161 research outputs found
A new viable region of the inert doublet model
The inert doublet model, a minimal extension of the Standard Model by a
second Higgs doublet, is one of the simplest and most attractive scenarios that
can explain the dark matter. In this paper, we demonstrate the existence of a
new viable region of the inert doublet model featuring dark matter masses
between Mw and about 160 GeV. Along this previously overlooked region of the
parameter space, the correct relic density is obtained thanks to cancellations
between different diagrams contributing to dark matter annihilation into gauge
bosons (W+W- and ZZ). First, we explain how these cancellations come about and
show several examples illustrating the effect of the parameters of the model on
the cancellations themselves and on the predicted relic density. Then, we
perform a full scan of the new viable region and analyze it in detail by
projecting it onto several two-dimensional planes. Finally, the prospects for
the direct and the indirect detection of inert Higgs dark matter within this
new viable region are studied. We find that present direct detection bounds
already rule out a fraction of the new parameter space and that future direct
detection experiments, such as Xenon100, will easily probe the remaining part
in its entirety.Comment: 27 pages, 16 figure
Temperature-dependent NMR features of the Al65Cu20Ru15 icosahedral alloy
The Al65Cu20Ru15 icosahedral alloy was studied by Al27 nuclear magnetic resonance from 150 to 1110 K. The Knight shift of the unresolved resonance line was observed to significantly increase above 500 K. This uncommon temperature dependence of the Knight shift is interpreted in terms of the presence of a pseudogap at the Fermi level. The spin-lattice relaxation rate deviates from the linear temperature dependence of Korringa relaxation below 500 K, and above 500 K it is dominated by a thermally activated process with a small activation energy of 0.48 eV. This energy is distinctly different from the activation energy observed in simple metallic alloys
250Program overview: Diseases treated, types of transplants, regimens and outcome in an outpatient blood and marrow transplant program
The cosmic ray positron excess and neutralino dark matter
Using a new instrument, the HEAT collaboration has confirmed the excess of
cosmic ray positrons that they first detected in 1994. We explore the
possibility that this excess is due to the annihilation of neutralino dark
matter in the galactic halo. We confirm that neutralino annihilation can
produce enough positrons to make up the measured excess only if there is an
additional enhancement to the signal. We quantify the `boost factor' that is
required in the signal for various models in the Minimal Supersymmetric
Standard Model parameter space, and study the dependence on various parameters.
We find models with a boost factor greater than 30. Such an enhancement in the
signal could arise if we live in a clumpy halo. We discuss what part of
supersymmetric parameter space is favored (in that it gives the largest
positron signal), and the consequences for other direct and indirect searches
of supersymmetric dark matter.Comment: 11 pages, 6 figures, matches published version (PRD
The Nursing Worklife Model: Extending and Refining a New Theory
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75205/1/j.1365-2834.2007.00670.x.pd
Neutralino Dark Matter from MSSM Flat Directions in light of WMAP Result
The minimal supersymmetric standard model (MSSM) has a truly supersymmetric
way to explain both the baryon asymmetry and cold dark matter in the present
Universe, that is, ``Affleck-Dine baryo/DM-genesis.'' The associated late-time
decay of Q-balls directly connects the origins of the baryon asymmetry and dark
matter, and also predicts a specific nature of the LSP. In this paper, we
investigate the prospects for indirect detection of these dark matter
candidates observing high energy neutrino flux from the Sun, and hard positron
flux from the halo. We also update the previous analysis of the direct
detection in hep-ph/0205044 by implementing the recent result from WMAP
satellite.Comment: 32 pages, including 40 figure
Bottom-Tau Unification in SUSY SU(5) GUT and Constraints from b to s gamma and Muon g-2
An analysis is made on bottom-tau Yukawa unification in supersymmetric (SUSY)
SU(5) grand unified theory (GUT) in the framework of minimal supergravity, in
which the parameter space is restricted by some experimental constraints
including Br(b to s gamma) and muon g-2. The bottom-tau unification can be
accommodated to the measured branching ratio Br(b to s gamma) if superparticle
masses are relatively heavy and higgsino mass parameter \mu is negative. On the
other hand, if we take the latest muon g-2 data to require positive SUSY
contributions, then wrong-sign threshold corrections at SUSY scale upset the
Yukawa unification with more than 20 percent discrepancy. It has to be
compensated by superheavy threshold corrections around the GUT scale, which
constrains models of flavor in SUSY GUT. A pattern of the superparticle masses
preferred by the three requirements is also commented.Comment: 21pages, 6figure
Supersymmetric Dark Matter and Yukawa Unification
An analysis of supersymmetric dark matter under the Yukawa unification
constraint is given. The analysis utilizes the recently discovered region of
the parameter space of models with gaugino mass nonuniversalities where large
negative supersymmetric corrections to the b quark mass appear to allow
unification for a positive sign consistent with the and constraints. In the present analysis we use the
revised theoretical determination of ()
in computing the difference which takes account of
a reevaluation of the light by light contribution which has a positive sign.
The analysis shows that the region of the parameter space with
nonuniversalities of the gaugino masses which allows for unification of Yukawa
couplings also contains regions which allow satisfaction of the relic density
constraint. Specifically we find that the lightest neutralino mass consistent
with the relic density constraint, unification for SU(5) and
unification for SO(10) in addition to other constraints lies in the region
below 80 GeV. An analysis of the maximum and the minimum neutralino-proton
scalar cross section for the allowed parameter space including the effect of a
new determination of the pion-nucleon sigma term is also given. It is found
that the full parameter space for this class of models can be explored in the
next generation of proposed dark matter detectors.Comment: 28 pages,nLatex including 5 fig
Broad-spectrum in vitro activity of macrophage infectivity potentiator inhibitors against Gram-negative bacteria and Leishmania major
Background
The macrophage infectivity potentiator (Mip) protein, which belongs to the immunophilin superfamily, is a peptidyl-prolyl cis/trans isomerase (PPIase) enzyme. Mip has been shown to be important for virulence in a wide range of pathogenic microorganisms. It has previously been demonstrated that small-molecule compounds designed to target Mip from the Gram-negative bacterium Burkholderia pseudomallei bind at the site of enzymatic activity of the protein, inhibiting the in vitro activity of Mip.
Objectives
In this study, co-crystallography experiments with recombinant B. pseudomallei Mip (BpMip) protein and Mip inhibitors, biochemical analysis and computational modelling were used to predict the efficacy of lead compounds for broad-spectrum activity against other pathogens.
Methods
Binding activity of three lead compounds targeting BpMip was verified using surface plasmon resonance spectroscopy. The determination of crystal structures of BpMip in complex with these compounds, together with molecular modelling and in vitro assays, was used to determine whether the compounds have broad-spectrum antimicrobial activity against pathogens.
Results
Of the three lead small-molecule compounds, two were effective in inhibiting the PPIase activity of Mip proteins from Neisseria meningitidis, Klebsiella pneumoniae and Leishmania major. The compounds also reduced the intracellular burden of these pathogens using in vitro cell infection assays.
Conclusions
These results indicate that Mip is a novel antivirulence target that can be inhibited using small-molecule compounds that prove to be promising broad-spectrum drug candidates in vitro. Further optimization of compounds is required for in vivo evaluation and future clinical applications
Reduced basis approximation and a posteriori error estimation for the time-dependent viscous Burgers’ equation
In this paper we present rigorous a posteriori L 2 error bounds for reduced basis approximations of the unsteady viscous Burgers’ equation in one space dimension. The a posteriori error estimator, derived from standard analysis of the error-residual equation, comprises two key ingredients—both of which admit efficient Offline-Online treatment: the first is a sum over timesteps of the square of the dual norm of the residual; the second is an accurate upper bound (computed by the Successive Constraint Method) for the exponential-in-time stability factor. These error bounds serve both Offline for construction of the reduced basis space by a new POD-Greedy procedure and Online for verification of fidelity. The a posteriori error bounds are practicable for final times (measured in convective units) T≈O(1) and Reynolds numbers ν[superscript −1]≫1; we present numerical results for a (stationary) steepening front for T=2 and 1≤ν[superscript −1]≤200.United States. Air Force Office of Scientific Research (AFOSR Grant FA9550-05-1-0114)United States. Air Force Office of Scientific Research (AFOSR Grant FA-9550-07-1-0425)Singapore-MIT Alliance for Research and Technolog
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