Optical Characterization of Benign and Malignant Breast Lesions by Perturbative Model

The characterization of benign and malignant breast lesions was performed by the use of a perturbative model. Concentrations of blood, lipid, water and collagen were obtained. Differences between lesions and healthy tissue were observed

First in-vivo diffuse optics application of a time-domain multiwavelength wearable optode

The optode is an innovative, ultra-compact (few cm3) multiwavelength system for timedomain diffuse optics. We present here the first in-vivo measurements that benefit from this technological breakthrough

A multi-laboratory comparison of photon migration instruments and their performances – the BitMap Exercise

Performance assessment and standardization are indispensable for instruments of clinical relevance in general and clinical instrumentation based on photon migration/diffuse optics in particular. In this direction, a multi-laboratory exercise was initiated with the aim of assessing and comparing their performances. 29 diffuse optical instruments belonging to 11 partner institutions of a European level Marie Curie Consortium BitMap1 were considered for this exercise. The enrolled instruments covered different approaches (continuous wave, CW; frequency domain, FD; time domain, TD and spatial frequency domain imaging, SFDI) and applications (e.g. mammography, oximetry, functional imaging, tissue spectroscopy). 10 different tests from 3 well-accepted protocols, namely, the MEDPHOT2, the BIP3, and the nEUROPt4 protocols were chosen for the exercise and the necessary phantoms kits were circulated across labs and institutions enrolled in the study. A brief outline of the methodology of the exercise is presented here. Mainly, the design of some of the synthetic descriptors, (single numeric values used to summarize the result of a test and facilitate comparison between instruments) for some of the tests will be discussed.. Future actions of the exercise aim at deploying these measurements onto an open data repository and investigating common analysis tools for the whole dataset

Multi-laboratory efforts for the standardization of performance assessment of diffuse optics instruments - The BitMap Exercise

A multi-laboratory exercise, involving 29 diffuse optical instruments, aimed at performance assessment of diffuse optics instruments on standardized protocols is presented. The overarching methodology and future actions will also be discussed

In vivo optical biopsy of the calcaneous: a novel diagnostic tool for osteoporosis?

In vivo optical biopsy of the calcaneous: a novel diagnostic tool for osteoporosis

In vivo multi-distance multi-wavelength time-resolved reflectance spectroscopy of layered tissues

In this work time-resolved reflectance spectroscopy (TRS) measurements were performed in vivo on biological tissues (arm and forehead) over a broad spectral range (610- 1000 nm) and at different interfiber distances (2-4 cm), by a fully automated system based on mode-locked, continuously tunable laser sources and on time-correlated single photon counting for detection. Preliminary estimates of average tissue optical properties are obtained by interpreting the TRS curves at each wavelength with a homogeneous model for photon migration. The scattering coefficient decreases progressively upon increasing wavelength, while the absorption line shapes show the typical spectral features of the principal tissue components (hemoglobin, water, and lipids), with different weight depending on the tissue type and structure. The best fit of the absorption spectra with the spectra of the pure constituents and of the reduced scattering spectra to Mie theory provided information on the average percentage composition of the different tissues and on the average equivalent tissue structure, respectively. Moreover, TRS measurements at different interfiber distances allowed us to probe different tissue depths, showing the presence of a inhomogeneous structure with different average optical properties