JWSTJWST Insight Into a Lensed HSTHST-dark Galaxy and its Quiescent Companion at z=2.58z=2.58

Using the novel $JWST$/NIRCam observations in the Abell 2744 field, we present a first spatially resolved overview of an $HST$-dark galaxy, spectroscopically confirmed at $z=2.58$ with magnification $\mu\approx1.9$. While being largely invisible at $\sim$1 $\mu$m with NIRCam, except for sparse clumpy sub-structures, the object is well-detected and resolved in the long-wavelength bands with a spiral shape clearly visible in F277W. By combining ancillary ALMA and $Herschel$ data, we infer that this object is an edge-on dusty spiral with an intrinsic stellar mass log$(M_*/M_\odot)\sim11.3$ and a dust-obscured SFR$\sim 300~M_\odot$~yr$^{-1}$. A massive quiescent galaxy (log$(M_*/M_\odot)\sim10.8$) with tidal features lies 2\farcs{0} away ($r$$\sim$9 kpc), at a consistent redshift as inferred by $JWST$ photometry, indicating a potential major merger. The dusty spiral lies on the main-sequence of star formation, and shows high dust attenuation in the optical ($3<A_{\rm V}<4.5$). In the far-infrared, its integrated dust SED is optically thick up to $\lambda_0 \sim 500$ $\mu$m, further supporting the extremely dusty nature. Spatially resolved analysis of the $HST$-dark galaxy reveals a largely uniform $A_{\rm V}\sim 4$ area spanning $\sim$57 kpc$^2$, which spatially matches to the ALMA 1 mm continuum emission. Accounting for the surface brightness dimming and the depths of current $JWST$ surveys, unlensed analogs of the $HST$-dark galaxy at $z>4$ would be only detectable in F356W and F444W in UNCOVER-like survey, and become totally $JWST$-dark at $z\sim6$. This suggests that detecting highly attenuated galaxies in the Epoch of Reionization might be a challenging task for $JWST$.Comment: 15 pages, 5 figures, 1 table. Accepted to ApJ

Recommendations for Implementing Lung Cancer Screening with Low-Dose Computed Tomography in Europe.

Lung cancer screening (LCS) with low-dose computed tomography (LDCT) was demonstrated in the National Lung Screening Trial (NLST) to reduce mortality from the disease. European mortality data has recently become available from the Nelson randomised controlled trial, which confirmed lung cancer mortality reductions by 26% in men and 39-61% in women. Recent studies in Europe and the USA also showed positive results in screening workers exposed to asbestos. All European experts attending the "Initiative for European Lung Screening (IELS)"-a large international group of physicians and other experts concerned with lung cancer-agreed that LDCT-LCS should be implemented in Europe. However, the economic impact of LDCT-LCS and guidelines for its effective and safe implementation still need to be formulated. To this purpose, the IELS was asked to prepare recommendations to implement LCS and examine outstanding issues. A subgroup carried out a comprehensive literature review on LDCT-LCS and presented findings at a meeting held in Milan in November 2018. The present recommendations reflect that consensus was reached

Incidence and outcome of invasive candidiasis in intensive care units (ICUs) in Europe: results of the EUCANDICU project

BACKGROUND: The objective of this study was to assess the cumulative incidence of invasive candidiasis (IC) in intensive care units (ICUs) in Europe. METHODS: A multinational, multicenter, retrospective study was conducted in 23 ICUs in 9 European countries, representing the first phase of the candidemia/intra-abdominal candidiasis in European ICU project (EUCANDICU). RESULTS: During the study period, 570 episodes of ICU-acquired IC were observed, with a cumulative incidence of 7.07 episodes per 1000 ICU admissions, with important between-center variability. Separated, non-mutually exclusive cumulative incidences of candidemia and IAC were 5.52 and 1.84 episodes per 1000 ICU admissions, respectively. Crude 30-day mortality was 42%. Age (odds ratio [OR] 1.04 per year, 95% CI 1.02-1.06, p&nbsp;&lt; 0.001), severe hepatic failure (OR 3.25, 95% 1.31-8.08, p 0.011), SOFA score at the onset of IC (OR 1.11 per point, 95% CI 1.04-1.17, p 0.001), and septic shock (OR 2.12, 95% CI 1.24-3.63, p 0.006) were associated with increased 30-day mortality in a secondary, exploratory analysis. CONCLUSIONS: The cumulative incidence of IC in 23 European ICUs was 7.07 episodes per 1000 ICU admissions. Future in-depth analyses will allow explaining part of the observed between-center variability, with the ultimate aim of helping to improve local infection control and antifungal stewardship projects and interventions

Recommendations for implementing lung cancer screening with low-dose computed tomography in Europe

Lung cancer screening (LCS) with low-dose computed tomography (LDCT) was demonstrated in the National Lung Screening Trial (NLST) to reduce mortality from the disease. European mortality data has recently become available from the Nelson randomised controlled trial, which confirmed lung cancer mortality reductions by 26% in men and 39–61% in women. Recent studies in Europe and the USA also showed positive results in screening workers exposed to asbestos. All European experts attending the “Initiative for European Lung Screening (IELS)”—a large international group of physicians and other experts concerned with lung cancer—agreed that LDCT-LCS should be implemented in Europe. However, the economic impact of LDCT-LCS and guidelines for its effective and safe implementation still need to be formulated. To this purpose, the IELS was asked to prepare recommendations to implement LCS and examine outstanding issues. A subgroup carried out a comprehensive literature review on LDCT-LCS and presented findings at a meeting held in Milan in November 2018. The present recommendations reflect that consensus was reached

Practice patterns and 90-day treatment-related morbidity in early-stage cervical cancer

To evaluate the impact of the Laparoscopic Approach to Cervical Cancer (LACC) Trial on patterns of care and surgery-related morbidity in early-stage cervical cancer

Characteristics and patterns of care of endometrial cancer before and during COVID-19 pandemic

Objective: Coronavirus disease 2019 (COVID-19) outbreak has correlated with the disruption of screening activities and diagnostic assessments. Endometrial cancer (EC) is one of the most common gynecological malignancies and it is often detected at an early stage, because it frequently produces symptoms. Here, we aim to investigate the impact of COVID-19 outbreak on patterns of presentation and treatment of EC patients. Methods: This is a retrospective study involving 54 centers in Italy. We evaluated patterns of presentation and treatment of EC patients before (period 1: March 1, 2019 to February 29, 2020) and during (period 2: April 1, 2020 to March 31, 2021) the COVID-19 outbreak. Results: Medical records of 5,164 EC patients have been retrieved: 2,718 and 2,446 women treated in period 1 and period 2, respectively. Surgery was the mainstay of treatment in both periods (p=0.356). Nodal assessment was omitted in 689 (27.3%) and 484 (21.2%) patients treated in period 1 and 2, respectively (p&lt;0.001). While, the prevalence of patients undergoing sentinel node mapping (with or without backup lymphadenectomy) has increased during the COVID-19 pandemic (46.7% in period 1 vs. 52.8% in period 2; p&lt;0.001). Overall, 1,280 (50.4%) and 1,021 (44.7%) patients had no adjuvant therapy in period 1 and 2, respectively (p&lt;0.001). Adjuvant therapy use has increased during COVID-19 pandemic (p&lt;0.001). Conclusion: Our data suggest that the COVID-19 pandemic had a significant impact on the characteristics and patterns of care of EC patients. These findings highlight the need to implement healthcare services during the pandemic

POLITICHE CULTURALI E SVILUPPO LOCALE: TRA TEORIA E PRATICHE

The aim of this work study is to emphasize the need and urgency to for innovation in cultural governmental policies. Innovation is necessary because new technologies have fundamentally altered the production processes, giving giving new and more importance to intangible elements and thus necessitating enhanced policy innovation. Global competitiveness has increased for those activities which incorporate research and creativity. In this context, and from an economic point of view, the cultural and creative activities play an increasingly important role - both intrinsically, itself and for their impact on other industries. Indeed economic theory has begun to rethink the development processes and global competition, taking into account intangible factors. The policies, and in particular cultural ones, must therefore follow suit, because cultural and creative activities actively contribute defining the conditions in terms of human capital and creativity, for a «smart» and sustainable territorial development. Some drawn from practical experiences show that cultural policies, whichthat have actively supported the innovations of processes and products, have also had positive effects on local economies