Formulation and evaluation of fast disintegrating tablets of Granisetron HCl using natural polymers

The present research work is to formulate and evaluate fast disintegrating tablets of Ganisetron HCl using natural polymers. Tablets were prepared by direct compression method using different drug polymer concentration. Fourier Transform Infrared Spectroscopy (FT-IR) study revealed no chemical interaction between drug and polymers used. Precompression and postcompression parameters were within the limits for the tablets. Disintegration and dissolution data of tablets were directly proportional to the superdisintegrants concentration. Selected fast dissolving tablet F8 containing plantago ovate 5%w/w has released 99.66 % within 3min

Formulation and evaluation of controlled release matrix tablets of antihypertensive drug using natural and synthetic hydrophilic polymers

The present study is to prepare and evaluate controlled release matrix tablets of Losartan potassium using natural and synthetic polymers. Tablets were prepared by direct compression method using different drug: polymer concentration. Fourier Transform Infrared Spectroscopy (FT-IR) and Differential Scanning Calorimetry (DSC) study revealed no chemical interaction between drug and polymers used. Precompression and postcompression parameters complied with pharmacopoeial limit for the tablets. In-vitro release studies was performed and the results indicates that matrix tablet  (F9) containing 50% w/w blend of natural and synthetic polymer has better controlled release for a period of 24 h

Design and evaluation of timolol maleate ocuserts

A remarkable attempt was made to prepare timolol maleate ocuserts, which is significant beta adreno receptor antagonist, by the aid of different of different ratio of composition of polymers such as EC, HPMC and Eudragit RS 100. Twelve batches of suitable ophthalmic films formulated by the method of solvent casting technique. Out of which the best formulation was found out the zero order release was observed in batch and was considered as the least drug releasing one. The formulated ocuserts were flexible, uniform and was meant for physic-chemical evaluator parameters, in vitro drug release profile and in vivo evaluation made on male rabbit

Research studies on polymeric effect of indomethacine transdermal films

The objective of this study was to design and evaluate transdermal patches of Indomethacine using HPMC, EC and Eudragit RLPO using solvent casting technique. The in vitro drug release studies were performed by using the USP (paddle type) dissolution list apparatus in 1000 ml of 0.1N HCl (Medium Employed) at 37o C room temperature for an rpm maintained at 100 within a stipulated time interval of 15 minutes. The withdrawn Samples were analyzed by using UV visible  spectrophotometer at 268 mm using regent blank. The prepared  transdermal patches had undergone physic chemical evaluator parameters such as PMA, PML, swelling index, water vapour transmission rate, film thickness, weight cheek, and folding Endurance and drug content clearance. In vitro dissolution study of drug along with different  combination of polymers; i.e. HPMC, EC and Eudragit has been  performed; out of which batch B6 shows the best moisture of films and the graph representing the best controlled drug release. As the percentage of ethyl cellulose was reduced the rate of the release of the drug was increased. [Batch B6 > HPMC: EC: Eudragit RLPO - 2:1:2]. Films with batch  code B6 shows better stability and suitability. Higuchi’s plot revealed that the predominant Mechanism of drug release was diffusio

Controlled drug delivery of diltiazem hydrochloride as transdermal patches: a novel approach on formulation evaluation in vitro and in vivo parameters

A significant effort was done to formulate transdermal patches (Paranjothi 1998) of Diltiazem Hydrochloride (DH), a benzothiazepine calcium channel blocker, mainly meant for the treatment of hypertension, chronic stable angina pectoris; by using hydroxy ethyl cellulose, ethyl cellulose and Eudragit RLPO. Six batches of transdermal patches were prepared by solvent casting technique in which the best formulation was found out. The polymers HEC, EC and Eudragit RLPO were incorporated with Diltiazem Hydrochloride in various proportions, out of which the best formulation on the ratio [HEC: EC: EUDRAGIT RLPO-1:1:2] with the drug was determined. The prepared transdermal patches were spherical, uniform in shape and white in color. The obtained transdermal films were evaluated for physico-chemical characteristics, in vitro release profile and in vivo evaluation in albino mice. Higuchis plot studies revealed that the predominant mechanism of drug release was diffusion

Effect of polymeric activity on transdermal patches of Glipizide

An effort was made to formulate transdermal patches of Glipizide which is a potent antidiabetic drug by using different ratio of polymers like hydroxy propyl methyl cellulose, ethyl cellulose and Eudragit. Eight batches of transdermal patches were prepared by solvent casting technique in which the best formulation was found out. The polymers such as HPMC, Ethyl cellulose, Eudragit were incorporated with Glipizide in various proportions, out of which the best formulation on the ratio (HPMC: EC: Eudragit - 2:2:1) with the drug was determined. The prepared transdermal patches were uniform in shape and white in color which was calculated for physicochemical characteristics, invitro release profile, and in-vivo evaluation on mice. Higuchis plot studies revealed that the predominant mechanism of drug release was diffusion

Integrated mission for sustainable development : Chiknayakanhalli Taluk, Tumkur district, Karnataka State

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