Karijesprotektivni učinak zubne paste koja sadržava teobromin na karijes u ranoj dječjoj dobi: preliminarni rezultati

Objective: Enamel remineralizing effects of theobromine have received much attention from the clinicians. The aim of this study was to investigate the caries preventive effect of theobromine containing toothpaste on children with early childhood caries (ECC). Materials & Methods: Salivary pH, buffering capacity and frequency of Streptococcus mutans (SM) levels were measured. Each child was assigned either fluoridated or theobromine containing toothpaste. The changes were analyzed using Laser Fluorescence system. Statistical analyses were performed. Results: We included 13 children (mean age 4.25) with 145 teeth in the fluoridated toothpaste (Colgate Kids toothpaste) group; 13 children (mean age 4.46) with 115 teeth in theobromine containing toothpaste (Theodent TM Kids toothpaste) group. Both toothpastes demonstrated enamel remineralization and were effective in increasing the buffering capacity and pH (p < 0.05). A statistically significant decrease in S. mutans levels was found in both toothpaste groups (p<0.05). Conclusion: Both toothpaste group showed a statistically significant amount of enamel remineralization. Since theobromine had the added benefits of increasing the salivary pH and decreasing the S.mutans levels, theobromine containing toothpastes can be considered effective agents in remineralizing white spot lesions and can be used in prevention of early enamel lesions.Svrha rada: Učinci teobromina na remineralizaciju cakline privukli su pozornost kliničara. Cilj ovog istraživanja bio je istražiti karijesprotektivni učinak paste za zube koja sadržava teobromin na karijes u ranoj dječjoj dobi. Materijal i metode: Izmjereni su pH sline, puferski kapacitet i razina bakterija Streptococcus mutans. Svakom djetetu dodijeljena je zubna pasta s fluorom ili teobrominom. Promjene su analizirane s pomoću laserskoga fluorescentnog sustava. Obavljene su statističke analize. Rezultati: U skupinu s fluoriranom zubnom pastom (Colgate Kids) bilo je uključeno 13 djece (prosječna dob 4,25) sa 145 zuba; u skupini sa zubnom pastom koja sadržava teobromin (TheodentT-MKids) sudjelovalo je 13 djece (prosječna dob 4,46) sa 115 zuba. Obje zubne paste potaknule su remineralizaciju cakline i učinkovito su povećale puferski kapacitet i pH (p < 0,05). U objema skupinama ustanovljeno je statistički značajno smanjenje razine S. mutans (p < 0,05). Zaključak: Obje zubne paste imale su statistički značajan učinak na remineralizaciju cakline. Budući da su kod teobromina zabilježene dodatne prednosti poput povećanja pH sline i smanjenja razine S. mutans, paste za zube koje sadržavaju teobromin mogu se smatrati učinkovitim sredstvom za remineralizacije bijelih mrlja i mogu se upotrebljavati u prevenciji ranih lezija cakline

The effect of a novel toothpaste in children with white spot lesions

Objective: To investigate the effect of a novel mineral containing toothpaste in comparison to a fluoride toothpaste in children with white spot lesions. Method: The clinical study was conducted from 2016 to 2018 at Marmara University Department of Pediatric Dentistry Clinic after approval from the ethics review committee of Yeditepe University, Istanbul, Turkey, and comprised children of either gender aged 4-5 years having white spot lesions. They were randomly allocated into two groups. The FT ( Fluoridated Toothpaste ) group was given a 500ppm fluoridated toothpaste, while the Mineral Containing Toothpaste (MCT) group was given toothpaste containing calcium glycerophosphate, magnesium chloride, and 12% xylitol. The white spot lesions were examined using Laser Fluorescence (LF) at baseline and after a month of usage. The two readings were compared. Stimulated saliva was collected for measuring the salivary potential of hydrogen, buffering capacity, and streptococcus mutans. Data was analysed using SPSS 19. Results: Of the 26 children, 10(38%) were girls and 16(62%) were boys. The overall mean age was 4.77+/-0.54 years. There were 13(50%) subjects in each of the two groups. Of the 381 measurements done, 198(52%) were in the MCT group and 183(48%) in the FT group. LF scores decreased in both the groups (p=0.001). The remineralising potential was not significantly different (p=0.866), while salivary buffering capacity and potential of hydrogen increased in both the groups but the change was not significant (p>0.05).  The number of children positive for streptococcus mutans decreased in both the groups (p>0.05). ---Continu