Improved flexibility and equity for airspace users during demand-capacity imbalance - an introduction to the user-driven prioritisation process

ATFM slot-swapping represents the first step towards the participation of airspace users (AUs) in air traffic management and airport collaborative processes. SESAR is advancing this through development of the user driven prioritisation process (UDPP) to achieve additional flexibility for AUs to adapt their operations in a more cost-efficient manner in the presence of unforeseen demand and capacity imbalances that require the application of delays to flights. The contribution of this paper is twofold: (i) to present the challenges achieved so far with respect to UDPP concepts, in particular regarding fleet delay apportionment and selective flight protection; (ii) to pave the way towards future UDPP concepts through the introduction of enhanced selective flight protection

Domino D3.1 - Architecture definition

This deliverable presents the concept of operation of Domino. It includes a description of the systems, subsystems and processes that will be taken into account in the model, as well as the general scope of the model. For each of the mechanisms suggested to be modelled in the project, the deliverable provides a set of possible operational concepts and uptake/scope to be deployed

Vegetal diamine oxidase alleviates histamine-induced contraction of colonic muscles

Excess of histamine in gut lumen generates a pronounced gastrointestinal discomfort, which may include diarrhea and peristalsis dysfunctions. Deleterious effects of histamine can be alleviated with antihistamine drugs targeting histamine receptors. However, many antihistamine agents come with various undesirable side effects. Vegetal diamine oxidase (vDAO) might be a relevant alternative owing to its histaminase activity. Mammalian intestinal mucosa contains an endogenous DAO, yet possessing lower activity compared to that of vDAO preparation. Moreover, in several pathological conditions such as inflammatory bowel disease and irritable bowel syndrome, this endogenous DAO enzyme can be lost or inactivated. Here, we tested the therapeutic potential of vDAO by focusing on the well-known effect of histamine on gut motility. Using ex vivo and in vitro assays, we found that vDAO is more potent than commercial anti-histamine drugs at inhibiting histamine-induced contraction of murine distal colon muscles. We also identified pyridoxal 5′-phosphate (the biologically active form of vitamin B6) as an effective enhancer of vDAO antispasmodic activity. Furthermore, we discovered that rectally administered vDAO can be retained on gut mucosa and remain active. These observations make administration of vDAO in the gut lumen a valid alternative treatment for histamine-induced intestinal dysfunctions

Ocorrência dos agentes etiológicos causadores de mastite subclínica em ovelhas das Raças Morada Nova e Santa Inês.

This study aimed to determine the occurrence of the etiologic agents of subclinical mastitis in Santa Inês and Morada Nova ewes and their susceptibility to developing the disease when submitted to the same management conditions. We analyzed 250 mammary glands of 130 Santa Inês ewes and 143 mammary glands of 77 Morada Nova ewes. The California Mastitis Test, somatic cell counts and microbiological analysis were performed at the moment of drying off. The occurrences of subclinical mastitis in different breeds were analyzed using the chi-square test by adjusting the values according to the Yates continuity correction. The infectious subclinical mastitis was present in 33.1% and 35.1% of Santa Inês and Morada Nova ewes, respectively. Among the evaluated mammary glands of Santa Inês ewes, 20.4% had subclinical mastitis with the following infectious etiology: Coagulase-negative Staphylococci (CNS) (46%), Coliforms (22.0%), Streptococcus spp. (12.0%), Corynebacterium spp. (6%), Micrococcus spp. (6.0%), Staphylococcus aureus (2.0%), Coagulase-positive Staphylococci (2.0%) and CNS and Streptococcus spp. (4.0%) mixed infection. Of the Morada Nova ewe mammary glands evaluated, 21% had subclinical mastitis with the following etiologic agents and their occurrences: CNS (56.7%), Coliforms (13.3%), Corynebacterium spp. (10.0%), Staphylococcus aureus (10.0%), Micrococcus spp. (6.7%) and Streptococcus spp. (3.3%). The CNS can be considered the most important etiological agent of subclinical mastitis in sheep. Santa Inês and Morada Nova ewes have the same chances of developing sub-clinical mastitis when subjected to the same management system