Postabortion family planning operations research study in Perm, Russia

EngenderHealth, the Population Council’s FRONTIERS program, and the Research Center of Obstetrics, Gynecology, and Perinatology of the Russian Academy of Medical Sciences, with support from the Perm Health Departments, undertook an operations research study to test models for increasing contraceptive use and reducing the repeat abortion rate among abortion clients in Perm, Russia. The study also assessed the direct and indirect costs of abortion and contraceptive use incurred by women in the year following their index abortion (the abortion which took place the day of entry into the study). The findings of the study were significant for the training interventions and dissemination of educational materials and job aids. Results of the study indicate that institutionalizing family planning counseling for all abortion clients is a low-cost quality-enhancing intervention for the existing healthcare system that does not require increased personnel, purchase of expensive equipment, or remodeling of healthcare facilities. Because of this, the counseling interventions included in the study can be easily replicated in any Russian oblast or city healthcare facility

Assessing the feasibility, acceptability and cost of introducing postabortion care in health centres and dispensaries in rural Tanzania

The EngenderHealth ACQUIRE Project has been supporting the Tanzanian Ministry of Health (MOH) since early 2005 to decentralize the management of postabortion care (PAC) services to primary healthcare facilities (health centers and dispensaries), with the intention of bringing services closer to women who are unable to access them at district hospitals. Findings from this study were provided to the MOH and ACQUIRE to address issues arising from introduction of the intervention; and in September 2006, to assess the feasibility, cost, and effectiveness of the intervention. Findings show that the intervention appears to have broadened service providers’ range of clinical skills and led to an increase in the number of women accessing family planning services after the evacuation. Facilities are well prepared to provide the PAC services, and few clients were being referred for advanced clinical management for incomplete abortions within 12 weeks of conception. The report concludes that decentralizing PAC services to health centers and dispensaries is feasible and effective, and the approach could be scaled up at a reasonable cost to other lower level facilities in Tanzania

"London is avocado on toast” : the urban imaginaries of the #LondonIsOpen campaign

This article examines the production, representations, and reactions to the #LondonIsOpen campaign to ask how urban imaginaries are produced and what they entail for understanding the city. The analysis considers how the idea of a cosmopolitan, diverse, and multicultural city is framed, what it includes and excludes, and the distinct geographies of the city it produces. It draws on three data sources: documentary analysis of videos used in the campaign; social media analysis of tweets using #LondonIsOpen; and semi-structured interviews with key figures in the campaign team. The main arguments are that the appeal to openness contributes to the versatility of the campaign and the range of responses to it, making it highly adaptable and flexible to respond to current affairs; and that open London is geographically selective and imagined as business focused; trendy; and cosmopolitan. In turn, the reactions to the idea of open London range from seeking a borderless world to anti-migrant rhetoric. Although the campaign represents London as welcoming and inclusive, such welcoming is partial and subject to contestation. The article concludes that over time, the openness of #LondonIsOpen has come to serve multiple political functions and act as a brand for the city

K+ Total Cross-Sections on C-12 and Medium Effects in Nuclei

Journals published by the American Physical Society can be found at http://publish.aps.org/The total cross sections for K+ mesons on carbon and deuterium nuclei have been measured at eleven momenta in the range 450-740 MeV/c. The experimental technique was of the standard transmission type. The K+ meson is the least strongly interacting of available hadronic probes, with a long mean free path in nuclear matter. At low incident momentum the K+ N interaction is dominated by the S11 phase shift and varies slowly with energy. These characteristics make the K+ an ideal tool for probing the nuclear volume to reveal nuclear medium effects. Measurements of the ratio of the total cross sections, per nucleon, of K+-C-12 to K+-d have been suggested as a way to reveal effects of the nuclear medium. The total cross section ratios are found to lie significantly above those predicted by the usual nuclear medium corrections. This suggests that novel phenomena axe taking place within the nucleus. Several models which incorporate such phenomena are discussed, including nucleon "swelling," mass rescaling, nuclear pions, and relativistic effects

Genetic Identification of a Network of Factors that Functionally Interact with the Nucleosome Remodeling ATPase ISWI

Nucleosome remodeling and covalent modifications of histones play fundamental roles in chromatin structure and function. However, much remains to be learned about how the action of ATP-dependent chromatin remodeling factors and histone-modifying enzymes is coordinated to modulate chromatin organization and transcription. The evolutionarily conserved ATP-dependent chromatin-remodeling factor ISWI plays essential roles in chromosome organization, DNA replication, and transcription regulation. To gain insight into regulation and mechanism of action of ISWI, we conducted an unbiased genetic screen to identify factors with which it interacts in vivo. We found that ISWI interacts with a network of factors that escaped detection in previous biochemical analyses, including the Sin3A gene. The Sin3A protein and the histone deacetylase Rpd3 are part of a conserved histone deacetylase complex involved in transcriptional repression. ISWI and the Sin3A/Rpd3 complex co-localize at specific chromosome domains. Loss of ISWI activity causes a reduction in the binding of the Sin3A/Rpd3 complex to chromatin. Biochemical analysis showed that the ISWI physically interacts with the histone deacetylase activity of the Sin3A/Rpd3 complex. Consistent with these findings, the acetylation of histone H4 is altered when ISWI activity is perturbed in vivo. These findings suggest that ISWI associates with the Sin3A/Rpd3 complex to support its function in vivo

Reperfusion injury following cerebral ischemia: pathophysiology, MR imaging, and potential therapies

INTRODUCTION: Restoration of blood flow following ischemic stroke can be achieved by means of thrombolysis or mechanical recanalization. However, for some patients, reperfusion may exacerbate the injury initially caused by ischemia, producing a so-called “cerebral reperfusion injury”. Multiple pathological processes are involved in this injury, including leukocyte infiltration, platelet and complement activation, postischemic hyperperfusion, and breakdown of the blood–brain barrier. METHODS/RESULTS AND CONCLUSIONS: Magnetic resonance imaging (MRI) can provide extensive information on this process of injury, and may have a role in the future in stratifying patients’ risk for reperfusion injury following recanalization. Moreover, different MRI modalities can be used to investigate the various mechanisms of reperfusion injury. Antileukocyte antibodies, brain cooling and conditioned blood reperfusion are potential therapeutic strategies for lessening or eliminating reperfusion injury, and interventionalists may play a role in the future in using some of these therapies in combination with thrombolysis or embolectomy. The present review summarizes the mechanisms of reperfusion injury and focuses on the way each of those mechanisms can be evaluated by different MRI modalities. The potential therapeutic strategies are also discussed

Cultural geographies of extinction: animal culture amongst Scottish ospreys

This paper explores cultural geographies of extinction. I trace the decline of the Scottish osprey during the nineteenth century, and its enduring, haunting presence in the landscape today. Taking inspiration from the environmental humanities, extinction is framed as an event affecting losses that exceed comprehension in terms merely of biological species numbers and survival rates. Disavowing the ‘species thinking’ of contemporary conservation biopolitics, the osprey’s extinction story pays attention to the worth of ‘animal cultures’. Drawing a hybrid conceptual framework from research in the environmental humanities, ‘speculative’ ethology and more-than-human geographies, I champion an experimental attention to the cultural geographies of animals in terms of historically contingent, communally shared, spatial practices and attachments. In doing so, I propose nonhuman cultural geographies as assemblages that matter, and which are fundamentally at stake in the face of extinction