The wider benefits of education and training : a comparative longitudinal study

"This report presents findings from a comparative longitudinal study of the changing relationship between education, training and various measures of employability and well-being. The aim of this study was to explore the extent to which education and/or work-related training confer employmentrelated benefits over and above the now well-established positive effects these have on earnings and employment. In so doing, it examines the concept of ‘employability’ and considers how this might be extended to incorporate some notion of well-being. The study investigates the links between education, training, employment, earnings and well-being and reveals the changing situation experienced by young adults over the past decade" -- page 1

A fussy revisitation of antiprotons as a tool for Dark Matter searches

Antiprotons are regarded as a powerful probe for Dark Matter (DM) indirect detection and indeed current data from PAMELA have been shown to lead to stringent constraints. However, in order to exploit their constraining/discovery power properly and especially in anticipation of the exquisite accuracy of upcoming data from AMS, great attention must be put into effects (linked to their propagation in the Galaxy) which may be perceived as subleasing but actually prove to be quite relevant. We revisit the computation of the astrophysical background and of the DM antiproton fluxes fully including the effects of: diffusive reacceleration, energy losses including tertiary component and solar modulation (in a force field approximation). We show that their inclusion can somewhat modify the current bounds, even at large DM masses, and that a wrong interpretation of the data may arise if they are not taken into account. The numerical results for the astrophysical background are provided in terms of fit functions; the results for Dark Matter are incorporated in the new release of the PPPC4DMID.Comment: v3: small comments and references added, matches journal versio

The economic and social consequences of unemployment and long-term unemployment

This thesis studies the economic and social consequences of unemployment and long-term (or repeated) unemployment. The first two chapters are concerned with economic consequences. They study how unemployment affects the working of the labour market. The last two chapters are interested in social consequences. They look at whether future generations' outcomes are altered by their parents' unemployment. Chapter two uses data on UK regions over a period of 23 years to test the hypothesis that the composition of unemployment alters the dampening effect of unemployment on wages. Several specifications are estimated using dynamic panel data methods and are tested to check the robustness of the results. The hypothesis is verified for manual or unskilled workers, but not for non-manual or skilled workers. The next three chapters use the British National Child Development Study (NCDS). The third chapter studies the job search behaviour of individuals who declared themselves unemployed and looking for work when aged 23 years old. We define job search as the combination of three decisions: whether they have considered applying for a job which would mean moving house, which would have a lower pay than their previous job, or which would require a lower qualification. We find that using a model that incorporates the dependence of these decisions improves efficiency. Young people who have been unemployed before are found to accept mobility but not to alter their expectations on wages and skill content. In the fourth chapter, we want to determine whether the labour market situation of the parents influences in any way the social behaviour of children. The findings show that, controlling for - persistent - financial difficulties, the unemployment of the father during childhood seems to have a detrimental effect on his children's outcomes. There is some evidence that those who have a non-working mother during early childhood are better off than others, except in cases where the mother is single. The last chapter draws on the previous one and studies whether these effects can be translated into unfavourable outcomes in adult life, in particular social exclusion. A new index of social exclusion is constructed. We find that anti-social behaviour and social difficulties during childhood are associated with later risks of social exclusion

AMS-02 antiprotons, at last! Secondary astrophysical component and immediate implications for Dark Matter

Using the updated proton and helium fluxes just released by the AMS-02 experiment we reevaluate the secondary astrophysical antiproton to proton ratio and its uncertainties, and compare it with the ratio preliminarly reported by AMS-02. We find no unambiguous evidence for a significant excess with respect to expectations. Yet, some preference for a flatter energy dependence of the diffusion coefficient starts to emerge. Also, we provide a first assessment of the room left for exotic components such as Galactic Dark Matter annihilation or decay, deriving new stringent constraints.Comment: 12 pages, 5 figures; Comments and clarifications added (including an appendix), matches version published on JCA

Eye eccentricity modifies the perception of whole-body rotation

International audienceIn order to explore the effect of gaze orientation on whole-body rotation perception, ten healthy participants were rotated in the dark while fixating on a visual target located either straight ahead or 15 degrees to the right. A vestibular-memory contingent saccade paradigm was used to estimate the rotation perception. The results attest to the participants' ability to accurately perceive their rotation, based solely on the intrinsic inputs (somesthetic and mainly vestibular), since the correlation between the imposed body rotation and the saccade amplitude was significant and positive. However, the rotation perception was less accurate and of lesser magnitude when the gaze was deviated in the opposite direction to the rotation than when it was either straight ahead or deviated in the direction of the rotation. This can be interpreted as the perceptual equivalent of Alexander's law

New Marker of Colon Cancer Risk Associated with Heme Intake: 1,4-Dihydroxynonane Mercapturic Acid

Background: Red meat consumption is associated with an increased risk of colon cancer. Animal studies show that heme, found in red meat, promotes preneoplastic lesions in the colon, probably due to the oxidative properties of this compound. End products of lipid peroxidation, such as 4-hydroxynonenal metabolites or 8-iso-prostaglandin-F2 (8-iso-PGF2), could reflect this oxidative process and could be used as biomarkers of colon cancer risk associated with heme intake. Methods: We measured urinary excretion of 8-iso-PGF2 and 1,4-dihydroxynonane mercapturic acid (DHN-MA), the major urinary metabolite of 4-hydroxynonenal, in three studies. In a short-term and a carcinogenesis long-term animal study, we fed rats four different diets (control, chicken, beef, and blood sausage as a high heme diet). In a randomized crossover human study, four different diets were fed (a 60 g/d red meat baseline diet, 120 g/d red meat, baseline diet supplemented with heme iron, and baseline diet supplemented with non-heme iron). Results: DHN-MA excretion increased dramatically in rats fed high heme diets, and the excretion paralleled the number of preneoplastic lesions in azoxymethane initiated rats (P < 0.0001). In the human study, the heme supplemented diet resulted in a 2-fold increase in DHN-MA (P < 0.001). Urinary 8-iso-PGF2 increased moderately in rats fed a high heme diet (P < 0.0001), but not in humans. Conclusion: Urinary DHN-MA is a useful noninvasive biomarker for determining the risk of preneoplastic lesions associated with heme iron consumption and should be further investigated as a potential biomarker of colon cancer risk. (Cancer Epidemiol Biomarkers Prev 2006;15(11):2274–9

MiCoViTo: a tool for gene-centric comparison and visualization of yeast transcriptome states

BACKGROUND: Information obtained by DNA microarray technology gives a rough snapshot of the transcriptome state, i.e., the expression level of all the genes expressed in a cell population at any given time. One of the challenging questions raised by the tremendous amount of microarray data is to identify groups of co-regulated genes and to understand their role in cell functions. RESULTS: MiCoViTo (Microarray Comparison Visualization Tool) is a set of biologists' tools for exploring, comparing and visualizing changes in the yeast transcriptome by a gene-centric approach. A relational database includes data linked to genome expression and graphical output makes it easy to visualize clusters of co-expressed genes in the context of available biological information. To this aim, upload of personal data is possible and microarray data from fifty publications dedicated to S. cerevisiae are provided on-line. A web interface guides the biologist during the usage of this tool and is freely accessible at . CONCLUSIONS: MiCoViTo offers an easy-to-read picture of local transcriptional changes connected to current biological knowledge. This should help biologists to mine yeast microarray data and better understand the underlying biology. We plan to add functional annotations from other organisms. That would allow inter-species comparison of transcriptomes via orthology tables

Characterization of a novel type of HIV-1 particle assembly inhibitor using a quantitative Luciferase-Vpr packaging-based assay

The HIV-1 auxiliary protein Vpr and Vpr-fusion proteins can be copackaged with Gag precursor (Pr55Gag) into virions or membrane-enveloped virus-like particles (VLP). Taking advantage of this property, we developed a simple and sensitive method to evaluate potential inhibitors of HIV-1 assembly in a living cell system. Two proteins were coexpressed in recombinant baculovirus-infected Sf9 cells, Pr55Gag, which formed the VLP backbone, and luciferase fused to the N-terminus of Vpr (LucVpr). VLP-encapsidated LucVpr retained the enzymatic activity of free luciferase. The levels of luciferase activity present in the pelletable fraction recovered from the culture medium correlated with the amounts of extracellular VLP released by Sf9 cells assayed by conventional immunological methods. Our luciferase-based assay was then applied to the characterization of betulinic acid (BA) derivatives that differed from the leader compound PA-457 (or DSB) by their substituant on carbon-28. The beta-alanine-conjugated and lysine-conjugated DSB could not be evaluated for their antiviral potentials due to their high cytotoxicity, whereas two other compounds with a lesser cytotoxicity, glycine-conjugated and ε-NH-Boc-lysine-conjugated DSB, exerted a dose-dependent negative effect on VLP assembly and budding. A fifth compound with a low cytotoxicity, EP-39 (ethylene diamine-conjugated DSB), showed a novel type of antiviral effect. EP-39 provoked an aberrant assembly of VLP, resulting in nonenveloped, morula-like particles of 100-nm in diameter. Each morula was composed of nanoparticle subunits of 20-nm in diameter, which possibly mimicked transient intermediates of the HIV-1 Gag assembly process. Chemical cross-linking in situ suggested that EP-39 favored the formation or/and persistence of Pr55Gag trimers over other oligomeric species. EP-39 showed a novel type of negative effect on HIV-1 assembly, targeting the Pr55Gag oligomerisation. The biological effect of EP-39 underlined the critical role of the nature of the side chain at position 28 of BA derivatives in their anti-HIV-1 activity