm
- Ben Creagh-Brown
- Bernard Goubaux
- Bernhard Holzgraefe
- Bhagyesh Shah
- Bhuvana Krishna
- Bimal Kudavidanage
- Bin Li
- Bingyu Qin
- Bojan Jovanovic
- Boris G Villamagua
- Brenno Cardoso Gomes
- Brigit L Roberts
- Brit Å Sjøbø
- Bruno Franco Mazza
- Bruno Gelée
- Bruno S Oliveira
- Candelaria De Haro
- Carlo A Volta
- Carlo Alberto Volta
- Carlos A Pellegrini
- Carlos Eduardo Barboza
- Carlos Munhoz
- Carlos S Pereira
- Carly Brown
- Carmen Scott
- Carolina Quintana Grijalba
- Carolina S Insaurralde
- Carolina Serra
- Caroline Berghe
- Caroline C MacFie
- Caroline Wreybrown
- Cassia Righy
- Cassiano Teixeira
- Catalina Forteza
- Catherine Plowright
- Cecilia Carbayo-Gorriz
- Cecilia Hermosa
- Ceri E Battle
- Cesar A Cortez
- Cesar Milstein
- Cesar P Pere
- Chamila Pilimatalawwe
- Charlene Bigot
- Charlene Le Moal
- Charlotte Downes
- Chathurani Sigera
- Chern Min Voon
- Cheryl Padilla-Harris
- Chinni Krishna Kasi
- Chloe Hughes
- Christian C Rylander
- Christian Dellera
- Christian Frey
- Christian M Ramirez-Alfaro
- Christian Schlegel
- Christina Whitehead
- Christine Boyd
- Christine Brown
- Christine Ryan
- Christoph Muench
- Christopher J Scott
- Christopher Nutt
- Christopher Smalley
- Christopher Tainter
- Chunting Wang
- Claine Judy
- Clair Harris
- Claire Kaloo
- Claire Matthews
- Claire Miller
- Claire Pegg
- Claire Reynolds
- Clare Bullock
- Clare Mellis
- Clare Mellis
- Claude Guérin
- Claudia A Ortiz
- Claudia R Estrella
- Claudio H Gonçalves
- Claudio Piras
- Claudio Piras
- Claudio Piras
- Colette Seasman
- Colette Seasman
- Colin K Grissom
- Colin Mcarthur
- Colin S Black
- Cora Lavigne Moreira
- Corcoles G Virgilio
- Corinne Leemann-Refondini
- Cristiane Ritter
- Cristiane Tomasi Damiani
- Cristina M Cox
- Cristina Prata Amendola
- Cristina Santos
- Cristina Santos
- Cédric Daubin
- Daisuke Niimi
- Dale J Yeatts
- Dalton de Souza Barros
- Damien Roux
- Dan E Corneci
- Dan Hadfield
- Dana R Tomescu
- Daniel Aragão
- Daniel Beraldo
- Daniel Collins
- Daniel da Cunha Ribeiro
- Daniel F McAuley
- Daniel Hadfield
- Daniel Hull
- Daniel O Beraldo
- Daniel Prado
- Daniel R Crouch
- Daniel R Gonzalez
- Daniel V Collins
- Daniela Albiero
- Daniela M Palma
- Daniela N Vasquez
- Daniele M Combaux
- Danielle A Fawkes
- Danielle C Fontenele
- Danielle J Hacking
- Danielle Nobrega
- Danielle Reuter
- Danny McAuley
- Dany Goldgran-Toledano
- Dat Vu Quoc
- Davi Cristovao
- David D Llinares Moya
- David Pogson
- David Rogerson
- David Shaw
- David W Wrathall
- Davide D'Antini
- Dawn Trodd
- Debabrata Banik
- Debbie Weller
- Deborah M Inskip
- Deborah Smith
- Deborah Wilson
- Deeban Ganesan
- Demet Aydin
- Denis Doyen
- Denise Donaldson
- Denise Griffin
- Dharshinie Dorasamy
- Diego Pastor Marcos
- Dimitrios Matamis
- Dina Gomaa
- Dina Gomaa
- Dina Ismail
- Dk Maizatul Aiman B Pg Hj Ismail
- Donald A Irvine
- Donall O'Croinin
- Donatella Mestria
- Dora Mannarino
- Dorel Sandesc
- Dorothy M Breen
- Dorothée Carpentier
- Dulce M Dector
- Dyanne Moysés Dalcomune
- Dácil Parrilla Toribio
- Ed Bajwa
- Eddy Fan
- Edel A Meaney
- Edgardo E Tabhan
- Edgardo Nuñez
- Edgardo Tabhan
- Edison Moraes
- Eduardo Beck
- Eduardo Di Lauro
- Eduardo F Labarca
- Eimhin S Dunne
- Eizo Watanabe
- Elaine Ferreira
- Eldar Søreide
- Electra E Stamou
- Elena Frati
- Elena Gallego Curto
- Elena Perez Losada
- Eleni K Mouloudi
- Eleni V Massa
- Eliana Bernadete Caser
- Eliane Bernadete Caser
- Elie H Zogheib
- Eliezer Silva
- Elisa Estenssoro
- Elisa Seghelini
- Elisabetta Pecci
- Elise P Sauvadet
- Ellada V Kiourtzieva
- Elton Afonso Lopes
- Emanuel Cirstea
- Emilio M Osman
- Emma L Willett
- Emre Erbabacan
- Enrique A Piacentini
- Enrique Cereijo
- Eoin Young
- Erika E Borotto
- Erin Nishikawa
- Erna Alberts
- Esther Bermejo Lopez
- Esther Diaz-Rodriguez
- Ettore R Vascotto
- Eva O Nagy
- Evangelos Kalaitzis
- Evelin Drociunas Pacheco
- Evgeny Grigoriev
- Evren Senturk
- Ewan C Goligher
- Fa C Zhou
- Fabien Grelon
- Fabienne D Simonis
- Fabienne D Simonis
- Fabio Tarantino
- Fabrice Daviaud
- Fahd Amir
- Fan Zhang
- Farah Idrees
- Farooq Brohi
- Farshad Heidari
- Fatma Ulger
- Fayez M Kheir
- Feda Kahveci
- Federico Gordo
- Fekri Abroug
- Felipe A Aliaga
- Felipe Dal-Pizzol
- Felipe Saddy
- Felipe T Martinez
- Ferdinando Raimondi
- Fernanda Eugênia Fernandes
- Fernando Borges Rodriguez
- Fernando G George
- Fernando José da Silva Ramos
- Fernando Rios
- Ferran Roche-Campo
- Filipa M Barros
- Finn H Andersen
- Flavia A Loiacono
- Flavia Ribeiro Machado
- Francesco L Santoli
- Francesco Mojoli
- Francesco Raponi
- Francis Schneider
- Francisca G Cazorla-Barranquero
- Francisco Esteve
- Francisco Javier Flores Mejia
- Francisco P Huerta
- Francisco Soriano
- Francois Beloncle
- Frank Stansil
- Frank Van Haren
- Frank Van Haren
- Frantz Berkelmans
- Frederico Bruzzi Carvalho
- Fredrik Schiöler
- Fredy A Montes Oscanoa
- Fredy S Lora
- Fumihito Ito
- Fábio Poianas Giannini
- Gabriel Démpaire
- Gabriele Sales
- Gabrielle C Hanlon
- Gaetan Béduneau
- Galen Henderson
- Garcia M Elisabet
- Gareth P Sellors
- Gary H Mills
- Gautier Buzancais
- Gayle Clifford
- Ged Dempsey
- Gemma Rialp
- Gerard Curley
- Ghaleb Almekhlafi
- Ghanem M Mustafa
- Ghassan Kamel
- Giacomo Bellani
- Giacomo Monti
- Gianluca Zani
- Giannis A Zacharas
- Gilda Cinnella
- Giorgio A Iotti
- Giovana Colozza Mecatti
- Giovanna Occhipinti
- Giovanna Panarello
- Giulia Crapelli
- Giuseppe Foti
- Giuseppe Melchionda
- Gonzalo Navarro
- Greet Hermans
- Guilherme Schettino
- Guillaume Barberet
- Guillaume Carteaux
- Guillermo Bugedo
- Guillermo M Albaiceta
- Gulay Eren
- Gustavo A Plotnikow
- Gustavo Affonso de Oliveira
- Gustavo M Montanha
- Gustavo Pittini
- Guy M Francois
- Gyan Kayashta
- Gyorgy Frendl
- Güldem Turan
- Ha Nguyen Thi Thanh
- Haibo Qiu
- Haibo Qiu
- Haitao Liu
- Hamidreza Jamaati
- Hanane Ezzouine
- Hannah Crowther
- Hans Kedelv
- Hans-Bernd F Hopf
- Hasan M Al Dorzi
- Hazel Spencer
- Heather Blaylock
- Hector H Leon Yoshido
- Heera L Mahto
- Heidi Dawson
- Hektor Sula
- Helen E Ellis
- Helen Green Green
- Helen J Rodgers
- Helen Robertson
- Helen Rodgers
- Helen S Wong
- Helen Talbot
- Helen Wong
- Helena Barcraft-Barnes
- Helga Ceunen
- Helga Ceunen
- Hellen M Van Wezel
- Henrik Appelberg
- Henrik Reschreiter
- Henrik Reschreiter
- Hermann Wrigge
- Hermann Wrigge
- Hernan Aguirre-Bermeo
- Hernan Gianinetto
- Herve Dupont
- Herve Lebbinck
- Hervé O Zender
- Hicham Balkhi
- Hiroki N Maeyama
- Hiroshi Imai
- Hiroyasu Kimura
- Hiroyuki Honda
- Hiroyuki Suzuki
- Hiroyuki Tanaka
- Hitesh Batra
- Hua X Wang
- Huanzhang Shao
- Hui Han
- Huiying Zhao
- Hulya Ulusoy
- Huseyin Toman
- Hélder Konrad de Melo
- Iain McCullagh
- Ian White
- Ichiko Mizuguchi
- Ilaria Pattarino
- Ilkay Ceylan
- Imed Chouchene
- Imo Aisiku
- Ingeborg D Welters
- Ingeborg Welters
- Ingela Nygren
- Ingrid van den Hul
- Iqbal Memon
- Irene M Bailey
- Isabel M Serra
- Isabela Ambrósio Gava
- Isabelle Reed
- Isil Kose
- Islem Ouanes
- Israel Maia
- Istvan Kajtor
- Jack R Richecoeur
- Jack Steinberg
- Jacob S Yumha
- Jacques Duranteau
- Jade M Cole
- Jaime E Solis-Quesada
- Jakob Gjedsted
- James Limb
- Jan Máca
- Jan Máca
- Janaki Arumoli
- Jane Adderly
- Jane Hunt
- Jane Martin
- Jane Montgomery
- Jane Snell
- Janet S Aguirre
- Jarone Lee
- Jason E Cohen
- Javier Alvarez
- Javier Blanco
- Javier E Salas
- Javier G Alonso
- Javier Hurtado
- Javier Hurtado
- Javier Hurtado
- Jean Dellamonica
- Jean Salgado
- Jean-Daniel Chiche
- Jean-Etienne Herbrecht
- Jean-Michel Arnal
- Jean-Philippe Rigaud
- Jennene J Miller
- Jennifer C Goodson
- Jenny Knoll
- Jenny Ritzema
- Jens Kraßler
- Jeremy Bewley
- Jeremy R Beitler
- Jeroen A Schouten
- Jerome Biehler
- Jessica Warren
- Jesús Sánchez-Ballesteros
- Jian Liu
- Jignesh Shah
- Jing Kong
- Jing L Liu
- Joan M Lynch
- Joana M Estilita
- Joanna Wessbergh
- Joanne B Robles
- Joanne Howe
- Johan Decruyenaere
- Johan Helleberg
- Johanna E Citalán
- Johanna Mouland
- Johanna Stickley
- Johannes Mellinghoff Mellinghoff
- John C Adams
- John Criswell
- John Knighton
- John Laffey
- John Neal
- John O Shinn Iii
- Jon Bramall
- Jon H Laake
- Jon Henrik Laake
- Jon P Careless
- Jonas I Rosa
- Jonas Nielsen
- Jonas Nielsen
- Jonathan Casement
- Jonathan Chelly
- Jonathan Cooper
- Jonathan Harrison
- Jonathan M Fierro
- Jonathan Messika
- Jonathan Paddle
- Jordana S Lemus
- Jordi Mancebo
- Jorge Luis Ranero
- Jorge M Monteiro
- Jorge R Sanchez-Medina
- Jorge Salluh
- Joris Vermassen
- Jose A Lorente
- Jose Augusto Santos Pellegrini
- Jose Emmanuel Palo
- Joseph Needleman
- Josette Gally
- Josè Aires Neto
- José Carlos Fernandez Versiani Dos Anjos
- Juan A Buensuseso
- Juan Alfonso Soler
- Juan B López-Messa
- Juan C Lopez-Delgado
- Juan Carlos J Sotillo Diaz
- Juan I Silesky Jimenez
- Juan Silesky
- Juanhong Shen
- Julian Giles
- Juliana Baroni Fernandes
- Juliana Carvalho Ferreira
- Juliano Pinheiro de Almeida
- Julie Camsooksai
- Julie Camsooksai
- Julie Furneval Furneval
- Julie Toms
- Julien Marin
- Julio C Badie
- Julio Daldin
- Julius H Cranshaw
- Jun Zhao
- Junping Qin
- Juçara Gasparetto Maccari
- Kai Chen
- Kai D Zacharowski
- Kanishka Indraratna
- Kanokkarn Juntaping
- Kansuke Koyama
- Karen Burt
- Karen E Williams
- Karen Simeson
- Karen Williams
- Karin E Eriksson
- Karina Jakubowska
- Karjbundid Surasit
- Karl Blenk
- Karl M Knapman
- Karla Loureiro Meira
- Kate Turner
- Katharina C Riss
- Katie H Mccalman
- Katie Lynch
- Katie Sweet
- Katsunori Mochizuki
- Kaushik Bhowmick
- Kaushila Thilakasiri
- Kaweesak Chittawatanarat
- Kazuya Ichikado
- Kazuyoshi Shimizu
- Keiko Ueno
- Keith D Lamb
- Keith Hugill
- Kelly Matthews
- Ken Parhar
- Kenichi Nitta
- Kesharie De Silva
- Kessia Ruas
- Kevin Clarkson
- Kevin Clarkson
- Kevin P Clarkson
- Khalid A Maghrabi
- Kim Andre L Noremark
- Kim S Zantua
- Kinh Nguyen Van
- Kiyoyasu Kurahashi
- Kobus Preller
- Kohei Kusumoto
- Kohkichi Andoh
- Koji Saito
- Kong Y Liew
- Konlawij Trongtrakul
- Kristen Joyce
- Kumudini Ranatunge
- Kyle G Davies
- Kyle R Dreyer
- Kyoko Shiozaki
- Lakshman Dissanayake
- Lars Hedlund
- Lars M Broman
- Latha Srinivasa
- Laura Alvarez Montero
- Laura Claverias
- Laura Ortiz-Ruiz
- Laura Ortiz-Ruiz De Gordoa
- Laura Youds
- Laurence Dangers
- Laurent Papazian
- Leanlove Navarra
- Leda Floris
- Lee Tbaily
- Leo M Heunks
- Leo M Heunks
- Leonardo de Assis Simões
- Leticia Seoane-Quiroga
- Li Ling Tai
- Lia McNamee
- Lia McNamee
- Liangyan Jiang
- Lilian Batista Nunes
- Lilian Tanaka
- Linda Twohey
- Ling Liu
- Linnea Persson
- Lisa Barrell
- Lisa Grimmer
- Lisandro R Bettini
- Lise Piquilloud
- Lise Piquilloud
- Livia Leal
- Lokman Soyoral
- Long L Ling
- Loranthi Samarasinghe
- Lordian Nunci
- Loredana Baboi
- Lorenzo Peluso
- Lorenzo Schiavoni
- Lorna Murray Murray
- Lorraine Stephenson
- Lotta Niska
- Louise Aline Romão Gondim
- Louise Thwaites
- Louise Tonks
- Lousie Fasting Fasting
- Luana Tannous
- Luc DeCrop
- Luca Brazzi
- Luca Brazzi
- Luca M Montini
- Lucas Oliveira
- Lucia L Rodriguez
- Lucia Mirabella
- Luciana Coelho Sanches
- Luciano C Azevedo
- Luciano Cesar Azevedo
- Lucy Cooper
- Ludhmila Hajjar
- Luis A Sanchez-Hurtado
- Luis D Vega
- Luis E Avila
- Luis Fernando Falcão
- Luis Herrera Para
- Luis J Yuste
- Luis M Claraco-Vega
- Luis Marcelo Malbouisson
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- Seyed Mohammadreza Hashemian
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- Shivakumar Iyer
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- Shunsuke Takagi
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- Silvia Iglesias Moles
- Silvia L Nunes
- Silvia Rodriguez Ruiz
- Silvina A Borello
- Silvio A Ñamendys-Silva
- Silvius Ioan Negoita
- Simon K Chau
- Sinead C Okane
- Siti Nur Suhaila Azauddin
- Siu-Ming Au
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- Suleyman S Derman
- Suming Zhou
- Sunisa Chatmongkolchart
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- Suresh Shindhe
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- Sánchez I Rafael
- Sébastien Jochmans
- Sérgio Felix Pinto
- Sílvia Moulin
- T John Trinder
- T Sottiaux
- Tadaaki Takada
- Tai Pham
- Takeshi Ueda
- Tamas Szakmany
- Tananchai Petnak
- Tanja A Treschan
- Tanveer Hussain
- Tao Yu
- Taohidul Majid Taohid
- Tarek Dendane
- Tarikul Hamid
- Tasmin Patel
- Tatjana Simurina
- Teresa Honrubia
- Terri-Ann Sewell
- Tharwat M Aisa
- Theonymfi G Papavasilopoulou
- Thiago Lisboa
- Thomas Baltus
- Thomas C Blakeman
- Thomas Collyer
- Thomas Kander
- Thomas Staudinger
- Thuy Duong Bich
- Théia Forny Wanderley Castellões
- Tiago Macruz
- Tie H Qin
- Tim Wenham
- Tom Hatton
- Tomas P Roser
- Tomaz Mesar
- Tomaz Mesar
- Tommaso Fossali
- Tomoaki Hashida
- Tomofumi Harasawa
- Tomoyuki Nakamura
- Toni E Mckenna
- Toshikazu Abe
- Tracey Evans
- Trevor W Oetting
- Troy S B Rowne
- Tài Pham
- Udomsak Silachamroon
- Ugur Goktas
- Ulysses V A Silva
- Una Poultney
- Unase Buyukkocak
- Upeka Samaranayake
- Ushio Higashijima
- Valeria I Cerrato
- Valerie M Banner-Goodspeed
- Vallish K Bhardwaj
- Vallverdu P Imma
- Valéria Maria Campos Rezende
- Vanessa Linnett
- Vanessa M Sales
- Vanessa Oliveira
- Vania A Brito
- Varsha Kadaba
- Vasilis Ourailogloy
- Venika Manoharan
- Venkatapura J Ramesh
- Veronica Villar
- Vesna Bumbasierevic
- Vesna Bumbasirevic
- Vicente Cés de Souza Dantas
- Vijayanand Palaniswamy
- Vincenzo Pota
- Vincenzo Russotto
- Vincenzo Schiavone
- Viratch Tangsujaritvijit
- Virginie Lemiale
- Visanthi Pinto
- Vivek Kakar
- Vladimir Cerny
- Vlasta Klaric
- Wahid Altaf
- Wajdi Maazouzi
- Wei H Zhu
- Wei Wang
- Weihua Lu
- Wenkui Yu
- Wenwen Li
- Werner Schmid
- William Stigler
- Xavier Wittebole
- Xian Y Zhao
- Xiao B Huang
- Xiao L Li
- Xiaoming Luo
- Xing Y Zhang
- Xinyu Li
- Y A Hasitha Dilhani
- Ya Q Wu
- Yaasen Arabi
- Yan Gao
- Yaseen M Arabi
- Yasuaki Ogino
- Yavuz Orak
- Yen Lam Minh
- Yi Han
- Yimin Li
- Yonghao Xu
- Yoshihiro Yamaji
- Yoshinobu Kameyama
- Youssef Haddad
- Youzhong An
- Yozo Kashiwa
- Yu D Di
- Yuan N Gao
- Yuan Y Li
- Yuanhua Lu
- Yves D Jarquin-Badiola
- Zerrin Demirtürk
- Zhe Zhai
- Zheng L Ye
- Zhenyang He
- Zhou Li-Xin
- Álvaro Réa-Neto
- Ángela Algaba
- Ángela González-Salamanca
- Çiler Zincircioglu
- Érica Aranha Suzumura
- Ênio Rego
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
Background: Geoeconomic variations in epidemiology, the practice of ventilation, and outcome in invasively ventilated intensive care unit (ICU) patients without acute respiratory distress syndrome (ARDS) remain unexplored. In this analysis we aim to address these gaps using individual patient data of four large observational studies.
Methods: In this pooled analysis we harmonised individual patient data from the ERICC, LUNG SAFE, PRoVENT, and PRoVENT-iMiC prospective observational studies, which were conducted from June, 2011, to December, 2018, in 534 ICUs in 54 countries. We used the 2016 World Bank classification to define two geoeconomic regions: middle-income countries (MICs) and high-income countries (HICs). ARDS was defined according to the Berlin criteria. Descriptive statistics were used to compare patients in MICs versus HICs. The primary outcome was the use of low tidal volume ventilation (LTVV) for the first 3 days of mechanical ventilation. Secondary outcomes were key ventilation parameters (tidal volume size, positive end-expiratory pressure, fraction of inspired oxygen, peak pressure, plateau pressure, driving pressure, and respiratory rate), patient characteristics, the risk for and actual development of acute respiratory distress syndrome after the first day of ventilation, duration of ventilation, ICU length of stay, and ICU mortality.
Findings: Of the 7608 patients included in the original studies, this analysis included 3852 patients without ARDS, of whom 2345 were from MICs and 1507 were from HICs. Patients in MICs were younger, shorter and with a slightly lower body-mass index, more often had diabetes and active cancer, but less often chronic obstructive pulmonary disease and heart failure than patients from HICs. Sequential organ failure assessment scores were similar in MICs and HICs. Use of LTVV in MICs and HICs was comparable (42·4% vs 44·2%; absolute difference -1·69 [-9·58 to 6·11] p=0·67; data available in 3174 [82%] of 3852 patients). The median applied positive end expiratory pressure was lower in MICs than in HICs (5 [IQR 5-8] vs 6 [5-8] cm H2O; p=0·0011). ICU mortality was higher in MICs than in HICs (30·5% vs 19·9%; p=0·0004; adjusted effect 16·41% [95% CI 9·52-23·52]; p<0·0001) and was inversely associated with gross domestic product (adjusted odds ratio for a US$10 000 increase per capita 0·80 [95% CI 0·75-0·86]; p<0·0001).
Interpretation: Despite similar disease severity and ventilation management, ICU mortality in patients without ARDS is higher in MICs than in HICs, with a strong association with country-level economic status
Search for Scalar Diphoton Resonances in the Mass Range 65−600 GeV with the ATLAS Detector in pp Collision Data at s = 8 TeV
- Author
- Aad Georges
- Abbott Brad
- Abdallah Jalal
- Abdel Khalek Samah
- Abdinov Ovsat
- Aben Rosemarie
- Abi Babak
- AbouZeid Ossama
- Abramowicz Halina
- Abreu Henso
- Abreu Ricardo
- Abulaiti Yiming
- Acharya Bobby Samir
- Adamczyk Leszek
- Adams David
- Adelman Jahred
- Adomeit Stefanie
- Adye Tim
- Agatonovic-Jovin Tatjana
- Aguilar-Saavedra Juan Antonio
- Agustoni Marco
- Ahlen Steven
- Ahmadov Faig
- Aielli Giulio
- Akerstedt Henrik
- Akimoto Ginga
- Akimov Andrei
- Alberghi Gian Luigi
- Albert Justin
- Albrand Solveig
- Alconada Verzini Maria Josefina
- Aleksa Martin
- Aleksandrov Igor
- Alexa Calin
- Alexander Gideon
- Alexandre Gauthier
- Alexopoulos Theodoros
- Alhroob Muhammad
- Alimonti Gianluca
- Alio Lion
- Alison John
- Allbrooke Benedict
- Allison Lee John
- Allport Phillip
- Aloisio Alberto
- Alonso Alejandro
- Alonso Francisco
- Alpigiani Cristiano
- Altheimer Andrew David
- Alvarez Gonzalez Barbara
- Alviggi Mariagrazia
- Amaral Coutinho Yara
- Amelung Christoph
- Amidei Dante
- Amor Dos Santos Susana Patricia
- Amoroso Simone
- Amram Nir
- Amundsen Glenn
- Anastopoulos Christos
- Ancu Lucian Stefan
- Andari Nansi
- Andeen Timothy
- Anders Christoph Falk
- Anders Gabriel
- Anderson Kelby
- Andreazza Attilio
- Andrei George Victor
- Anduaga Xabier
- Angelidakis Stylianos
- Angelozzi Ivan
- Anger Philipp
- Angerami Aaron
- Anisenkov Alexey
- Anjos Nuno
- Annovi Alberto
- Antonaki Ariadni
- Antonelli Mario
- Antonov Alexey
- Antos Jaroslav
- Anulli Fabio
- Aoki Masato
- Aperio Bella Ludovica
- Apolle Rudi
- Arabidze Giorgi
- Aracena Ignacio
- Arai Yasuo
- Araque Juan Pedro
- Arce Ayana
- Arduh Francisco Anuar
- Arguin Jean-Francois
- Argyropoulos Spyridon
- Arik Metin
- Armbruster Aaron James
- Arnaez Olivier
- Arnal Vanessa
- Arnold Hannah
- Arratia Miguel
- Arslan Ozan
- Artamonov Andrei
- Artoni Giacomo
- Asai Shoji
- Asbah Nedaa
- Ashkenazi Adi
- Asquith Lily
- Assamagan Ketevi
- Astalos Robert
- Atkinson Markus
- ATLAS Collaboration
- Atlay Naim Bora
- Auerbach Benjamin
- Augsten Kamil
- Aurousseau Mathieu
- Avolio Giuseppe
- Azuelos Georges
- Azuma Yuya
- Baak Max
- Baas Alessandra
- Bachacou Henri
- Bachas Konstantinos
- Backes Moritz
- Backhaus Malte
- Backus Mayes John
- Badescu Elisabeta
- Bagiacchi Paolo
- Bagnaia Paolo
- Bai Yu
- Bain Travis
- Baines John
- Baker Oliver Keith
- Balek Petr
- Balli Fabrice
- Banas Elzbieta
- Banerjee Swagato
- Bannoura Arwa A E
- Bansil Hardeep Singh
- Barak Liron
- Barberio Elisabetta Luigia
- Barberis Dario
- Barbero Marlon
- Barillari Teresa
- Barisonzi Marcello
- Barklow Timothy
- Barlow Nick
- Barnes Sarah Louise
- Barnett Bruce
- Barnett Michael
- Barnovska Zuzana
- Baroncelli Antonio
- Barone Gaetano
- Barr Alan
- Barreiro Guimarães da Costa João
- Barreiro Fernando
- Bartoldus Rainer
- Barton Adam Edward
- Bartos Pavol
- Bartsch Valeria
- Bassalat Ahmed
- Basye Austin
- Bates Richard
- Batley Richard
- Battaglia Marco
- Battistin Michele
- Bauer Florian
- Bawa Harinder Singh
- Beattie Michael David
- Beau Tristan
- Beauchemin Pierre-Hugues
- Bechtle Philip
- Beck Hans Peter
- Becker Anne Kathrin
- Becker Sebastian
- Beckingham Matthew
- Becot Cyril
- Beddall Andrew
- Beddall Ayda
- Bedikian Sourpouhi
- Bednyakov Vadim
- Bee Christopher
- Beemster Lars
- Beermann Thomas
- Begel Michael
- Behr Katharina
- Belanger-Champagne Camille
- Bell Paul
- Bell William
- Bella Gideon
- Bellagamba Lorenzo
- Bellerive Alain
- Bellomo Massimiliano
- Belotskiy Konstantin
- Beltramello Olga
- Benary Odette
- Benchekroun Driss
- Bendtz Katarina
- Benekos Nektarios
- Benhammou Yan
- Benhar Noccioli Eleonora
- Benitez Garcia Jorge-Armando
- Benjamin Douglas
- Bensinger James
- Bentvelsen Stan
- Berge David
- Bergeaas Kuutmann Elin
- Berger Nicolas
- Berghaus Frank
- Beringer Jürg
- Bernard Clare
- Bernat Pauline
- Bernius Catrin
- Bernlochner Florian Urs
- Berry Tracey
- Berta Peter
- Bertella Claudia
- Bertoli Gabriele
- Bertolucci Federico
- Bertsche Carolyn
- Bertsche David
- Besana Maria Ilaria
- Besjes Geert-Jan
- Bessidskaia Olga
- Bessner Martin Florian
- Besson Nathalie
- Betancourt Christopher
- Bethke Siegfried
- Bhimji Wahid
- Bianchi Riccardo-Maria
- Bianchini Louis
- Bianco Michele
- Biebel Otmar
- Bieniek Stephen Paul
- Bierwagen Katharina
- Biesiada Jed
- Biglietti Michela
- Bilbao De Mendizabal Javier
- Bilokon Halina
- Bindi Marcello
- Binet Sebastien
- Bingul Ahmet
- Bini Cesare
- Black Curtis
- Black James
- Black Kevin
- Blackburn Daniel
- Blair Robert
- Blanchard Jean-Baptiste
- Blazek Tomas
- Bloch Ingo
- Blocker Craig
- Blumenschein Ulrike
- Bobbink Gerjan
- Bobrovnikov Victor
- Bocchetta Simona Serena
- Bocci Andrea
- Bock Christopher
- Boddy Christopher Richard
- Boehler Michael
- Boek Thorsten Tobias
- Bogdanchikov Alexander
- Bohm Christian
- Boisvert Veronique
- Bold Tomasz
- Boldyrev Alexey
- Bomben Marco
- Bona Marcella
- Boonekamp Maarten
- Borisov Anatoly
- Borissov Guennadi
- Borri Marcello
- Borroni Sara
- Bortfeldt Jonathan
- Bortolotto Valerio
- Boscherini Davide
- Bosman Martine
- Boterenbrood Hendrik
- Boudreau Joseph
- Bouffard Julian
- Bouhova-Thacker Evelina Vassileva
- Boumediene Djamel Eddine
- Bourdarios Claire
- Bousson Nicolas
- Boutouil Sara
- Boveia Antonio
- Boyd James
- Boyko Igor
- Bozic Ivan
- Bracinik Juraj
- Brandt Andrew
- Brandt Gerhard
- Brandt Oleg
- Bratzler Uwe
- Brau Benjamin
- Brau James
- Brazzale Simone Federico
- Brelier Bertrand
- Brendlinger Kurt
- Brennan Amelia Jean
- Brenner Richard
- Bressler Shikma
- Bristow Kieran
- Bristow Timothy Michael
- Britton Dave
- Brochu Frederic
- Brock Ian
- Brock Raymond
- Bronner Johanna
- Brooijmans Gustaaf
- Brooks Timothy
- Brooks William
- Brosamer Jacquelyn
- Brost Elizabeth
- Brown Jonathan
- Bruckman de Renstrom Pawel
- Bruncko Dusan
- Bruneliere Renaud
- Brunet Sylvie
- Bruni Alessia
- Bruni Graziano
- Bruschi Marco
- Bryngemark Lene
- Buanes Trygve
- Buat Quentin
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- Tibbetts Mark James
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- Timoshenko Sergey
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- Yildirim Eda
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- Yoosoofmiya Reza
- Yorita Kohei
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- Yoshihara Keisuke
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- Young Christopher John
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- Yu Jaehoon
- Yu Jiaming
- Yu Jie
- Yuan Li
- Yurkewicz Adam
- Yusuff Imran
- Zabinski Bartlomiej
- Zaidan Remi
- Zaitsev Alexander
- Zaman Aungshuman
- Zambito Stefano
- Zanzi Daniele
- Zeitnitz Christian
- Zeman Martin
- Zemla Andrzej
- Zengel Keith
- Zenin Oleg
- Zerwas Dirk
- Zevi della Porta Giovanni
- Zhang Dongliang
- Zhang Fangzhou
- Zhang Jinlong
- Zhang Lei
- Zhang Ruiqi
- Zhang Xueyao
- Zhang Zhiqing
- Zhao Yongke
- Zhao Zhengguo
- Zhemchugov Alexey
- Zhong Jiahang
- Zhou Bing
- Zhou Lei
- Zhou Ning
- Zhu Cheng Guang
- Zhu Hongbo
- Zhu Junjie
- Zhu Yingchun
- Zhuang Xuai
- Zhukov Konstantin
- Zibell Andre
- Zieminska Daria
- Zimine Nikolai
- Zimmermann Christoph
- Zimmermann Robert
- Zimmermann Simone
- Zimmermann Stephanie
- Zinonos Zinonas
- Ziolkowski Michael
- Zobernig Georg
- Zoccoli Antonio
- zur Nedden Martin
- Zurzolo Giovanni
- Zutshi Vishnu
- Zwalinski Lukasz
- Åkesson Torsten Paul Ake
- Åsman Barbro
- Ženiš Tibor
- Publication venue
- Publication date
- 01/01/2014
- Field of study
A search for scalar particles decaying via narrow resonances into two photons in the mass range 65–600 GeV is performed using 20.3fb−1 of s=8TeV pp collision data collected with the ATLAS detector at the Large Hadron Collider. The recently discovered Higgs boson is treated as a background. No significant evidence for an additional signal is observed. The results are presented as limits at the 95% confidence level on the production cross section of a scalar boson times branching ratio into two photons, in a fiducial volume where the reconstruction efficiency is approximately independent of the event topology. The upper limits set extend over a considerably wider mass range than previous searches