Higher dimensional abelian Chern-Simons theories and their link invariants

The role played by Deligne-Beilinson cohomology in establishing the relation between Chern-Simons theory and link invariants in dimensions higher than three is investigated. Deligne-Beilinson cohomology classes provide a natural abelian Chern-Simons action, non trivial only in dimensions $4l+3$, whose parameter $k$ is quantized. The generalized Wilson $(2l+1)$-loops are observables of the theory and their charges are quantized. The Chern-Simons action is then used to compute invariants for links of $(2l+1)$-loops, first on closed $(4l+3)$-manifolds through a novel geometric computation, then on $\mathbb{R}^{4l+3}$ through an unconventional field theoretic computation.Comment: 40 page

Domino D3.1 - Architecture definition

This deliverable presents the concept of operation of Domino. It includes a description of the systems, subsystems and processes that will be taken into account in the model, as well as the general scope of the model. For each of the mechanisms suggested to be modelled in the project, the deliverable provides a set of possible operational concepts and uptake/scope to be deployed

The heavy fermion damping rate puzzle

: We examine again the problem of the damping rate of a moving heavy fermion in a hot plasma within the resummed perturbative theory of Pisarski and Braaten. The ansatz for its evaluation which relates it to the imaginary part of the fermion propagator pole in the framework of a self-consistent approach is critically analyzed. As already pointed out by various authors, the only way to define the rate is through additional implementation of magnetic screening. We show in detail how the ansatz works in this case and where we disagree with other authors. We conclude that the self-consistent approach is not satisfactory.Comment: 17 page

Observation of a warped helical spin-texture in Bi2_2Se3_3 from circular dichroism angle-resolved photoemission spectroscopy

A differential coupling of topological surface states to left- versus right-circularly polarized light is the basis of many opto-spintronics applications of topological insulators. Here we report direct evidence of circular dichroism from the surface states of Bi$_2$Se$_3$ using a laser-based time-of-flight angle-resolved photoemission spectroscopy. By employing a novel sample rotational analysis, we resolve unusual modulations in the circular dichroism photoemission pattern as a function of both energy and momentum, which perfectly mimic the predicted but hitherto un-observed three-dimensional warped spin-texture of the surface states. By developing a microscopic theory of photoemission from topological surface states, we show that this correlation is a natural consequence of spin-orbit coupling. These results suggest that our technique may be a powerful probe of the spin-texture of spin-orbit coupled materials in general.Comment: 16 pages, 4 figure

eIF4A inhibitors suppress cell-cycle feedback response and acquired resistance to CDK4/6 inhibition in cancer

CDK4/6 inhibitors are FDA-approved drugs for estrogen receptor-positive (ER+) breast cancer and are being evaluated to treat other tumor types, including KRAS-mutant non-small cell lung cancer (NSCLC). However, their clinical utility is often limited by drug resistance. Here, we sought to better understand the resistant mechanisms and help devise potential strategies to overcome this challenge. We show that treatment with CDK4/6 inhibitors in both ER+ breast cancer and KRAS-mutant NSCLC cells induces feedback upregulation of cyclin D1, CDK4, and cyclin E1, mediating drug resistance. We demonstrate that rocaglates, which preferentially target translation of key cell-cycle regulators, effectively suppress this feedback upregulation induced by CDK4/6 inhibition. Consequently, combination treatment of CDK4/6 inhibitor palbociclib with the eukaryotic initiation factor (eIF) 4A inhibitor, CR-1-31-B, is synergistic in suppressing the growth of these cancer cells in vitro and in vivo Furthermore, ER+ breast cancer and KRAS-mutant NSCLC cells that acquired resistance to palbociclib after chronic drug exposure are also highly sensitive to this combination treatment strategy. Our findings reveal a novel strategy using eIF4A inhibitors to suppress cell-cycle feedback response and to overcome resistance to CDK4/6 inhibition in cancer.Accepted manuscrip

The protein import apparatus of chloroplasts

Routing of cytosolically synthesized precursor proteins into chloroplasts is a specific process which involves a multitude of soluble and membrane components. In this review we wil1 focus on early events of the translocation pathway of nuclear coded plastidic precursor proteins and compare import routes for polypeptide of the outer chloroplast envelope to that of internal chloroplast compartments. A number of proteins housed in the chloroplast envelopes have been implied to be involved in the translocation process, but so far a certain function has not been assigned to any of these proteins. The only exception could be an envelope localized hsc 70 homologue which could retain the import competence of a precursor protein in transit into the organelle

cloudbandPy 1.0: an automated algorithm for the detection of tropical–extratropical cloud bands

Persistent and organized convective cloud systems that arise in convergence zones can lead to the formation of synoptic cloud bands extending from the tropics to the extratropics. These cloud bands are responsible for heavy precipitation and are often a combination of tropical intrusions of extratropical Rossby waves and processes originating from the tropics. Detecting these cloud bands presents a valuable opportunity to enhance our understanding of the variability of these systems and the underlying processes that govern their behavior and that connect the tropics and the extratropics. This paper presents a new atmospheric cloud band detection method based on outgoing longwave radiation using computer vision techniques, which offers enhanced capabilities to identify long cloud bands across diverse gridded datasets and variables. The method is specifically designed to detect extended tropical–extratropical convective cloud bands, ensuring accurate identification and analysis of these dynamic atmospheric features in convergence zones. The code allows for easy configuration and adaptation of the algorithm to meet specific research needs. The method handles cloud band merging and splitting, which allows for an understanding of the life cycle of cloud bands and their climatology. This algorithm lays the groundwork for improving our understanding of the large-scale processes that are involved in the formation and life cycle of cloud bands and the connections between tropical and extratropical regions as well as evaluating the differences in cloud band types between different ocean basins.</p